Impaired muscle Ca2+ and K+ regulation contribute to poor exercise performance post-lung transplantation

Lung transplant recipients (LTx) exhibit marked peripheral limitations to exercise. We investigated whether skeletal muscle Ca2+ and K+ regulation might be abnormal in eight LTx and eight healthy controls. Peak oxygen consumption and arterialized venous plasma [K+] (where brackets denote concentration) were measured during incremental exercise. Vastus lateralis muscle was biopsied at rest and analyzed for sarcoplasmic reticulum Ca2+ release, Ca2+ uptake, and Ca2+-ATPase activity rates; fiber composition; Na+-K+-ATPase (K+-stimulated 3-O-methylfluorescein phosphatase) activity and content ([3H]ouabain binding sites); as well as for [H+] and H+-buffering capacity. Peak oxygen consumption was 47% less in LTx (P < 0.05). LTx had lower Ca2+ release (34%), Ca2+ uptake (31%), and Ca2+-ATPase activity (25%) than controls (P < 0.05), despite their higher type II fiber proportion (LTx, 75.0 ± 5.8%; controls, 43.5 ± 2.1%). Muscle [H+] was elevated in LTx (P < 0.01), but buffering capacity was similar to controls. Muscle 3-O-methylfluorescein phosphatase activity was 31% higher in LTx (P < 0.05), but [3H]ouabain binding content did not differ significantly. However, during exercise, the rise in plasma [K+]-to-work ratio was 2.6-fold greater in LTx (P < 0.05), indicating impaired K+ regulation. Thus grossly subnormal muscle calcium regulation, with impaired potassium regulation, may contribute to poor muscular performance in LTx.

Poor governance sickens the Arts : we have the cure, Kenneth Myer Lecture for the George Fairfax Fellowship

We need to know more about governance in cultural nonprofit organisations (NPOs). Can good governance prevent financial crises in arts organisations? A vast research project has helped find the answers. Lack of artistic success is not the main cause of financial distress. NPOs in financial distress often have weak governing processes. Their board members need to know more about the problems leading to the crisis. We propose a governance framework to better monitor NPOs’ external and internal environments. Then we present the reactions to this governance framework from interviews with NPO managers. Finally, we report results from arts organisation consultancy and reconcile these findings with the ones collected through interviews.

Lift aim on poor targets, universities told

Commonwealth government participation targets for students from poor backgrounds should be extended beyond undergraduates to include postgraduate and research students, according to a visiting participation expert from Britain.

Land of the rare go for the poor who dream of university

A wicked problem is what policymakers call a messy social issue with multiple causes and answers that have little hope of pleasing everyone.

Unis slow to open doors to the poor

The Group of Eight research universities are tough institutions for disadvantaged students to get into, but they are not, according to a surprising new study, the toughest of the lot: that dubious honour goes to the University of Canberra.