16 resultados para OXIDATIVE DNA-DAMAGE
Filtro por publicador
- Aberdeen University (1)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (2)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (9)
- Aquatic Commons (4)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (24)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (6)
- Aston University Research Archive (16)
- Biblioteca Digital | Sistema Integrado de Documentación | UNCuyo - UNCUYO. UNIVERSIDAD NACIONAL DE CUYO. (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (30)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (20)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (5)
- Bioline International (2)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (22)
- Brock University, Canada (1)
- Bucknell University Digital Commons - Pensilvania - USA (2)
- CaltechTHESIS (6)
- CentAUR: Central Archive University of Reading - UK (22)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (30)
- Cochin University of Science & Technology (CUSAT), India (1)
- Coffee Science - Universidade Federal de Lavras (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (5)
- Deakin Research Online - Australia (16)
- Digital Commons at Florida International University (6)
- DigitalCommons@The Texas Medical Center (29)
- Duke University (14)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (2)
- Glasgow Theses Service (1)
- Greenwich Academic Literature Archive - UK (4)
- Helda - Digital Repository of University of Helsinki (12)
- Indian Institute of Science - Bangalore - Índia (30)
- INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES (IPEN) - Repositório Digital da Produção Técnico Científica - BibliotecaTerezine Arantes Ferra (1)
- Instituto Nacional de Saúde de Portugal (3)
- Instituto Politécnico de Bragança (1)
- Instituto Politécnico do Porto, Portugal (1)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (1)
- National Center for Biotechnology Information - NCBI (87)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (3)
- Portal de Revistas Científicas Complutenses - Espanha (3)
- Publishing Network for Geoscientific & Environmental Data (2)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (167)
- Queensland University of Technology - ePrints Archive (73)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (2)
- Repositório Institucional da Universidade de Aveiro - Portugal (4)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (2)
- Repositório Institucional da Universidade Federal do Rio Grande - FURG (2)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (177)
- Research Open Access Repository of the University of East London. (1)
- SAPIENTIA - Universidade do Algarve - Portugal (2)
- Savoirs UdeS : plateforme de diffusion de la production intellectuelle de l’Université de Sherbrooke - Canada (2)
- School of Medicine, Washington University, United States (3)
- Universidad del Rosario, Colombia (5)
- Universidad Politécnica de Madrid (1)
- Universidade Federal do Rio Grande do Norte (UFRN) (10)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (4)
- Université de Montréal (1)
- Université de Montréal, Canada (40)
- Université Laval Mémoires et thèses électroniques (2)
- University of Queensland eSpace - Australia (9)
- University of Washington (1)
- Worcester Research and Publications - Worcester Research and Publications - UK (2)
Resumo:
Ageing is a complex biological process for which underlying biochemical changes are still largely unknown. We performed comparative profiling of the cellular proteome and metabolome to understand the molecular basis of ageing in Caspase-2-deficient (Casp2(-/-)) mice that are a model of premature ageing in the absence of overt disease. Age-related changes were determined in the liver and serum of young (6-9 week) and aged (18-24 month) wild-type and Casp2(-/-) mice. We identified perturbed metabolic pathways, decreased levels of ribosomal and respiratory complex proteins and altered mitochondrial function that contribute to premature ageing in the Casp2(-/-) mice. We show that the metabolic profile changes in the young Casp2(-/-) mice resemble those found in aged wild-type mice. Intriguingly, aged Casp2(-/-) mice were found to have reduced blood glucose and improved glucose tolerance. These results demonstrate an important role for caspase-2 in regulating proteome and metabolome remodelling during ageing.