Systemic apomorphine alters HPA axis responses to interleukin-1β adminstration but not sound stress

Apomorphine is a dopamine receptor agonist that was recently licensed for the treatment of erectile dysfunction. However, although sexual activity can be stressful, there has been little investigation into whether treatments for erectile dysfunction affect stress responses. We have examined whether a single dose of apomorphine, sufficient to produce penile erections (50 μg/kg, i.a.), can alter basal or stress-induced plasma ACTH levels, or activity of central pathways thought to control the hypothalamic-pituitary-adrenal axis in rats. An immune challenge (interleukin-1β, 1 μg/kg, i.a.) was used as a physical stressor while sound stress (100 dB white noise, 30 min) was used as a psychological stressor. Intravascular administration of apomorphine had no effect on basal ACTH levels but did substantially increase the number of Fos-positive amygdala and nucleus tractus solitarius catecholamine cells. Administration of apomorphine prior to immune challenge augmented the normal ACTH response to this stressor at 90 min and there was a corresponding increase in the number of Fos-positive paraventricular nucleus corticotropin-releasing factor cells, paraventricular nucleus oxytocin cells and nucleus tractus solitarius catecholamine cells. However, apomorphine treatment did not alter ACTH or Fos responses to sound stress. These data suggest that erection-inducing levels of apomorphine interfere with hypothalamic-pituitary-adrenal axis inhibitory feedback mechanisms in response to a physical stressor, but have no effect on the response to a psychological stressor. Consequently, it is likely that apomorphine acts on a hypothalamic-pituitary-adrenal axis control pathway that is unique to physical stressors. A candidate for this site of action is the nucleus tractus solitarius catecholamine cell population and, in particular, A2 noradrenergic neurons.

Affect computing in film through sound energy dynamics

We develop an algorithm for the detection and classification of affective sound events underscored by specific patterns of sound energy dynamics. We relate the portrayal of these events to proposed high level affect or emotional coloring of the events. In this paper, four possible characteristic sound energy events are identified that convey well established meanings through their dynamics to portray and deliver certain affect, sentiment related to the horror film genre. Our algorithm is developed with the ultimate aim of automatically structuring sections of films that contain distinct shades of emotion related to horror themes for nonlinear media access and navigation. An average of 82% of the energy events, obtained from the analysis of the audio tracks of sections of four sample films corresponded correctly to the proposed affect. While the discrimination between certain sound energy event types was low, the algorithm correctly detected 71% of the occurrences of the sound energy events within audio tracks of the films analyzed, and thus forms a useful basis for determining affective scenes characteristic of horror in movies.

Social identity and sound change : the case of Wo in Shanghainese

Research has shown that language change is driven on one hand by forces internal to language itself such as grammar-internal systematic pressure, and on the other hand by social motives such as social identity. Language contact presents new features, but why is it that some of them are incorporated as variation and evolving into language change, while others are not? This paper reports a study on a sound change in Shanghainese, a dialect of the Chinese language. Data were collected in natural contexts of conversation followed by a brief interview with informants to gain identity related information about them. It has found that previously negative perception of status attached to a new sound induced by language/dialect contact changed into a positive perception, and people started to identify positively with this new sound. Further, there were differences in various different age and gender groups in taking up the new sound. As a result, this sound has evolved from a nonnative alternative to a systematic variation and it is being established as a sound change. This study has thus further confirmed that social identity plays a pivotal role in driving language features into language variation and language change.

Beyond narrative: sound design as dramaturgy in contemporary performance

Autobiographical performance is often characterised by a linguistic approach to storytelling. This paper presents discoveries from a practice-led research inquiry into the mediated translation of narrative elements within the making of autobiographical performance Train Tracks and Rooftops. Specifically, it presents the way sonic texts emerged within the process of translating away from narrative form. The paper sets out the technical aspects of the process and critiques the shift in meaning that comes from an understanding of sound dramaturgy and sound as performance architecture. The experience of the maker/performers' relationship to their live and mediated voice is discussed.

A sibling romance: the sound of romance reimagined

 A Sibling Romance: The Sound of Romance Reimagined explores the interplay between lived perceptual and sensual experience and the visual representation of it in the romantic novel and asks what happens to and within a creative artifact if the hierarchy of the senses is reimagined.

Music in worship: making spiritual connections through sound

Music has played a significant role in religion and spiritual settings over the centuries and continues to be included throughout church history, forming an important aspect of worship, contributing to spiritual growth and wellbeing. This article situates itself within a wider study on Spirituality and Wellbeing: Music in the community. Drawing on narrative reflection, the authors discusstheir experiences across Melbourne (Australia) and Potchefstroom (South Africa) and include some interview data from church musicians from the wider study in Melbourne in relation to how church music contributes to spirituality and impacts on wellbeing. As church musicians they argue that music in church settings can offer parishioners the opportunity to experienceand express spirituality in their life through sound. They recognize and acknowledge that music through singing, playing, improvising and listening is an aspect of spiritual connection that is not confined to the institution of the church or to a religion but is concerned with the connection wefeel and sense in mysterious and unknown places and spacesThe findings of this study are limited as it only focuses on the experience of the authors, hence, generalizations to other musicians or church settings cannot be made. The authors argue that music in church settings can enliven andtransform worship through music in which spiritual connections can be fostered between God and man that positively engender wellbeing.

Interview in Melbourne with Meg Labrum, National Film and Sound Archive of Australia, Canberra, June 16, 2015

A conversation with Meg Labrum (National Film and Sound Archive, Canberra),arguing that women have a disproportionate impact upon the programming of silent film at festivals. It asks how she works and, specifically, how the change to digital has impacted archival outreach and access today in Australia.

Sound the alarm: health and safety risks associated with alarm response for salaried and retained metropolitan firefighters

Responding to an emergency alarm poses a significant risk to firefighters' health and safety, particularly to cardiovascular health, physical and psychological stress, and fatigue. These risks have been largely categorised for salaried firefighters working 'on station'. Less is known about the factors that contribute to these risks for the vast number of non-salaried personnel who serve in retained roles, often deploying from home. The present study investigated the alarm response procedure for Australian metropolitan fire fighters, identifying common and divergent sources of risk for salaried and retained staff. There were significant differences in procedure between the two workgroups and this resulted in differences in risk profile between groups. Sleep and fatigue, actual response to the alarm stimulus, work-life balance and trauma emerged as sources of risk experienced differently by salaried and retained firefighters. Key findings included reports of fatigue in both groups, but particularly in the case of retained firefighters who manage primary employment as well as their retained position. This also translated into a poor sense of work-life balance. Both groups reported light sleep, insufficient sleep or fragmented sleep as a result of alarm response. In the case of salaried firefighters, this was associated with being woken on station when other appliances are called. There were risks from physical and psychological responses to the alarm stimulus, and reports of sleep inertia when driving soon after waking. The findings of this study highlight the common and divergent risks for these workgroups, and could be used in the ongoing management of firefighters' health and safety.