Dialogue with Hans-Georg Gadamer : the contribution of hermeneutics to understanding what a person is saying

This thesis reviews the development of philosophy of interpretation since the nineteenth century exemplified in the work of Hans-Georg Gadamer, It recognizes Gadamer as the foremost philosopher of hermeneutics in the twentieth century, who draws together the contributions of his predecessors into a major new development. The theme upon which this thesis engages in dialogue with Gadamer is concentrated on the problem of making experience the sole object of hermeneutics to the exclusion of persons and what they say, considered objectively. The problem with this is to express the role of interpretative practices philosophically if non-objectifying thinking is normative for hermeneutics. A solution is found by following up Gadamer’s insight into the influence of tradition on understanding, I show that tradition and its truth, as well as not being separable from the understanding subject's thinking, are also not detached from an author's intentions and are shared by human beings understanding one another. The transmissive nature of tradition discloses its own method for understanding what a person is saying and the ethical requirements of truth are forwarded by following that method.

Association of high-sensitivity C-reactive protein with de novo major depression

Background: Although there is cross-sectional evidence that changes in the immune system contribute to the pathophysiology of depression, longitudinal data capable of elucidating cause and effect relationships are lacking.

Aims: We aimed to determine whether subclinical systemic inflammation, as measured by serum high-sensitivity C-reactive protein (hsCRP) concentration, is associated with an increased risk of de novo major depressive disorder.

Method: Major depressive disorder was diagnosed using a clinical interview (SCID-I/NP). This is a retrospective cohort study; from a population-based sample of 1494 randomly selected women recruited at baseline during the period 1994-7, 822 were followed for a decade and provided measures of both exposure and outcome. Of these women, 644 (aged 20-84 years) had no prior history of depression at baseline and were eligible for analysis.

Results: During 5827 person-years of follow-up, 48 cases of de novo major depressive disorder were identified. The hazard ratio (HR) for depression increased by 44% for each standard deviation increase in log-transformed hsCRP (ln-hsCRP) (HR = 1.44, 95% CI 1.04-1.99), after adjusting for weight, smoking and use of non-steroidal anti-inflammatory drugs. Further adjustment for other lifestyle factors, medications and comorbidity failed to explain the observed increased risk for depression.

Conclusions: Serum hsCRP is an independent risk marker for de novo major depressive disorder in women. This supports an aetiological role for inflammatory activity in the pathophysiology of depression.

Georg Simmel, the stranger and the sociology of knowledge

The Simmelian stranger has been extensively studied and critiqued. This paper suggests that although this body of literature has contributed to a conceptual refinement of the category, its analysis confines itself to Simmel’s seminal essay on the stranger. A broader and deeper analysis of Simmel’s stranger is possible when we contextualise it within Simmel’s broader intellectual project and link it to his conception of historical knowledge, 10 his reflections on the third element, the cosmopolitan aesthetic sensibility and the genius. It is suggested that the affinities between the stranger and other ideas within his work allow us to ponder the contribution that Simmel can make to the debate on standpoint epistemologies.

Genome sequence of Ensifer arboris strain LMG 14919T, a microsymbiont of the legume Prosopis chilensis growing in Kosti, Sudan

Ensifer arboris LMG 14919T is an aerobic, motile, Gram-negative, non-spore-forming rod that can exist as a soil saprophyte or as a legume microsymbiont of several species of legume trees. LMG 14919T was isolated in 1987 from a nodule recovered from the roots of the tree Prosopis chilensis growing in Kosti, Sudan. LMG 14919T is highly effective at fixing nitrogen with P. chilensis (Chilean mesquite) and Acacia senegal (gum Arabic tree or gum acacia). LMG 14919T does not nodulate the tree Leucena leucocephala, nor the herbaceous species Macroptilium atropurpureum, Trifolium pratense, Medicago sativa, Lotus corniculatus and Galega orientalis. Here we describe the features of E. arboris LMG 14919T, together with genome sequence information and its annotation. The 6,850,303 bp high-quality-draft genome is arranged into 7 scaffolds of 12 contigs containing 6,461 protein-coding genes and 84 RNA-only encoding genes, and is one of 100 rhizobial genomes sequenced as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Root Nodule Bacteria (GEBA-RNB) project.