20 resultados para Existence of solutions
Resumo:
A methodology for the numerical solution of the forward kinematics problem of 6-RRCRR parallel manipulators with orthogonal non-intersecting RR-joint configuration is presented in this article. The inverse and forward kinematics solutions of such robots compared with that of parallel robots with orthogonal intersecting RR-joint or universal joint configurations are much more complicated due to the existence of dependent joint variables. The constraints of RR-joints are analysed and the numerical algorithm for the forward kinematics solution is assessed. Numerical results for the solution of the forward kinematics of 6-RRCRR parallel robot under study are provided to confirm the accuracy and efficiency of the procedure.
Resumo:
The vitrification solutions used in the cryopreservation of biological samples aim to minimize the deleterious formation of ice by dehydrating cells and promoting the formation of the glassy state of water. They contain a mixture of different cryoprotective agents (CPAs) in water, typically polyhydroxylated alcohols and/or dimethyl sulfoxide (DMSO), which can damage cell membranes. Molecular dynamics simulations have been used to investigate the behavior of pure DPPC, pure DOPC, and mixed DOPC-β-sitosterol bilayers solvated in a vitrification solution containing glycerol, ethylene glycol, and DMSO at concentrations that approximate the widely used plant vitrification solution 2. As in the case of solutions containing a single CPA, the vitrification solution causes the bilayer to thin and become disordered, and pores form in the case of some bilayers. Importantly, the degree of thinning is, however, substantially reduced compared to solutions of DMSO containing the same total CPA concentration. The reduction in the damage done to the bilayers is a result of the ability of the polyhydroxylated species (especially glycerol) to form hydrogen bonds to the lipid and sterol molecules of the bilayer. A decrease in the amount of DMSO in the vitrification solution with a corresponding increase in the amount of glycerol or ethylene glycol diminishes further its damaging effect due to increased hydrogen bonding of the polyol species to the bilayer headgroups. These findings rationalize, to our knowledge for the first time, the synergistic effects of combining different CPAs, and form the basis for the optimization of vitrification solutions. © 2014 Biophysical Society.
Resumo:
Characterization of the anticancer active compound trans-[PtII{(p-BrC
Resumo:
This work evaluates the effect of co-existence of a large volume fraction of δ-ferrite on the hot deformation and dynamic recrystallization (DRX) of austenite using comparative hot torsion tests on AISI 304 austenitic and 2205 duplex stainless steels. The comparison was performed under similar deformation conditions (i.e. temperature and strain rate) and also under similar Zener-Hollomon, Z, values. The torsion data were combined with electron backscatter diffraction (EBSD) analysis to study the microstructure development. The results imply a considerable difference between DRX mechanisms, austenite grain sizes and also DRX kinetics of two steels. Whereas austenitic stainless steel shows the start of DRX at very low strains and then development of that microstructure based on the necklace structure, the DRX phenomena in the austenite phase of duplex structure does not proceed to a very high fraction. Also, the DRX kinetics in the austenitic steel are much higher than the austenite phase of the duplex steel. The results suggest that at a similar deformation condition the DRX grain size of austenitic steel is almost three times larger than the DRX grains of austenite phase in duplex steel. Similarly, the ratio of DRX grain size in the austenitic to the duplex structure at the same Z values is about 1.5.
Resumo:
Abstract In this paper, a generalized model of hematopoiesis with delays and impulses isconsidered. By employing the contraction mapping principle and a novel type of impulsivedelay inequality, we prove the existence of a unique positive almost periodic solution of themodel. It is also proved that, under the proposed conditions in this paper, the unique positivealmost periodic solution is globally exponentially attractive. A numerical example is givento illustrate the effectiveness of the obtained results.