Porous Ti-Nb-Zr alloy through powder metallurgy for biomedical applications

This work investigated the structure and properties relationship, surface modification, biocompatibility and bioactivity of a porous Ti-Nb-Zr alloy. The porous alloy exhibited inter-connected porous structure, good biocompatibility and high mechanical strength with an elastic modulus close to that of bone. Porous Ti-Nb-Zr alloys are thus promising biomaterials for hard tissue replacement.

Structure-property relationships in plasticized solid polymer electrolytes

The addition of various kinds of plasticizers can enhance the conductivity of polymer electrolyte systems, in some cases by many orders of magnitude. The plasticizer may be a low molecular weight solvent, or be a low molecular weight polymer. As the plasticizer concentration increases there is an inevitable deterioration in material properties. In this work we have investigated the effect of plasticizer on the conductivity, thermal properties and matrial properties of a number of systems including urethane cross-linked polyethers and polyacrylates. In some of the systems, in particular the polyether electrolytes, the plasticizer acts to enhance conduction by acting as a cosolvent for the salt as well as increasing chain flexibility. Its efficacy is dependent on its structure and characteristics as a solvent. Although T_g is lowered in a close to linear fashion with increasing plasticizer content and thereby conductivity increased rapidly, the elastic modulus changes more slowly. This reflects the coupling of conduction to the local mobility of the molecular units of the combined solvent system and the relative decoupling of the mobility and glass transition from the material properties. In these systems the latter are a function mainly of the longer range structure of the polymer network. The changes in conductivity and materials properties are interpreted in terms of a configurational entropy model of the solution.

Mechanical properties of polyether-plasticiser-salt systems as polymer electrolytes

The mechanical properties of urethane crosslinked poly(ethylene oxide-co-propylene oxide) glyceryl ether-plasticiser (tetraethylene glycol dimethyl ether, or methylformamide)-salt (LiClO₄)-based polymer electrolytes have been studied. It was found that, with increasing concentration of salt, the elastic modulus and tensile strength of the materials unexpectedly decrease. This is interpreted in terms of a predominance of intramolecular coordination of the Li⁺ ions by the polymer.

Biomimetic modification of porous TiNbZr alloy scaffold for bone tissue engineering

Porous titanium (Ti) and Ti alloys are important scaffold materials for bone tissue engineering. In the present study, a new type of porous Ti alloy scaffold with biocompatible alloying elements, that is, niobium (Nb) and zirconium (Zr), was prepared by a space-holder sintering method. This porous TiNbZr scaffold with a porosity of 69% exhibits a mechanical strength of 67MPa and an elastic modulus of 3.9GPa, resembling the mechanical properties of cortical bone. To improve the osteoconductivity, a calcium phosphate (Ca/P) coating was applied to the surface of the scaffold using a biomimetic method. The biocompatibility of the porous TiNbZr alloy scaffold before and after the biomimetic modification was assessed using the SaOS2 osteoblast–like cells. Cell culture results indicated that the porous TiNbZr scaffold is more favorable for cell adhesion and proliferation than its solid counterpart. By applying a Ca/P coating, the cell proliferation rate on the Ca/P-coated scaffold was significantly improved. The results suggest that high-strength porous TiNbZr scaffolds with an appropriate osteoconductive coating could be potentially used for bone tissue engineering application.

Porous shape memory alloy scaffolds for biomedical applications : a review

The interest in using porous shape memory alloy (SMA) scaffolds as implant materials has been growing in recent years due to the combination of their unique mechanical and functional properties, i.e. shape memory effect and superelasticity, low elastic modulus combined with new bone tissue ingrowth ability and vasculariszation. These attractive properties are of great benefit to the healing process for implant applications. This paper reviews current state-of-the art on the processing, porous characteristics and mechanical properties of porous SMAs for biomedical applications, with special focus on the most widely used SMA nickel-titanium (NiTi), including (i) microstructural features, mechanical and functional properties of NiTi SMAs; (ii) main processing methods for the fabrication of porous NiTi SMAs and their mechanical properties and (iii) new-generation Ni-free, biocompatible porous SMA scaffolds.

Biomimetic porous titanium scaffolds for orthopaedic and dental applications

The development of artificial organs and implants for replacement of injured and diseased hard tissues such as bones, teeth and joints is highly desired in orthopedic surgery. Orthopedic prostheses have shown an enormous success in restoring the function and offering high quality of life to millions of individuals each year. Therefore, it is pertinent for an engineer to set out new approaches to restore the normal function of impaired hard tissues.

Over the last few decades, a large number of metals and applied materials have been developed with significant improvement in various properties in a wide range of medical applications. However, the traditional metallic bone implants are dense and often suffer from the problems of adverse reaction, biomechanical mismatch and lack of adequate space for new bone tissue to grow into the implant. Scientific advancements have been made to fabricate porous scaffolds that mimic the architecture and mechanical properties of natural bone. The porous structure provides necessary framework for the bone cells to grow into the pores and integrate with host tissue, known as osteointegration. The appropriate mechanical properties, in particular, the low elastic modulus mimicking that of bone may minimize or eliminate the stress-shielding problem. Another important approach is to develop biocompatible and corrosion resistant metallic materials to diminish or avoid adverse body reaction. Although numerous types of materials can be involved in this fast developing field, some of them are more widely used in medical applications. Amongst them, titanium and some of its alloys provide many advantages such as excellent biocompatibility, high strength-to-weight ratio, lower elastic modulus, and superior corrosion resistance, required for dental and orthopedic implants. Alloying elements, i.e. Zr, Nb, Ta, Sn, Mo and Si, would lead to superior improvement in properties of titanium for biomedical applications.

New processes have recently been developed to synthesize biomimetic porous titanium scaffolds for bone replacement through powder metallurgy. In particular, the space holder sintering method is capable of adjusting the pore shape, the porosity, and the pore size distribution, notably within the range of 200 to 500 m as required for osteoconductive applications. The present chapter provides a review on the characteristics of porous metal scaffolds used as bone replacement as well as fabrication processes of porous titanium (Ti) scaffolds through a space holder sintering method. Finally, surface modification of the resultant porous Ti scaffolds through a biomimetic chemical technique is reviewed, in order to ensure that the surfaces of the scaffolds fulfill the requirements for biomedical applications.

Understanding of hydrogel network formation and its application in the architecture of significantly enhanced hydrogel

An understanding of the physical hydrogel network formation has been obtained by dynamic rheological experiments. The evidence shows that the network formation turns out to be a nucleation-controlled process. It was found that there exists a critical temperature Tc; fiber branching is greatly enhanced when the network formation is performed in the regime of T<Tc (T, the final setting temperature). This finding enables the authors to build significantly enhanced gel networks. So far G′ (elastic modulus) of the hydrogel network has been enhanced by 187% while the formation period can be greatly shortened to only 1/20 of the previous process.

Spherulitic networks : from structure to rheological property

A finite element method based on ABAQUS is employed to examine the correlation between the microstructure and the elastic response of planar Cayley treelike fiber networks. It is found that the elastic modulus of the fiber network decreases drastically with the fiber length, following the power law. The power law of elastic modulus G′ vs the correlation length ξ obtained from this simulation has an exponent of −1.71, which is close to the exponent of −1.5 for a single-domain network of agar gels. On the other hand, the experimental results from multidomain networks give rise to a power law index of −0.49. The difference between −1.5 and −0.49 can be attributed to the multidomain structure, which weakens the structure of the overall system and therefore suppresses the increase in G′. In addition, when the aspect ratio of the fiber is smaller than 20, the radius of the fiber cross-section has a great impact on the network elasticity, while, when the aspect ratio is larger than 20, it has almost no effect on the elastic property of the network. The stress distribution in the network is uniform due to the symmetrical network structure. This study provides a general understanding of the correlation between microscopic structure and the macroscopic properties of soft functional materials.

Biodegradable Mg-Zr-Ca alloys for bone implant materials

Mg–Zr–Ca alloys were developed for new biodegradable bone implant materials. The microstructure and mechanical property of the Mg–xZr–yCa [x=0·5, 1·0% and y=1·0, 2·0% (wt-% hereafter)] alloys were characterised by optical microscopy, compressive and hardness tests. The in vitro cytotoxicity of the alloys was assessed using osteoblast-like SaOS₂ cells. The corrosion behaviour of these alloys was evaluated by soaking the alloys in simulated body fluid (SBF) and modified minimum essential medium (MMEM). Results indicated that the mechanical properties of the Mg–Zr–Ca are in the range of the mechanical properties of natural bone. The corrosion rate and biocompatibility decreases with the increase in the Ca content in the Mg–Zr–Ca alloys. The solutions of SBF and MMEM with the immersion of the Mg–Zr–Ca alloys show strong alkalisation. The Zr addition to the Mg–Zr–Ca alloys leads to an increase in the corrosion resistance, compressive strength and the ductility of the alloys, and a decrease in the elastic modulus of the Mg–Zr–Ca alloys.

Phase behavior and nanomechanical mapping of block ionomer complexes

Block ionomer complexes SSEBS-c-PCL were prepared, as a consequence of proton transfer from the sulfonic acid of sulfonated polystyrene-block- poly(ethylene-ran-butylene)-block-polystyrene (SSEBS) to the tertiary amine of a tertiary amine terminated poly(?-caprolactone) (APCL). The phase behavior of SSEBS-c-PCL was thoroughly investigated and the results showed that APCL in SSEBS-c-PCL displays unique crystallization behavior owing to the influence of interactions between the amine and sulfonic acid groups as well as the effects of confinement. Further, small-angle X-ray scattering study revealed that SSEBS-c-PCL displays a less ordered micro-phase structure compared to SSEBS. A quantitative mapping of mechanical properties at the nanoscale was achieved using peak force mode atomic force microscopy. It is found that the block ionomer complex possesses a higher average elastic modulus after complexation with crystallizable APCL. Additionally, the moduli for both hard and soft phases increase and the phase with higher modulus assignable to the hard SPS component shows much more pronounced changes after complexation, confirming that APCL interacts mainly with the SPS blocks. This provides an understanding of the composition and nanomechanical properties of these new block ionomer complexes and an alternative insight into the micro-phase structures of multi-phase materials.

Springback investigation in roll forming of a V-section

To have fuel efficient vehicles with a lightweight structure, the use of High Strength Steels (HSS) and Advanced High Strength Steels (AHSS) in the body of automobiles is increasing. Roll forming is used widely to form AHSS materials. Roll forming is a continuous process in which a flat strip is shaped to the desired profile by passing through numerous sets of rolls. Formability and springback are two major concerns in the roll forming of AHSS materials. Previous studies have shown that the elastic modulus (Young's modulus) of AHSS materials can change when the material undergoes plastic deformation and the main goal of this study is to numerically investigate the effect of a change in elastic modulus during forming on springback in roll forming. Experimental loading-unloading tests have been performed to obtain the material properties of TRIP 700 steel and incorporate those in the material model used in the numerical simulation of the roll forming process. The finite element simulations were carried out using MSC-Marc and two different element types, a shell element and a solid-shell element, were investigated. The results show that the elastic modulus diminution due to plastic strain increases the springback angle by about 60% in the simple V-section roll forming analyzed in this study. © (2014) Trans Tech Publications, Switzerland.

Improved contact load-bearing capacity of ultra-fine grained titanium : Multilayering and grading

The contact load-bearing response and surface damage resistance of multilayered hierarchical structured (MHSed) titanium were determined and compared to monolithic nanostructured titanium. The MHS structure was formed by combining cryorolling with a subsequent Surface Mechanical Attrition Treatment (SMAT) producing a surface structure consisted of an outer amorphous layer containing nanocrystals, an inner nanostructured layer and finally an ultra-fine grained core. The combination of a hard outer layer, a gradual transition layer and a compliant core results in reduced indentation depth, but a deeper and more diffuse sub-surface plastic deformation zone, compared to the monolithic nanostructured Ti. The redistribution of surface loading between the successive layers in the MHS Ti resulted in the suppression of cracking, whereas the monolithic nanograined (NG) Ti exhibited sub-surface cracks at the boundary of the plastic strain field. Finite element models with discrete layers and mechanically graded layersrepresenting the MHS system confirmed the absence of cracking and revealed a 38% decrease in shear stress in the sub-surface plastic strain field, compared to the monolithic NG Ti. Further, the mechanical gradation achieves a more gradual stress distribution which mitigates the interface failure and increases the interfacial toughness, thus providing strong resistance to loading damage. © 2014 Elsevier Ltd.

Nonlinear dynamic modeling of ionic polymer conductive network composite actuators using rigid finite element method

Ionic polymer conductive network composite (IPCNC) actuators are a class of electroactive polymer composites that exhibit some interesting electromechanical characteristics such as low voltage actuation, large displacements, and benefit from low density and elastic modulus. Thus, these emerging materials have potential applications in biomimetic and biomedical devices. Whereas significant efforts have been directed toward the development of IPMC actuators, the establishment of a proper mathematical model that could effectively predict the actuators' dynamic behavior is still a key challenge. This paper presents development of an effective modeling strategy for dynamic analysis of IPCNC actuators undergoing large bending deformations. The proposed model is composed of two parts, namely electrical and mechanical dynamic models. The electrical model describes the actuator as a resistive-capacitive (RC) transmission line, whereas the mechanical model describes the actuator as a system of rigid links connected by spring-damping elements. The proposed modeling approach is validated by experimental data, and the results are discussed. © 2014 Elsevier B.V. All rights reserved.

Microstructure and mechanical properties of silk from different components of the Antheraea pernyi cocoon

Silk fibres from different components of the Antheraea pernyi silkworm cocoon, namely peduncle, outer floss, and cocoon shells (outermost layer and pelade layer) were studied in detail to gain insights into the structure-property-function relationship. Among the fibres from different components, peduncle fibres are the softest with the largest viscoelastic lag, which may reduce the oscillation amplitude when a cocoon hangs on a twig. Fibres from the outermost layer are the toughest and have the largest breaking energy. Outer floss fibres have the highest content of sericin (about 11.98%) but their hardness and elasticity are intermediate. Pelade fibres are shape - preservable and stable with superior hardness and elasticity. The understanding of the properties of different silk fibres is essential for understanding their respective roles in the function of a silk cocoon and will also inspire new designs of protective materials under stringent environmental conditions.