Multi-cluster computing interconnection network performance modeling and analysis

The overall performance of a distributed system is often depends on the effectiveness of its interconnection network. Thus, the study of the communication networks for distributed systems is very important, which is the focus of this paper. In particular, we address the problem of fat-tree based interconnection networks performance modeling for multi-user heterogeneous multi-cluster computing systems. To this end, we present an analytical model and validate the model through comprehensive simulation. The results of the simulation demonstrated that the proposed model exhibits a good degree of accuracy for various system organizations and under different working conditions.

Modeling and analyses of the retirement of deteriorated structures

With the increasing stock of aging structures, the strategy to model and analyse the retirement of deteriorated structures is becoming a challenging research field. As the converse of construction of new projects, the retirement of constructed facilities puts forward some new management and economics themes as well as environmental issues or adds some new contents even though the same issues are faced in construction. This research aims to model and analyse the maintenance and demolition activities of constructed facilities from economic and environmental perspectives. Both cost and carbon dioxide of maintenance and demolition activities are formulated based on those of construction activities and applied to an empirical study on deteriorated bridges. Further modelling and analysis is investigated to elaborate the demolition stage of a structure. The developed modelling and analysis methodology may enable the decision maker to determine the retirement strategy for a deteriorated structure.

Tyrosine residues of the granulocyte colony-stimulating factor transmit proliferation and differentiation signals in murine bone marrow cells

Granulocyte colony-stimulating factor (G-CSF) is the major regulator of granulopoiesis and acts through binding to its specific receptor (G-CSF-R) on neutrophilic granulocytes. Previous studies of signaling from the 4 G-CSF-R cytoplasmic tyrosine residues used model cell lines that may have idiosyncratic, nonphysiological responses. This study aimed to identify specific signals transmitted by the receptor tyrosine residues in primary myeloid cells. To bypass the presence of endogenous G-CSF-R, a chimeric receptor containing the extracellular domain of the epidermal growth factor receptor in place of the entire extracellular domain of the G-CSF-R was used. A series of chimeric receptors containing tyrosine mutations to phenylalanine, either individually or collectively, was constructed and expressed in primary bone marrow cells from G-CSF-deficient mice. Proliferation and differentiation responses of receptor-expressing bone marrow cells stimulated by epidermal growth factor were measured. An increased 50% effective concentration to stimulus of the receptor Ynull mutant indicated that specific signals from tyrosine residues were required for cell proliferation, particularly at low concentrations of stimulus. Impaired responses by mutant receptors implicated G-CSF-R Y764 in cell proliferation and Y729 in granulocyte differentiation signaling. In addition, different sensitivities to ligand stimulation between mutant receptors indicated that G-CSF-R Y744 and possibly Y729 have an inhibitory role in cell proliferation. STAT activation was not affected by tyrosine mutations, whereas ERK activation appeared to depend, at least in part, on Y764. These observations have suggested novel roles for the G-CSF-R tyrosine residues in primary cells that were not observed previously in studies in cell lines.

Culture-based fisheries in non-perennial reservoirs of Sri Lanka: influence of reservoir morphometry and stocking density on yield

Culture-based fish yield in non-perennial reservoirs of Sri Lanka was related to reservoir morphometry and stocking density. The reservoirs were stocked mainly with fingerlings of one Chinese and three Indian major carp species, common carp, Cyprinus carpio L., and the genetically improved farmed tilapia strain of Nile tilapia, Oreochromis niloticus (L.), at four pre-determined species combinations and a range of stocking densities [SD (fingerlings ha⁻¹)]. Twenty-three reservoirs were harvested successfully at the end of the culture period of 2002–2003. Basic limnological and morphometric parameters, including shoreline development (D_L) and shoreline area ratio (R_LA), were estimated for each of the 23 reservoirs. Bray–Curtis similarity and non-metric multidimensional scaling using mean values of limnological data revealed that reservoirs could be ordinated into two major clusters, one with intact sample distribution due to similar trophic characteristics and the other with scattered sample distribution. Reservoirs in the cluster with similar trophic characteristics showed significant correlation (P < 0.05) between R_LA and total fish yield (Y). A multiple regression equation, Y = −693 + 4810 R_LA + 0.484 SD, was generated to estimate fish harvest in relation to SD.

Bread enriched with microencapsulated tuna oil increases plasma docosahexaenoic acid and total omega-3 fatty acids in humans

The aim of this study was to determine the acute and chronic effects of low doses of long chain (LC) n-3 polyunsaturated fatty acids (PUFA) (<100 mg per day) on plasma LC n-3 PUFA levels using a novel delivery form; bread containing microencapsulated tuna oil (MTO). Six omnivores (three men and three women) participated in the acute study, which involved ingesting a prototype MTO bread containing approximately 80 mg of LC n-3 PUFA/four slices. Plasma triacylglycerol fatty acid compositions were measured after an overnight fast and postprandially at 2 and 4 h. In the chronic study, 10 vegetarian subjects (nine men and one woman) consumed MTO bread at six to eight slices/day (comprising 60 mg of LC n-3 PUFA) as the only dietary source of these PUFA for three weeks. Fasting plasma total and phospholipid fatty acid compositions were measured at baseline and endpoint. In the acute study, the proportions of 22:6 n-3 and total n-3 PUFA in plasma triacylglycerol were significantly increased (P < 0.05). In the chronic study, the proportions of 20:5 n-3, 22:5 n‐3, 22:6 n-3, total n-3 PUFA in plasma, and 22:6 n-3 and total n-3 PUFA in plasma phospholipid fractions were significantly increased (P < 0.05) at the endpoint compared with the baseline. This study showed that a low dose of LC n-3 PUFA, consumed as MTO-enriched bread, was bioavailable, as measured by an increase in LC n-3 PUFA levels in the plasma of human subjects.

Modulation of tumor necrosis factor receptors 1 and 2 in chronic hepatitis B and C: The differences and implications in pathogenesis

Tumor necrosis factor (TNF) plays a role in the pathogenesis of chronic hepatitis B (CHB) and chronic hepatitis C (CHC). The difference in the cytokine responses between hepatitis B virus (HBV) and hepatitis C virus (HCV) infections may have implications in the pathogenesis of these diseases. We performed a comparative study to examine the possible differences in the TNF-TNF receptor (TNFR) response between CHB and CHC. We studied the cytokine levels of 38 patients with CHB, 40 patients with CHC and 9 patients with dual hepatitis B and C, and compared them with the baseline levels of 12 healthy controls. The plasma levels of TNF-, interferon-, interleukin (IL)-2, IL-4, IL-10 and soluble TNFR-1 and 2 (sTNFR-1 and 2) were quantified by enzyme-linked immunosorbent assays. The expression of TNFR-1 and 2 in liver tissues was examined in 30 cases of CHB and 15 cases of CHC by semiquantitative reverse transcription polymerase chain reaction. The results showed that sTNFR-1 levels correlated with liver inflammation in all patients, whereas this correlation was not found with sTNFR-2 or other cytokines. Liver inflammation indicators were higher in HCV RNA+ than in HCV RNA– CHC. Most significantly, sTNFR-1 levels correlated with liver inflammation in CHB, but not in CHC. However, the expression of TNFR-1 and 2 in liver was similar between CHB and CHC. These findings suggest that the TNFR signal transduction pathway is modulated differently in HBV and HCV infection.

Plasma coagulation factor VII activity and its corrlates in healthy men

Objective: The aim of this study was to investigate the plasma coagulation factor VII activity and its correlates in healthy Australian men.
Design: Cross-sectional study.
Setting: Free living subjects.
Subjects: A total of 139 healthy Australian males aged 20–55 y with widely varying intakes of individual fatty acids.
Outcome measures: The concentration of phospholipid fatty acids and the parameters of biochemistry were analysed by standard methods. Citrated plasma factor VII activity was measured by using the ACL 200 system with commercially available kits.
Results: In the stepwise multiple regression, controlled for age, body mass index and dietary groups, the two most important variables of factor VII activity were selected in the forward entry model with R2¼0.474 and Po0.0001 from 19 independent variables, which were significantly correlated with plasma factor VII activity in age-adjusted bivariate analysis where significance was considered at Po0.01. Plasma factor VII activity was strongly negatively correlated with prothrombin time (PT) (Std. Coeff. -0.550), and significantly positively correlated with plasma phospholipid (PL) stearic acid (Std. Coeff. 0.285).
Conclusions: Increased factor VII activity was associated with shortening of PT. All types of fatty-acid concentrations of PLs were
significantly positively correlated with factor VII activity; however, stearic acid was more potent than other fatty acids in healthy Australian men.
Sponsorship: Meat Research Corporation of Australia.

Performance modeling and analysis of heterogeneous meta-computing systems interconnection networks

The overall performance of a distributed system often depends on the effectiveness of its interconnection network. Thus, the study of the communication networks for distributed systems is very important, which is the focus of this paper. In particular, we address the problem of interconnection networks performance modeling for heterogeneous meta-computing systems. We consider the meta-computing system as a typical multi-cluster system. Since the heterogeneity is becoming common in such systems, we take into account network as well as cluster size heterogeneity to propose the model. To this end, we present an analytical network model and validate the model through comprehensive simulation. The results of the simulation demonstrated that the proposed model exhibits a good degree of accuracy for various system organizations and under different working conditions.

Comparative effects of tuna oil and salmon oil on liver lipid metabolism and fatty acid concentrations in rats

The comparative effect of tuna oil (TO) and salmon oil (SO) on the plasma and liver lipid and fatty acid compositions in Sprague Dawley rats was investigated. The total triacylglycerol (TG) and total cholesterol (TC) concentrations in liver was significantly decreased in the TO group; TG level in liver was also significantly decreased in the SO group. The mRNA expression of HMG-CoA reductase in liver was significantly down-regulated in the TO and SO groups relative to the control group. The plasma TG and TC were decreased in TO, but not in SO; plasma low-density lipoprotein and very low-density lipoprotein levels in TO and SO were decreased compared with the control group. The total n-3 polyunsaturated fatty acid (PUFA) in plasma and liver phospholipids was significantly elevated in the TO and SO. Docosahexaenoic acid (22:6n-3) and eicosapentaenoic acid (20:5n-3) in tissues were significantly increased in the TO and SO, respectively. In this study, TO had a more beneficial effect on liver TC and plasma TG, TC, high-density lipoprotein in rats than SO. The likely mechanism for lowering liver and plasma cholesterol by n-3 PUFA is to suppress the mRNA expression of gene encoding HMG-CoA reductase responsible for cholesterol biosynthesis.

PRACTICAL APPLICATIONS

The beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) from fish and fish oil on human health is derived from their role in modulating membrane lipid composition and affecting metabolic and signal-transduction pathways. In the present study, we demonstrated that n-3 PUFA, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) from tuna and salmon oils can be effectively incorporated into tissue membranes. Tuna oil rich in DHA has more beneficial effect on liver total cholesterol (TC) and plasma triglyceride, TC and HDL in rats than salmon oil, which is rich in EPA. The present data could provide information for the potential application of fish oils as components of functional food, and selected for fortification with different fish oils.

Multi-cluster computing interconnection network performance modeling and analysis

The overall performance of a distributed system often depends on the effectiveness of its interconnection network. Thus, the study of the communication networks for distributed systems–which is the focus of this paper–is very important. In particular, we address the problem of fat-tree based interconnection networks performance modeling for multi-user heterogeneous multi-cluster computing systems. To this end, we present an analytical model and validate the model through comprehensive simulation. The results of the simulation demonstrate that the proposed model exhibits a good degree of accuracy for various system organizations and under different working conditions. On the basis of the validated model, we propose an adaptive assignment function based on the existing heterogeneity of the system to minimize multi-user environment overhead.

Modeling and control of flatness in cold rolling mill using fuzzy petri nets

Today, having a good flatness control in steel industry is essential to ensure an overall product quality, productivity and successful processing. Flatness error, given as difference between measured strip flatness and target curve, can be minimized by modifying roll gap with various control functions. In most practical systems, knowing the definition of the model in order to have an acceptable control is essential. In this paper, a fuzzy Petri net method for modeling and control of flatness in cold rolling mill is developed. The method combines the concepts of Petri net and fuzzy control theories. It focuses on the fuzzy decision making problems of the fuzzy rule tree structures. The method is able to detect and recover possible errors that can occur in the fuzzy rule of the knowledge-based system. The method is implemented and simulated. The results show that its error is less than that of a PI conventional controller.

Meehl's crud factor, subjective wellbeing and religiosity : a critique

Researchers in the area of subjective wellbeing are now building on a body of research that spans more than three decades and includes many thousands of articles. It is time to move from exploratory studies to those based on accumulated psychometric understanding and theory. Two aspects of the article by Abdel-Khalek (2011) warrant attention from this perspective: the choice of scale and the issue of shared variance.