Letters to a young Catholic, by George Weigel

With the Twentieth World Youth Day in Cologne on 16-21 August, this year, scheduled to be the first overseas visit of Pope Benedict XVI, it is timely to consider the latest book from George Weigel, (perhaps best known for his Witness to Hope: The Biography of John Paul II) in which he composes 14 letters specifically aimed at young Catholics, who, like many of their older counterparts, may well be wondering what it means to be a Catholic today.<br /><br /><br />

Shaking hands on the fringe : negotiating the Aboriginal world at King George's Sound

In 1826 the British set up a garrison on the edges of an Aboriginal world at King George’s Sound, the site of present day Albany, Western Australia, with the aim of deterring the French from occupying the area.<br /><br />The British newcomers and the area’s Indigenous inhabitants, the King Ya-nup, came to share a small space, forcing both cultures to adapt in order to communicate and interact with one another. Within this sphere associations and friendships were formed that were as surprising as they were unique.<br /><br />This ethnographic history narrates several intimate cross-cultural stories of the developing relationships between British and Aboriginal individuals at King George’s Sound. The episodes recounted go beyond the common ‘friendly’ or ‘violent’ encounters, unearthing instead how and why particular King Ya-nup engaged with the British world, utilising the new presence to seeming advantage.<br /><br />Shaking Hands on the Fringe presents innovative history writing and beautifully crafted prose in the tradition of Greg Dening and other writers of ethnographic history.<br /><br />Despite the limited scope of the subject, the first two points liberate this book into a national (and international) interest: it is not a local book.<br />

Genome - wide association study identifies novel breast cancer susceptibility loci

Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate risks. To identify further susceptibility alleles, we conducted a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls, followed by a third stage in which 30 single nucleotide polymorphisms (SNPs) were tested for confirmation in 21,860 cases and 22,578 controls from 22 studies. We used 227,876 SNPs that were estimated to correlate with 77% of known common SNPs in Europeans at r² > 0.5. SNPs in five novel independent loci exhibited strong and consistent evidence of association with breast cancer (P < 10^-7). Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1). At the second stage, 1,792 SNPs were significant at the P < 0.05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach.

Nature's line : George Goyder over South Australia

A biographical work presenting 19th century South Australian surveyor general and founder of Darwin, George Goyder, as a significant figure in colonial environmental history. Focuses on tracing the growth of experience and insight which enabled him to map, as Goyder's line, his insight into the importance of rainfall variability.