Genome-wide association mapping in a wild avian population identifies a link between genetic and phenotypic variation in a life-history trait

Understanding the genetic basis of traits involved in adaptation is a major challenge in evolutionary biology but remains poorly understood. Here, we use genome-wide association mapping using a custom 50 k single nucleotide polymorphism (SNP) array in a natural population of collared flycatchers to examine the genetic basis of clutch size, an important life-history trait in many animal species. We found evidence for an association on chromosome 18 where one SNP significant at the genome-wide level explained 3.9% of the phenotypic variance. We also detected two suggestive quantitative trait loci (QTLs) on chromosomes 9 and 26. Fitness differences among genotypes were generally weak and not significant, although there was some indication of a sex-by-genotype interaction for lifetime reproductive success at the suggestive QTL on chromosome 26. This implies that sexual antagonism may play a role in maintaining genetic variation at this QTL. Our findings provide candidate regions for a classic avian life-history trait that will be useful for future studies examining the molecular and cellular function of, as well as evolutionary mechanisms operating at, these loci.

Ensidesapplikationers kodkvalitet och förvaltningsbarhet : En jämförelse av förvaltningsbarhet hos single-page applications utvecklade med AngularJS och React

Single-page applications have historically been subject to strong market forces driving fast development and deployment in lieu of quality control and changeable code, which are important factors for maintainability. In this report we develop two functionally equivalent applications using AngularJS and React and compare their maintainability as defined by ISO/IEC 9126. AngularJS and React represent two distinct approaches to web development, with AngularJS being a general framework providing rich base functionality and React a small specialized library for efficient view rendering. The quality comparison was accomplished by calculating Maintainability Index for each application. Version control analysis was used to determine quality indicators during development and subsequent maintenance where new functionality was added in two steps.   The results show no major differences in maintainability in the initial applications. As more functionality is added the Maintainability Index decreases faster in the AngularJS application, indicating a steeper increase in complexity compared to the React application. Source code analysis reveals that changes in data flow requires significantly larger modifications of the AngularJS application due to its inherent architecture for data flow. We conclude that frameworks are useful when they facilitate development of known requirements but less so when applications and systems grow in size.

Ensidesapplikationers kodkvalitet och förvaltningsbarhet : En jämförelse av förvaltningsbarhet hos single-page applications utvecklade med AngularJS och React

Single-page applications have historically been subject to strong market forces driving fast development and deployment in lieu of quality control and changeable code, which are important factors for maintainability. In this report we develop two functionally equivalent applications using AngularJS and React and compare their maintainability as defined by ISO/IEC 9126. AngularJS and React represent two distinct approaches to web development, with AngularJS being a general framework providing rich base functionality and React a small specialized library for efficient view rendering. The quality comparison was accomplished by calculating Maintainability Index for each application. Version control analysis was used to determine quality indicators during development and subsequent maintenance where new functionality was added in two steps. The results show no major differences in maintainability in the initial applications. As more functionality is added the Maintainability Index decreases faster in the AngularJS application, indicating a steeper increase in complexity compared to the React application. Source code analysis reveals that changes in data flow requires significantly larger modifications of the AngularJS application due to its inherent architecture for data flow. We conclude that frameworks are useful when they facilitate development of known requirements but less so when applications and systems grow in size. Sammanfattning: Ensidesapplikationer har historiskt sett påverkats av starka marknadskrafter som pådriver snabba utvecklingscykler och leveranser. Detta medför att kvalitetskontroll och förändringsbar kod, som är viktiga faktorer för förvaltningsbarhet, blir lidande. I denna rapport utvecklar vi två funktionellt ekvi-valenta ensidesapplikationer med AngularJS och React samt jämför dessa applikationers förvaltningsbarhet enligt ISO/IEC 9126. AngularJS och React representerar två distinkta angreppsätt på webbutveckling, där AngularJS är ett ramverk med mycket färdig funktionalitet och React ett mindre bibliotek specialiserat på vyrendering. Kvalitetsjämförelsen utfördes genom att beräkna förvaltningsbarhetsindex för respektive applikation. Versionshanteringsanalys användes för att bestämma andra kvalitetsindikatorer efter den initiala utvecklingen samt två efterföljande underhållsarbeten. Resultaten visar inga markanta skillnader i förvaltningsbarhet för de initiala applikationerna. I takt med att mer funktionalitet lades till sjönk förvaltnings-barhetsindex snabbare för AngularJS-applikationen, vilket motsvarar en kraftigare ökning i komplexitet jämfört med React-applikationen. Versionshanteringsanalys visar att ändringar i dataflödet kräver större modifikationer för AngularJS-applikationen på grund av dess förbestämda arkitektur. Utifrån detta drar vi slutsatsen att ramverk är användbara när de understödjer utvecklingen mot kända krav men att deras nytta blir begränsad ju mer en applikation växer i storlek.