First-principle data-driven models for assessment of motor disorders in Parkinson’s disease

Parkinson’s disease (PD) is an increasing neurological disorder in an aging society. The motor and non-motor symptoms of PD advance with the disease progression and occur in varying frequency and duration. In order to affirm the full extent of a patient’s condition, repeated assessments are necessary to adjust medical prescription. In clinical studies, symptoms are assessed using the unified Parkinson’s disease rating scale (UPDRS). On one hand, the subjective rating using UPDRS relies on clinical expertise. On the other hand, it requires the physical presence of patients in clinics which implies high logistical costs. Another limitation of clinical assessment is that the observation in hospital may not accurately represent a patient’s situation at home. For such reasons, the practical frequency of tracking PD symptoms may under-represent the true time scale of PD fluctuations and may result in an overall inaccurate assessment. Current technologies for at-home PD treatment are based on data-driven approaches for which the interpretation and reproduction of results are problematic.  The overall objective of this thesis is to develop and evaluate unobtrusive computer methods for enabling remote monitoring of patients with PD. It investigates first-principle data-driven model based novel signal and image processing techniques for extraction of clinically useful information from audio recordings of speech (in texts read aloud) and video recordings of gait and finger-tapping motor examinations. The aim is to map between PD symptoms severities estimated using novel computer methods and the clinical ratings based on UPDRS part-III (motor examination). A web-based test battery system consisting of self-assessment of symptoms and motor function tests was previously constructed for a touch screen mobile device. A comprehensive speech framework has been developed for this device to analyze text-dependent running speech by: (1) extracting novel signal features that are able to represent PD deficits in each individual component of the speech system, (2) mapping between clinical ratings and feature estimates of speech symptom severity, and (3) classifying between UPDRS part-III severity levels using speech features and statistical machine learning tools. A novel speech processing method called cepstral separation difference showed stronger ability to classify between speech symptom severities as compared to existing features of PD speech. In the case of finger tapping, the recorded videos of rapid finger tapping examination were processed using a novel computer-vision (CV) algorithm that extracts symptom information from video-based tapping signals using motion analysis of the index-finger which incorporates a face detection module for signal calibration. This algorithm was able to discriminate between UPDRS part III severity levels of finger tapping with high classification rates. Further analysis was performed on novel CV based gait features constructed using a standard human model to discriminate between a healthy gait and a Parkinsonian gait. The findings of this study suggest that the symptom severity levels in PD can be discriminated with high accuracies by involving a combination of first-principle (features) and data-driven (classification) approaches. The processing of audio and video recordings on one hand allows remote monitoring of speech, gait and finger-tapping examinations by the clinical staff. On the other hand, the first-principles approach eases the understanding of symptom estimates for clinicians. We have demonstrated that the selected features of speech, gait and finger tapping were able to discriminate between symptom severity levels, as well as, between healthy controls and PD patients with high classification rates. The findings support suitability of these methods to be used as decision support tools in the context of PD assessment.

Tillämpning och utvärdering av kriterier för eTjänstetydlighet och handlingsbarhet : Actability, eTjänstetydlighet, MA/SIMM

A sequence of actions in the world have influenced the information science, one of these actions is the lateral movement in how companies use their IT-systems. IT-systems today, in comparison to before, are used by companies to improve their relationship with their customers. Every year a big amount of money is spent on developing and improving IT-systems. That is why it is important to develop and create IT-systems that are clear, and which encourage, enable and simplify a user’s action. There are criteria to use in actability and “eTjänstetydlighet”. I have in this thesis used acknowledged criteria for actability and “eTjänstetydlighet” to analyze two IT-systems that are equal to each other. This is to show how companies can develop and adjust their IT-system so that they will match today’s point of view. I have also in this thesis chosen to evaluate the usage of criteria for “eTjänstetydlighet” and that is because no one has done that before. The result of this thesis gave Monster and Proffice measures for how to develop their IT-systems. The result of this thesis also gave indications of fuzziness when using criteria for “eTjänstetydlighet”, however, I was able to use the criteria the way they were supposed to be used to fulfill their purpose.

A conversão de D. José Brandão de Castro : a ação social de mediadores religiosos na Diocese de Propriá

This dissertation looked for to study the charisma of the religious mediator us " Movements of Christianity of Liberation " in the Diocese Sergipana of Propriá, during the decade from sixty to eighty. Centering our debate in the understanding of the social action, we have as main subject to understand the " poor " influence in the adoption of actions on the part of the mediators, in that public's favor, mainly in Fazenda Betume conflicts (1974) and of Santana dos Frades (1979). The hypotheses, we became pregnant that the mediators as D. José Brandão de Castro and the nun Maria Joana Hermínia exercised an important influence in the construction of the identity of the movements as CEBs, MEB and CPT in the area. Such influence was motivated by a conversion of the mediator D. Brandão, constituted starting from a relationship maintained between him and the members of the movements and proportionate for the critics and demands done by the popular ones. They resulted in actions in favor of the rural ones, what characterized the Church of Propriá as allied of the involved in the conflicts and no mere middleman. Before the collected material, we made use of the Analysis of Content using the poor " term " as analysis category, complemented by interviews done to members of the mentioned movements. Esta dissertação buscou estudar o carisma do mediador religioso nos “Movimentos de Cristianismo de Libertação” na Diocese Sergipana de Propriá, durante a década de sessenta a oitenta. Centrando nosso debate na compreensão da ação social, temos como questão principal entender a influência dos “pobres” na adoção de ações por parte do mediador, em favor desse público, principalmente nos conflitos da Fazenda Betume (1974) e de Santana dos Frades (1979). Como hipóteses, concebemos que os mediadores como D. José Brandão de Castro e a freira Maria Joana Hermínia exerceram uma importante influência na construção da identidade dos movimentos como as CEBs, o MEB e a CPT na região. Tal influência foi motivada por uma conversão do mediador D. Brandão, constituída a partir de uma relação mantida entre ele e os membros dos movimentos e proporcionada pelas críticas e demandas feita pelos populares. Elas resultaram em ações em favor dos campesinos, o que caracterizou a Igreja de Propriá como aliada dos envolvidos nos conflitos e não mera intermediária. Ante o material coletado, fizemos uso da Análise de Conteúdo utilizando o termo “pobre” como categoria de análise, complementada por entrevistas feitas à membros dos movimentos citados.

Spridning av innovation i högre utbildning : En studie av spridningen av Videochat vid Högskolan Dalarna

Syftet med denna uppsats har varit att beskriva och analysera spridningen av en innovation, Videochat, inom Högskolan Dalarna för att utifrån det lägga förslag på fortsatt arbete för att öka spridningen av Videochat. Frågorna som legat till grund för uppsatsen är: Vad är Videochattens spridningstakt inom Högskolan Dalarna? På vilka grunder har Videochat anammats inom Högskolan Dalarna? I de fall man inte har anammat Videochat, på vilka grunder man gjort det valet? Var och hur kan åtgärder sättas in för att stimulera spridningen av Videochat? Undersökningen har baserats på ett webbaserat frågeformulär bland Högskolan Dalarnas undervisande personal och frågorna i formuläret utarbetades med hjälp av förberedande intervjuer med nyckelpersoner inom Högskolan Dalarna. Undersökningen visar att användningen av Videochat har spridits olika långt på de olika akademierna och på två av fyra akademier anses det finnas ett behov av särskilda åtgärder för att stimulera spridningstakten. Den främsta anledningen till att börja använda Videochat är möjligheten att föreläsa för nätstudenter och campusstudenter samtidigt. Undersökningen visar samtidigt att anledningarna för att använda Videochat skiljer sig mellan de olika akademierna. Ett antal åtgärder föreslås för att stimulera spridning på de två akademier med lägst andel användare av Videochat där de viktigaste går ut på att öka kunskapen om Videochat och dess fördelar.

The Quest for CSR in Closedowns

This paper focuses on analysis of and suggestions for Corporate Social Responsibility (CSR) orienta- tion during the closedown process.The article addresses CSR considerations that adjust business strategies, which in turn change the Human Resource Management (HRM) focus. Our study fo- cuses on four best practice cases in Sweden, which are compared with three reported cases in the literature.All four best practice cases had a long notice period and socially responsible coordination of management and employees, which created adjusted corporate strategies.Three cases had the CSR orientation in the earliest stage, while the fourth case had this coordination during a later stage of the closedown process. We develop a model where we show that the scope for action increases if the CSR orientation and coordination of actions come early in the closedown process, due to the increased ability to adjust the business strategy and create a plan for outreach HRM activities and local community activities. 

Materialising bodies : there is nothing more material than a socially constructed body.

Over the last one of two decades, researchers within the physical education (PE) and sport pedagogy research frequently use the concept ‘the material body’. An initial purpose of this article is to explore what a concept of a ‘material body’ might mean. What other bodies are there? Who would dispute the materiality of bodies? I suggest that the use of a concept as ‘the material body’ suggests a hesitation before the radicalism of the linguistic turn in the sense that the concept ‘discourse’ does not include a material dimension. In this way ‘the material body’ relates to an interpretation of ‘the socially (or discursively) constructed body’ as void of matter. A further purpose with the article is to re-inscribe matter in the concept of ‘discourse’. This is done by way of discussing what theorists like Michel Foucault and, in particular, Judith Butler, has to say about the materiality of the body. In their writings, discourse should not be limited to spoken and/or written language. Rather, discourse is understood in terms of actions and events that create meanings—that matters. One conclusion of the article is that it is important to problematise the mundane view of discourse as ‘verbal interchange’ because it reinforces the promise of an objective knowledge that will eventually shed light on the ‘real’ body and the mysteries of sexual difference, what its origins are, what causes it. Another conclusion is that the PE and sport pedagogy research should pay less attention to the body as an object (what it ‘is’), and pay more attention to how the body matters, and e.g. how movements make bodies matter.