En analys av Joseph Conrads roman Heart of Darkness samt novell An outpost of progress

Denna studie är en analys av romanen Heart of Darkness (1902) och novellen An outpost ofprogress (1898) av Joseph Conrad (1857-1924) i syfte att undersöka berättelsernashuvudsakliga tematik ur en postkolonial infallsvinkel samt vad Conrads avsikt tycks ha varitmed porträtteringen av elfenbensagenten Kurtz. För att genomföra denna analys har jag gjorten närläsning av Heart of Darkness samt An outpost of progress och samtidigt tolkathändelseförloppen.Tolkningarna är delvis mina egna samt delvis baserat på tidigare forskning. Efter att hagenomfört dessa närläsningar är min slutsats att Conrads huvudsakliga avsikt var att skildaden mänskliga moralens förfall genom den ondskefulla girigheten. Det är denna girighet somhan definierar som det mörka i en människas hjärta. Genom framställningen av Kurtz visarhan exempel på detta samt hur farlig en skicklig retoriker kan vara.

Kung slår dam : våldsforskningsmetodologi i ett våldsamt jämställt Sverige

King captures queen. Methodology in research on violence in violently equal Sweden Research and debate on violence against women in a Swedish context is here discussed from a perspective that focuses on the different understandings and epistemological claims behind existing positions. I crystallize a dominant perspective on violence, centred around fragmentation/deviance, and a challenging feminist understanding, centred around coherence/normality. I relate these understandings to a wider set of methodological choices and epistemological claims within research on violence against women, captured in what I call a discourse on partner violence (fragmentation) and a feminist discourse on men’s violence against women (coherence). The article also examines the reactions, in media and academic life, that a quantitative study on men’s violence against women in Sweden provoked, Captured queen, men’s violence against women in equal Sweden. A prevalence study (Lundgren et al 2001). By applying a coherent methodological approach, stemming from the feminist discourse on violence against women, the study seems to have placed itself outside what was comprehensible for many voices in the debate (from media and the academic field). I discuss the hostile reactions the study aroused, in relation to its methodology and the above presented conflicting understandings that occupy the research field “violence against women”.

Large-scale metabolomic profiling identifies novel biomarkers for incident coronary heart disease

Analyses of circulating metabolites in large prospective epidemiological studies could lead to improved prediction and better biological understanding of coronary heart disease (CHD). We performed a mass spectrometry-based non-targeted metabolomics study for association with incident CHD events in 1,028 individuals (131 events; 10 y. median follow-up) with validation in 1,670 individuals (282 events; 3.9 y. median follow-up). Four metabolites were replicated and independent of main cardiovascular risk factors [lysophosphatidylcholine 18∶1 (hazard ratio [HR] per standard deviation [SD] increment = 0.77, P-value<0.001), lysophosphatidylcholine 18∶2 (HR = 0.81, P-value<0.001), monoglyceride 18∶2 (MG 18∶2; HR = 1.18, P-value = 0.011) and sphingomyelin 28∶1 (HR = 0.85, P-value = 0.015)]. Together they contributed to moderate improvements in discrimination and re-classification in addition to traditional risk factors (C-statistic: 0.76 vs. 0.75; NRI: 9.2%). MG 18∶2 was associated with CHD independently of triglycerides. Lysophosphatidylcholines were negatively associated with body mass index, C-reactive protein and with less evidence of subclinical cardiovascular disease in additional 970 participants; a reverse pattern was observed for MG 18∶2. MG 18∶2 showed an enrichment (P-value = 0.002) of significant associations with CHD-associated SNPs (P-value = 1.2×10-7 for association with rs964184 in the ZNF259/APOA5 region) and a weak, but positive causal effect (odds ratio = 1.05 per SD increment in MG 18∶2, P-value = 0.05) on CHD, as suggested by Mendelian randomization analysis. In conclusion, we identified four lipid-related metabolites with evidence for clinical utility, as well as a causal role in CHD development.