Trans-ethnic fine mapping highlights kidney-function genes linked to salt sensitivity

We analyzed genome-wide association studies (GWASs), including data from 71,638 individuals from four ancestries, for estimated glomerular filtration rate (eGFR), a measure of kidney function used to define chronic kidney disease (CKD). We identified 20 loci attaining genome-wide-significant evidence of association (p < 5 × 10(-8)) with kidney function and highlighted that allelic effects on eGFR at lead SNPs are homogeneous across ancestries. We leveraged differences in the pattern of linkage disequilibrium between diverse populations to fine-map the 20 loci through construction of "credible sets" of variants driving eGFR association signals. Credible variants at the 20 eGFR loci were enriched for DNase I hypersensitivity sites (DHSs) in human kidney cells. DHS credible variants were expression quantitative trait loci for NFATC1 and RGS14 (at the SLC34A1 locus) in multiple tissues. Loss-of-function mutations in ancestral orthologs of both genes in Drosophila melanogaster were associated with altered sensitivity to salt stress. Renal mRNA expression of Nfatc1 and Rgs14 in a salt-sensitive mouse model was also reduced after exposure to a high-salt diet or induced CKD. Our study (1) demonstrates the utility of trans-ethnic fine mapping through integration of GWASs involving diverse populations with genomic annotation from relevant tissues to define molecular mechanisms by which association signals exert their effect and (2) suggests that salt sensitivity might be an important marker for biological processes that affect kidney function and CKD in humans.

BEE COLONIES APPLIED TO MULTIPROCESSOR SCHEDULING

In order to achieve the high performance, we need to have an efficient scheduling of a parallelprogram onto the processors in multiprocessor systems that minimizes the entire executiontime. This problem of multiprocessor scheduling can be stated as finding a schedule for ageneral task graph to be executed on a multiprocessor system so that the schedule length can be minimize [10]. This scheduling problem is known to be NP- Hard.In multi processor task scheduling, we have a number of CPU’s on which a number of tasksare to be scheduled that the program’s execution time is minimized. According to [10], thetasks scheduling problem is a key factor for a parallel multiprocessor system to gain betterperformance. A task can be partitioned into a group of subtasks and represented as a DAG(Directed Acyclic Graph), so the problem can be stated as finding a schedule for a DAG to beexecuted in a parallel multiprocessor system so that the schedule can be minimized. Thishelps to reduce processing time and increase processor utilization. The aim of this thesis workis to check and compare the results obtained by Bee Colony algorithm with already generatedbest known results in multi processor task scheduling domain.

Retusch av landskapsfoto i annonser för turistmål : En kvantitativ undersökningkring den accepterade nivån av retusch

Etik kring bilder i annonser har diskuterats mycket, speciellt modell-, ochproduktbilder har kritiserats. Det tycks dock saknas forskning om acceptanskring efterbehandling av landskapsfotografier som ofta används vidmarknadsföring av turistmål. En webbenkätundersökning genomfördes medbildexempel för att undersöka vilken nivå av efterbehandling som ansågsverklighetstrogen, tilltalande och accepterbar i sådana annonser. Slutsatsenblev att fotografier där exponeringen korrigerats för att skapa en tydligare bildvar det mest accepterade. Skillnader i åsikter mellan åldrar, kön, de som haroch inte har tidigare erfarenhet av fotografi och retuschering diskuterades ochdet visade sig att kvinnor och de utan tidigare erfarenhet var lite mer kritiskatill efterbehandling. Det framkom att en del betraktare kan accepteraytterligare efterbehandling om den genomförs för att sälja en specifik känslaoch så länge inte betraktaren kan känna sig vilseledd.