A fuzzy rule-based decision support system for Duodopa treatment in Parkinson

A decision support system (DSS) was implemented based on a fuzzy logic inference system (FIS) to provide assistance in dose alteration of Duodopa infusion in patients with advanced Parkinson’s disease, using data from motor state assessments and dosage. Three-tier architecture with an object oriented approach was used. The DSS has a web enabled graphical user interface that presents alerts indicating non optimal dosage and states, new recommendations, namely typical advice with typical dose and statistical measurements. One data set was used for design and tuning of the FIS and another data set was used for evaluating performance compared with actual given dose. Overall goodness-of-fit for the new patients (design data) was 0.65 and for the ongoing patients (evaluation data) 0.98. User evaluation is now ongoing. The system could work as an assistant to clinical staff for Duodopa treatment in advanced Parkinson’s disease.

A web based decision support system for status assessment in advanced parkinson

The purpose of this work is to develop a web based decision support system, based onfuzzy logic, to assess the motor state of Parkinson patients on their performance in onscreenmotor tests in a test battery on a hand computer. A set of well defined rules, basedon an expert’s knowledge, were made to diagnose the current state of the patient. At theend of a period, an overall score is calculated which represents the overall state of thepatient during the period. Acceptability of the rules is based on the absolute differencebetween patient’s own assessment of his condition and the diagnosed state. Anyinconsistency can be tracked by highlighted as an alert in the system. Graphicalpresentation of data aims at enhanced analysis of patient’s state and performancemonitoring by the clinic staff. In general, the system is beneficial for the clinic staff,patients, project managers and researchers.

Optimised dose titration for Duodopatreatment based on simulation experiments– implementation in a decision supportsystem

The aim of this work was to design a set of rules for levodopa infusion dose adjustment in Parkinson’s disease based on a simulation experiments. Using this simulator, optimal infusions dose in different conditions were calculated. There are seven conditions (-3 to +3)appearing in a rating scale for Parkinson’s disease patients. By finding mean of the differences between conditions and optimal dose, two sets of rules were designed. The set of rules was optimized by several testing. Usefulness for optimizing the titration procedure of new infusion patients based on rule-based reasoning was investigated. Results show that both of the number of the steps and the errors for finding optimal dose was shorten by new rules. At last, the dose predicted with new rules well on each single occasion of majority of patients in simulation experiments.

Rule versus interaction function : evaluating regional aggregations of commuting flows in Sweden

The aim of this paper is to evaluate the performance of two divergent methods for delineating commuting regions, also called labour market areas, in a situation that the base spatial units differ largely in size as a result of an irregular population distribution. Commuting patterns in Sweden have been analyzed with geographical information system technology by delineating commuting regions using two regionalization methods. One, a rule-based method, uses one-way commuting flows to delineate local labour market areas in a top-down procedure based on the selection of predefined employment centres. The other method, the interaction-based Intramax analysis, uses two-way flows in a bottom-up procedure based on numerical taxonomy principles. A comparison of these methods will expose a number of strengths and weaknesses. For both methods, the same data source has been used. The performance of both methods has been evaluated for the country as a whole using resident employed population, self-containment levels and job ratios for criteria. A more detailed evaluation has been done in the Goteborg metropolitan area by comparing regional patterns with the commuting fields of a number of urban centres in this area. It is concluded that both methods could benefit from the inclusion of additional control measures to identify improper allocations of municipalities.

Världar av vackra kvinnor och våldsamma män : En analys av två fantasyromaner ur ett genusmedvetet perspektiv

This essay explores whether the gender constructions in Joe Abercrombie’s Best Served Cold and Juliet Marillier’s Daughter of the Forest question or contribute to existing gender categories. The analysis is performed using Raewynn Connell’s gender structure model, Brian Attebery’s theory of fantasy as a "fuzzy set" and Maria Nikolajeva’s schedule for stereotypical gender traits. Thus, both of the texts were analyzed to determine if their contents, structures and reader responses create opportunities or act limiting, how the main characters are portrayed and how the books various power-, production-, emotional- and symbolic relations look like. The result of the analysis is that both of the books portray patriarchal worlds, sexual division of labor, misogyny and gender-binding statements. The characters in Daughter of the Forest are quite stereotypical, with some traits that exceed their gender, whilst the characters in Best Served Cold are all portrayed with traditionally manly traits (even the female main character). Therefor one can say that Best Served cold’s female protagonist is the only element in the books that fully questions prevailing gender categories.

Geoprocessing journey-to-work data : delineating commuting regions in Dalarna, Sweden

Delineation of commuting regions has always been based on statistical units, often municipalities or wards. However, using these units has certain disadvantages as their land areas differ considerably. Much information is lost in the larger spatial base units and distortions in self-containment values, the main criterion in rule-based delineation procedures, occur. Alternatively, one can start from relatively small standard size units such as hexagons. In this way, much greater detail in spatial patterns is obtained. In this paper, regions are built by means of intrazonal maximization (Intramax) on the basis of hexagons. The use of geoprocessing tools, specifically developed for the processing ofcommuting data, speeds up processing time considerably. The results of the Intramax analysis are evaluated with travel-to-work area constraints, and comparisons are made with commuting fields, accessibility to employment, commuting flow density and network commuting flow size. From selected steps in the regionalization process, a hierarchy of nested commuting regions emerges, revealing the complexity of commuting patterns.

Module property verification : A method to plan and perform quality verifications in modular architectures

Modular product architectures have generated numerous benefits for companies in terms of cost, lead-time and quality. The defined interfaces and the module’s properties decrease the effort to develop new product variants, and provide an opportunity to perform parallel tasks in design, manufacturing and assembly. The background of this thesis is that companies perform verifications (tests, inspections and controls) of products late, when most of the parts have been assembled. This extends the lead-time to delivery and ruins benefits from a modular product architecture; specifically when the verifications are extensive and the frequency of detected defects is high. Due to the number of product variants obtained from the modular product architecture, verifications must handle a wide range of equipment, instructions and goal values to ensure that high quality products can be delivered. As a result, the total benefits from a modular product architecture are difficult to achieve. This thesis describes a method for planning and performing verifications within a modular product architecture. The method supports companies by utilizing the defined modules for verifications already at module level, so called MPV (Module Property Verification). With MPV, defects are detected at an earlier point, compared to verification of a complete product, and the number of verifications is decreased. The MPV method is built up of three phases. In Phase A, candidate modules are evaluated on the basis of costs and lead-time of the verifications and the repair of defects. An MPV-index is obtained which quantifies the module and indicates if the module should be verified at product level or by MPV. In Phase B, the interface interaction between the modules is evaluated, as well as the distribution of properties among the modules. The purpose is to evaluate the extent to which supplementary verifications at product level is needed. Phase C supports a selection of the final verification strategy. The cost and lead-time for the supplementary verifications are considered together with the results from Phase A and B. The MPV method is based on a set of qualitative and quantitative measures and tools which provide an overview and support the achievement of cost and time efficient company specific verifications. A practical application in industry shows how the MPV method can be used, and the subsequent benefits

Un estudio de La Sombra del Viento de Carlos RuizZafón desde una perspectiva de género

Esta tesina tiene el propósito de analizar las características de algunos de lospersonajes principales de La Sombra del Viento de Carlos Ruiz Zafón desde un punto de vistade género. El estudio se basa en diferentes teorías de género que pretenden funcionar comoherramientas para poder destacar las diferencias entre las descripciones femeninas y lasmasculinas que aparecen en la obra. Primero, definimos y concretamos el término género conla ayuda de las teorías de Yvonne Hirdman. En segundo lugar, presentamos la teoría deldualismo, de acuerdo con la cual Lena Gemzöe hace una división entre las cualidadesmasculinas y femeninas. El objetivo de nuestro estudio ha sido hacer un análisis de lascaracterísticas de algunos de los personajes principales de para demostrar si existenconstrucciones de identidad de género desde una perspectiva dualista. Como resultado denuestro estudio podemos afirmar que Zafón refuerza la división entre las cualidadesmasculinas y femeninas. Los personajes masculinos son descritos como fuertes, valientes,lógicos, intelectuales e independientes. Paralelamente, las mujeres son descritas como débiles,cobardes, intuitivas y dependientes. Además, consideramos que Zafón da a todos lospersonajes masculinos mayor espacio, estatus y protagonismo en el desarrollo de la historia.En todo momento, queda claro que Zafón crea de forma inconsciente el orden de género yrefuerza así las diferencias sexuales.

Manual and electroacupuncture for labour pain : study design of a longitudinal randomized controlled trial

Introduction. Results from previous studies on acupuncture for labour pain are contradictory and lack important information on methodology. However, studies indicate that acupuncture has a positive effect on women's experiences of labour pain. The aim of the present study was to evaluate the efficacy of two different acupuncture stimulations, manual or electrical stimulation, compared with standard care in the relief of labour pain as the primary outcome. This paper will present in-depth information on the design of the study, following the CONSORT and STRICTA recommendations. Methods. The study was designed as a randomized controlled trial based on western medical theories. Nulliparous women with normal pregnancies admitted to the delivery ward after a spontaneous onset of labour were randomly allocated into one of three groups: manual acupuncture, electroacupuncture, or standard care. Sample size calculation gave 101 women in each group, including a total of 303 women. A Visual Analogue Scale was used for assessing pain every 30 minutes for five hours and thereafter every hour until birth. Questionnaires were distributed before treatment, directly after the birth, and at one day and two months postpartum. Blood samples were collected before and after the first treatment. This trial is registered at ClinicalTrials.gov: NCT01197950.

Dynamic Fuzzy Logic Control of GeneticAlgorithm Probabilities

Genetic algorithms are commonly used to solve combinatorial optimizationproblems. The implementation evolves using genetic operators (crossover, mutation,selection, etc.). Anyway, genetic algorithms like some other methods have parameters(population size, probabilities of crossover and mutation) which need to be tune orchosen.In this paper, our project is based on an existing hybrid genetic algorithmworking on the multiprocessor scheduling problem. We propose a hybrid Fuzzy-Genetic Algorithm (FLGA) approach to solve the multiprocessor scheduling problem.The algorithm consists in adding a fuzzy logic controller to control and tunedynamically different parameters (probabilities of crossover and mutation), in anattempt to improve the algorithm performance. For this purpose, we will design afuzzy logic controller based on fuzzy rules to control the probabilities of crossoverand mutation. Compared with the Standard Genetic Algorithm (SGA), the resultsclearly demonstrate that the FLGA method performs significantly better.

A fuzzy logic controller for intestinal levodopa infusion in Parkinson’s disease

The aim of this work is to evaluate the fuzzy system for different types of patients for levodopa infusion in Parkinson Disease based on simulation experiments using the pharmacokinetic-pharmacodynamic model. Fuzzy system is to control patient’s condition by adjusting the value of flow rate, and it must be effective on three types of patients, there are three different types of patients, including sensitive, typical and tolerant patient; the sensitive patients are very sensitive to drug dosage, but the tolerant patients are resistant to drug dose, so it is important for controller to deal with dose increment and decrement to adapt different types of patients, such as sensitive and tolerant patients. Using the fuzzy system, three different types of patients can get useful control for simulating medication treatment, and controller will get good effect for patients, when the initial flow rate of infusion is in the small range of the approximate optimal value for the current patient’ type.

Intelligent Algorithms for a Hybrid FuelCell/Photovoltaic Standalone System : Simulation Of Hybrid FuelCell/Photovoltaic Standalone System

The Intelligent Algorithm is designed for theusing a Battery source. The main function is to automate the Hybrid System through anintelligent Algorithm so that it takes the decision according to the environmental conditionsfor utilizing the Photovoltaic/Solar Energy and in the absence of this, Fuel Cell energy isused. To enhance the performance of the Fuel Cell and Photovoltaic Cell we used batterybank which acts like a buffer and supply the current continuous to the load. To develop the main System whlogic based controller was used. Fuzzy Logic based controller used to develop this system,because they are chosen to be feasible for both controlling the decision process and predictingthe availability of the available energy on the basis of current Photovoltaic and Battery conditions. The Intelligent Algorithm is designed to optimize the performance of the system and to selectthe best available energy source(s) in regard of the input parameters. The enhance function of these Intelligent Controller is to predict the use of available energy resources and turn on thatparticular source for efficient energy utilization. A fuzzy controller was chosen to take thedecisions for the efficient energy utilization from the given resources. The fuzzy logic basedcontroller is designed in the Matlab-Simulink environment. Initially, the fuzzy based ruleswere built. Then MATLAB based simulation system was designed and implemented. Thenthis whole proposed model is simulated and tested for the accuracy of design and performanceof the system.