44 resultados para Georgia Warm Springs Foundation.

em CentAUR: Central Archive University of Reading - UK


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During the 1990s there was a major change in the state of the world's oceans. In particular, the North Atlantic underwent a rapid warming, with sea surface temperatures (SSTs) in the subpolar gyre region increasing by 1°C in just a few years. Associated with the changes in SST patterns were changes in the surface climate, in particular, a tendency for warm and dry conditions over areas of North America in all seasons, and warm springs and wet summers over areas of Europe. Here, the extent to which a climate prediction system initialized using observations of the ocean state is able to capture the observed changes in seasonal mean surface climate is investigated. Rather than examining predictions of the mid-1990s North Atlantic warming event itself, this study compares hindcasts started before and after the warming, relative to hindcasts that do not assimilate information. It is demonstrated that the hindcasts capture many aspects of the observed changes in seasonal mean surface climate, especially in North, South, and Central America and in Europe. Furthermore, the prediction system retains skill beyond the first year. Finally, it is shown that, in addition to memory of Atlantic SSTs, successfully predicting Pacific SSTs was likely important for the hindcasts to predict surface climate over North America.

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Glaciers occupy an area of similar to 1600 km(2) in the Caucasus Mountains. There is widespread evidence of retreat since the Little Ice Age, but an up-to-date regional assessment of glacier change is lacking. In this paper, satellite imagery (Landsat Thematic Mapper and Enhanced Thematic Mapper Plus) is used to obtain the terminus position of 113 glaciers in the central Caucasus in 1985 and 2000, using a manual delineation process based on a false-colour composite (bands 5, 4, 3). Measurements reveal that 94% of the glaciers have retreated, 4% exhibited no overall change and 2% advanced. The mean retreat rate equates to similar to 8 m a(-1), and maximum retreat rates approach similar to 38 m a(-1). The largest (>10 km(2)) glaciers retreated twice as much (similar to 12 m a(-1)) as the smallest (<1 km(2)) glaciers (similar to 6 m a(-1)), and glaciers at lower elevations generally retreated greater distances. Supraglacial debris cover has increased in association with glacier retreat, and the surface area of bare ice has reduced by similar to 10% between 1985 and 2000. Results are compared to declassified Corona imagery from the 1960s and 1970s and detailed field measurements and mass-balance data for Djankuat glacier, central Caucasus. It is concluded that the decrease in glacier area appears to be primarily driven by increasing temperatures since the 1970s and especially since the mid-1990s. Continued retreat could lead to considerable changes in glacier runoff, with implications for regional water resources.

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The development of high throughput techniques ('chip' technology) for measurement of gene expression and gene polymorphisms (genomics), and techniques for measuring global protein expression (proteomics) and metabolite profile (metabolomics) are revolutionising life science research, including research in human nutrition. In particular, the ability to undertake large-scale genotyping and to identify gene polymorphisms that determine risk of chronic disease (candidate genes) could enable definition of an individual's risk at an early age. However, the search for candidate genes has proven to be more complex, and their identification more elusive, than previously thought. This is largely due to the fact that much of the variability in risk results from interactions between the genome and environmental exposures. Whilst the former is now very well defined via the Human Genome Project, the latter (e.g. diet, toxins, physical activity) are poorly characterised, resulting in inability to account for their confounding effects in most large-scale candidate gene studies. The polygenic nature of most chronic diseases offers further complexity, requiring very large studies to disentangle relatively weak impacts of large numbers of potential 'risk' genes. The efficacy of diet as a preventative strategy could also be considerably increased by better information concerning gene polymorphisms that determine variability in responsiveness to specific diet and nutrient changes. Much of the limited available data are based on retrospective genotyping using stored samples from previously conducted intervention trials. Prospective studies are now needed to provide data that can be used as the basis for provision of individualised dietary advice and development of food products that optimise disease prevention. Application of the new technologies in nutrition research offers considerable potential for development of new knowledge and could greatly advance the role of diet as a preventative disease strategy in the 21st century. Given the potential economic and social benefits offered, funding for research in this area needs greater recognition, and a stronger strategic focus, than is presently the case. Application of genomics in human health offers considerable ethical and societal as well as scientific challenges. Economic determinants of health care provision are more likely to resolve such issues than scientific developments or altruistic concerns for human health.

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This paper summarizes the design, manufacturing, testing, and finite element analysis (FEA) of glass-fibre-reinforced polyester leaf springs for rail freight vehicles. FEA predictions of load-deflection curves under static loading are presented, together with comparisons with test results. Bending stress distribution at typical load conditions is plotted for the springs. The springs have been mounted on a real wagon and drop tests at tare and full load have been carried out on a purpose-built shaker rig. The transient response of the springs from tests and FEA is presented and discussed.

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A theory based healthy eating leaflet was evaluated against an existing publicly available standard leaflet. The intervention leaflet was designed to encourage healthy eating in 18-30 year olds and was developed by modifying an existing British Nutrition Foundation leaflet. The intervention leaflet targeted attitudes and self-efficacy. Participants (n=104) were randomly assigned either to the intervention, Foundation or a local food leaflet control condition. Cognitions were measured pre-intervention, immediately after reading the corresponding leaflet, and once again at two weeks follow-up. Critically, intentions to eat healthily were significantly greater at follow-up in the Intervention group compared to the other two groups, with the former leaflet also being perceived as more persuasive. The Intervention group also showed evidence of healthier eating at two weeks compared to the other two groups. Collectively the results illustrate the utility of a targeted theory-based approach.

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Shell aragonite δ18O values of unionid freshwater mussels are applied as a proxy for past river discharges in the rivers Rhine and Meuse, using a set of nine shells from selected climatic intervals during the late Holocene. A single Meuse shell derives from the Subboreal and its δ18O values are similar to modern values. The Rhine specimens represent the Subboreal, the Roman Warm Period and the Medieval Warm Period (MWP). These shells also show averages and ranges of aragonite δ18O values similar to modern specimens. This indicates that environmental conditions such as Rhine river dynamics, Alpine meltwater input and drought severity during these intervals were similar to the 20th century. These shells do not record subtle centennial to millennial climatic variation due to their relatively short lifespan and the large inter-annual and intra-seasonal variation in environmental conditions. However, they are very suitable for studying seasonal to decadal scale climate variability. The two shells with the longest lifespan appear to show decadal scale variability in reconstructed water δ18O values during the MWP, possibly forced by the North Atlantic Oscillation (NAO), which is the dominant mode of variability influencing precipitation regimes over Europe.