61 resultados para Controller designs
Filtro por publicador
- Aberdeen University (1)
- Aberystwyth University Repository - Reino Unido (4)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (2)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (6)
- Aquatic Commons (7)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (1)
- Archive of European Integration (1)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (1)
- Aston University Research Archive (19)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (5)
- Bioline International (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (24)
- Boston University Digital Common (2)
- Brock University, Canada (3)
- Bulgarian Digital Mathematics Library at IMI-BAS (6)
- CaltechTHESIS (7)
- Cambridge University Engineering Department Publications Database (81)
- CentAUR: Central Archive University of Reading - UK (61)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (11)
- Cochin University of Science & Technology (CUSAT), India (1)
- Collection Of Biostatistics Research Archive (3)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (2)
- Dalarna University College Electronic Archive (3)
- Deakin Research Online - Australia (76)
- Department of Computer Science E-Repository - King's College London, Strand, London (2)
- Digital Commons - Michigan Tech (4)
- Digital Commons @ DU | University of Denver Research (2)
- Digital Commons at Florida International University (7)
- DigitalCommons@The Texas Medical Center (7)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- DRUM (Digital Repository at the University of Maryland) (1)
- Duke University (4)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (1)
- FUNDAJ - Fundação Joaquim Nabuco (1)
- Greenwich Academic Literature Archive - UK (3)
- Harvard University (2)
- Helda - Digital Repository of University of Helsinki (2)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (80)
- Instituto Politécnico de Bragança (1)
- Instituto Politécnico do Porto, Portugal (4)
- Iowa Publications Online (IPO) - State Library, State of Iowa (Iowa), United States (1)
- Martin Luther Universitat Halle Wittenberg, Germany (1)
- Massachusetts Institute of Technology (5)
- Memorial University Research Repository (1)
- Ministerio de Cultura, Spain (3)
- National Aerospace Laboratory (NLR) Reports Repository (1)
- National Center for Biotechnology Information - NCBI (1)
- Nottingham eTheses (1)
- Open University Netherlands (5)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (48)
- Queensland University of Technology - ePrints Archive (176)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- RDBU - Repositório Digital da Biblioteca da Unisinos (1)
- Repositorio Académico de la Universidad Nacional de Costa Rica (1)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (2)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (1)
- Repositório Institucional da Universidade Federal do Rio Grande do Norte (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (60)
- SAPIENTIA - Universidade do Algarve - Portugal (4)
- Scielo España (1)
- Universidad Autónoma de Nuevo León, Mexico (1)
- Universidad Politécnica de Madrid (34)
- Universidade Complutense de Madrid (1)
- Universidade Federal do Rio Grande do Norte (UFRN) (2)
- Universitat de Girona, Spain (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (2)
- Université de Lausanne, Switzerland (2)
- Université de Montréal, Canada (1)
- University of Canberra Research Repository - Australia (1)
- University of Michigan (102)
- University of Queensland eSpace - Australia (29)
- University of Southampton, United Kingdom (3)
- University of Washington (2)
- WestminsterResearch - UK (2)
Resumo:
Recruitment of patients to a clinical trial usually occurs over a period of time, resulting in the steady accumulation of data throughout the trial's duration. Yet, according to traditional statistical methods, the sample size of the trial should be determined in advance, and data collected on all subjects before analysis proceeds. For ethical and economic reasons, the technique of sequential testing has been developed to enable the examination of data at a series of interim analyses. The aim is to stop recruitment to the study as soon as there is sufficient evidence to reach a firm conclusion. In this paper we present the advantages and disadvantages of conducting interim analyses in phase III clinical trials, together with the key steps to enable the successful implementation of sequential methods in this setting. Examples are given of completed trials, which have been carried out sequentially, and references to relevant literature and software are provided.