46 resultados para System test complexity
Filtro por publicador
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (4)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (19)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (12)
- Andina Digital - Repositorio UASB-Digital - Universidade Andina Simón Bolívar (1)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (11)
- Archive of European Integration (4)
- Aston University Research Archive (4)
- Biblioteca de Teses e Dissertações da USP (4)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (26)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (58)
- Biblioteca Virtual del Sistema Sanitario Público de Andalucía (BV-SSPA), Junta de Andalucía. Consejería de Salud y Bienestar Social, Spain (7)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (53)
- Brock University, Canada (8)
- Bucknell University Digital Commons - Pensilvania - USA (3)
- Bulgarian Digital Mathematics Library at IMI-BAS (2)
- CentAUR: Central Archive University of Reading - UK (46)
- CiencIPCA - Instituto Politécnico do Cávado e do Ave, Portugal (3)
- Clark Digital Commons--knowledge; creativity; research; and innovation of Clark University (1)
- Cochin University of Science & Technology (CUSAT), India (9)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (1)
- Consorci de Serveis Universitaris de Catalunya (CSUC), Spain (15)
- CORA - Cork Open Research Archive - University College Cork - Ireland (2)
- Dalarna University College Electronic Archive (20)
- Department of Computer Science E-Repository - King's College London, Strand, London (1)
- Digital Commons - Michigan Tech (3)
- Digital Commons - Montana Tech (1)
- Digital Commons @ DU | University of Denver Research (3)
- Digital Commons at Florida International University (4)
- Digital Peer Publishing (3)
- DigitalCommons - The University of Maine Research (1)
- DigitalCommons@The Texas Medical Center (13)
- DigitalCommons@University of Nebraska - Lincoln (2)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (1)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (45)
- Galway Mayo Institute of Technology, Ireland (1)
- Glasgow Theses Service (1)
- Helvia: Repositorio Institucional de la Universidad de Córdoba (1)
- Institutional Repository of Leibniz University Hannover (1)
- Instituto Politécnico do Porto, Portugal (38)
- Iowa Publications Online (IPO) - State Library, State of Iowa (Iowa), United States (8)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (2)
- Martin Luther Universitat Halle Wittenberg, Germany (3)
- National Center for Biotechnology Information - NCBI (9)
- Portal de Revistas Científicas Complutenses - Espanha (1)
- Publishing Network for Geoscientific & Environmental Data (21)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (2)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (6)
- Repositório da Produção Científica e Intelectual da Unicamp (6)
- Repositório digital da Fundação Getúlio Vargas - FGV (3)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (144)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (11)
- Scielo Saúde Pública - SP (58)
- Universidad de Alicante (5)
- Universidad del Rosario, Colombia (7)
- Universidad Politécnica de Madrid (68)
- Universidade do Minho (9)
- Universidade Federal do Pará (6)
- Universidade Federal do Rio Grande do Norte (UFRN) (1)
- Universita di Parma (1)
- Universitat de Girona, Spain (6)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (2)
- Université de Lausanne, Switzerland (47)
- Université de Montréal (1)
- Université de Montréal, Canada (5)
- University of Connecticut - USA (2)
- University of Michigan (59)
- University of Queensland eSpace - Australia (17)
- University of Southampton, United Kingdom (1)
- University of Washington (1)
Resumo:
The GPR30 is a novel estrogen receptor (ER) that is a candidate membrane ER based on its binding to 17beta estradiol and its rapid signaling properties such as activation of the extracellular-regulated kinase (ERK) pathway. Its distribution in the mouse limbic system predicts a role for this receptor in the estrogenic modulation of anxiety behaviors in the mouse. A previous study showed that chronic administration of a selective agonist to the GPR30 receptor, G-1, in the female rat can improve spatial memory, suggesting that GPR30 plays a role in hippocampal-dependent cognition. In this study, we investigated the effect of a similar chronic administration of G-1 on behaviors that denote anxiety in adult ovariectomized female mice, using the elevated plus maze (EPM) and the open field test as well as the activation of the ERK pathway in the hippocampus. Although estradiol benzoate had no effect on behaviors in the EPM or the open field, G-1 had an anxiolytic effect solely in the open field that was independent of ERK signaling in either the ventral or dorsal hippocampus. Such an anxiolytic effect may underlie the ability of G-1 to increase spatial memory, by acting on the hippocampus.