31 resultados para Diffusion Reaction Dynamics
Filtro por publicador
- KUPS-Datenbank - Universität zu Köln - Kölner UniversitätsPublikationsServer (1)
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- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (5)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (6)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (3)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (12)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archive of European Integration (2)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (1)
- Aston University Research Archive (24)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (11)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (199)
- Biblioteca Virtual del Sistema Sanitario Público de Andalucía (BV-SSPA), Junta de Andalucía. Consejería de Salud y Bienestar Social, Spain (2)
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- Bucknell University Digital Commons - Pensilvania - USA (3)
- CaltechTHESIS (1)
- CentAUR: Central Archive University of Reading - UK (31)
- CiencIPCA - Instituto Politécnico do Cávado e do Ave, Portugal (4)
- Cochin University of Science & Technology (CUSAT), India (5)
- Consorci de Serveis Universitaris de Catalunya (CSUC), Spain (62)
- Cor-Ciencia - Acuerdo de Bibliotecas Universitarias de Córdoba (ABUC), Argentina (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (1)
- Digital Commons - Michigan Tech (5)
- Digital Commons at Florida International University (9)
- Digital Peer Publishing (1)
- DigitalCommons - The University of Maine Research (1)
- DigitalCommons@The Texas Medical Center (4)
- Diposit Digital de la UB - Universidade de Barcelona (1)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (12)
- DRUM (Digital Repository at the University of Maryland) (1)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Instituto Nacional de Saúde de Portugal (1)
- Instituto Politécnico do Porto, Portugal (71)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (1)
- Martin Luther Universitat Halle Wittenberg, Germany (4)
- Massachusetts Institute of Technology (1)
- Memorial University Research Repository (1)
- National Center for Biotechnology Information - NCBI (16)
- Nottingham eTheses (9)
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- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (5)
- Repositório Científico da Universidade de Évora - Portugal (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (32)
- Repositório da Produção Científica e Intelectual da Unicamp (10)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (9)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (44)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (23)
- Scielo Saúde Pública - SP (50)
- Universidad de Alicante (2)
- Universidad del Rosario, Colombia (1)
- Universidad Politécnica de Madrid (11)
- Universidade Complutense de Madrid (2)
- Universidade do Minho (2)
- Universidade dos Açores - Portugal (1)
- Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP) (1)
- Universidade Federal do Rio Grande do Norte (UFRN) (1)
- Universitat de Girona, Spain (2)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (5)
- Université de Lausanne, Switzerland (19)
- Université de Montréal, Canada (5)
- Université Laval Mémoires et thèses électroniques (1)
- University of Michigan (1)
- University of Queensland eSpace - Australia (204)
- University of Washington (1)
Resumo:
Retrograde transport of NF-κB from the synapse to the nucleus in neurons is mediated by the dynein/dynactin motor complex and can be triggered by synaptic activation. The calibre of axons is highly variable ranging down to 100 nm, aggravating the investigation of transport processes in neurites of living neurons using conventional light microscopy. In this study we quantified for the first time the transport of the NF-κB subunit p65 using high-density single-particle tracking in combination with photoactivatable fluorescent proteins in living mouse hippocampal neurons. We detected an increase of the mean diffusion coefficient (Dmean) in neurites from 0.12 ± 0.05 µm2/s to 0.61 ± 0.03 µm2/s after stimulation with glutamate. We further observed that the relative amount of retrogradely transported p65 molecules is increased after stimulation. Glutamate treatment resulted in an increase of the mean retrograde velocity from 10.9 ± 1.9 to 15 ± 4.9 µm/s, whereas a velocity increase from 9 ± 1.3 to 14 ± 3 µm/s was observed for anterogradely transported p65. This study demonstrates for the first time that glutamate stimulation leads to an increased mobility of single NF-κB p65 molecules in neurites of living hippocampal neurons.