Human development in an evolutionary perspective

This article presents an evolutionary perspective to the study of human development. Some general assumptions for the study of development are discussed and the principal building blocks of evolutionary psychology are presented. One of them is that there is a universal human nature (which is modulate also by particular conditions of each context) and the cognitive architecture of human beings is the resulted of interactions between genes and environment. Based on those, and other assumptions, directions for the study of child development in an evolutionary stance are discussed, along with the considerations of context and development. Thus, it is assumed there is a relationship between phylogenies and ontogenetic development (the ontogenesis needs to be understood also as a product of evolution), considering the inseparability of biological, socio-cultural, cognitive emotional aspects that constitute this development. It has been concluded that the evolutionary developmental psychology has scientific relevance because it broadens our vision on human development.

Peer Tutors in the School of Medicine

Since 2003 the School of Medicine at the Universidad del Rosario in Bogotá, Colombia, offers to the students a program named Peer Tutors. The program’s objectives are: to generate a social interaction mechanism that favors knowledge construction side by side with advanced peers; to promote the development of ethical, moral and coexistence oriented values through an academic experience, and to generate a space to explore specific academic interests and teacher´s potential. This article presents the theoretic frame that supports the importance of social interaction in knowledge construction, as well as some indicators that allow a first appraisal of the program. Several achievements that account for the synergic value of an experience that not only fulfills the function of initiating a process of teaching formation and academic support, but that also builds a proactive attitude before learning, are highlighted.

Some Topics in Relation to José Celestino Mutis and Medicine

José Celestino Mutis showed different interest areas of study and worked in multiple knowledge fields: mathematics, mineralogy, astronomy, zoology and botanic, the one in which is best known. However, he was a medical doctor, whit profound an up to date knowledge. He studied at Sevilla University, and in the Royal College of Cadiz. He arrived to the “Nuevo Reino de Granada” as personal medical doctor of the the viceroy Pedro Messía de la Cerda and during 47 years, period of time he lived there, he always exercised his profession. We showed a special interest in the study of cinchona and the only work he published was El Arcano de la quina. He advised in public health many viceroys and he contributed in different fields but particularly in the prevention of smallpox by inoculation. He played a decisive role in the reopening of the medical school of the Colegio Mayor de Nuestra Señora del Rosario. Some of his achievements justifies the appellative “Father of the Medicine in Colombia”.

The use of insect cells to identify potent and selective inhibitors of the replication of the Dengue and Chikungunya viruses and unravel their molecular mechanism of action

Dengue and Chikungunya viruses cause the most important arthropod-borne viral infections for humans. These viruses are predominant in tropical and subtropical regions. In addition, these viruses are predominant in tropical and subtropical regions. Dengue mortality rate is around 1.2 to 3.5% and deaths due to chikungunya fever are around 1 in 1000; however, half of chikungunya-infected patients evolve into a chronic state that can persist for months up to years. There are no antiviral drugs available for DENV and CHIKV treatment and prevention. Moreover, vector control strategies have failed so far. Thus, the development of potent inhibitors for a broad spectrum of RNA viruses is urgently needed. We established and characterized a new embryonic insect cell line from Culex quinquefasciatus mosquito. Also we established the flaviviruses and alphavirus replication, both in C6/36 and Lulo insect cell lines, as well as in Vero cell line. In addition we carried out a reference compound library and reference panel of assays and data for DENV, which provides a benchmark for further studies. During this study, a panel of 9 antiviral molecules, with proven in vitro anti-dengue virus activity and that act at different stages of the DENV life cycle, was selected. Finally, Favipiravir or T-705, was identified as inhibitor in vitro and in vivo of alphaviruses and the mutation K291R in nsP4, which is responsible of the polymerase activity, was found as the mode of action in CHIKV. Interestingly, lysine in motif F1 is also highly conserved in positive-stranded RNA viruses and this might explain the broad spectrum of T-705 antiviral activity.