1 resultado para H.3.1 [Information Storage and Retrieval]
em Universidad del Rosario, Colombia
Filtro por publicador
- JISC Information Environment Repository (2)
- Repository Napier (1)
- Aberystwyth University Repository - Reino Unido (2)
- Academic Archive On-line (Stockholm University; Sweden) (1)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (2)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (2)
- Aquatic Commons (9)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (1)
- Archive of European Integration (48)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (1)
- Aston University Research Archive (6)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (11)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (9)
- Biblioteca Digital de la Universidad Católica Argentina (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (39)
- Boston University Digital Common (5)
- Brock University, Canada (5)
- Bulgarian Digital Mathematics Library at IMI-BAS (4)
- CaltechTHESIS (3)
- Cambridge University Engineering Department Publications Database (8)
- CentAUR: Central Archive University of Reading - UK (44)
- Center for Jewish History Digital Collections (1)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (34)
- Cochin University of Science & Technology (CUSAT), India (2)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (12)
- CORA - Cork Open Research Archive - University College Cork - Ireland (3)
- CUNY Academic Works (2)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (29)
- Department of Computer Science E-Repository - King's College London, Strand, London (1)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (1)
- Digital Commons at Florida International University (8)
- Digital Knowledge Repository of Central Drug Research Institute (2)
- Digital Peer Publishing (2)
- DigitalCommons@The Texas Medical Center (11)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (1)
- Duke University (8)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (4)
- eScholarship Repository - University of California (2)
- Greenwich Academic Literature Archive - UK (2)
- Harvard University (1)
- Helda - Digital Repository of University of Helsinki (11)
- Indian Institute of Science - Bangalore - Índia (66)
- INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES (IPEN) - Repositório Digital da Produção Técnico Científica - BibliotecaTerezine Arantes Ferra (1)
- Instituto Politécnico do Porto, Portugal (1)
- Massachusetts Institute of Technology (2)
- Ministerio de Cultura, Spain (3)
- National Center for Biotechnology Information - NCBI (4)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (5)
- Portal de Revistas Científicas Complutenses - Espanha (1)
- Publishing Network for Geoscientific & Environmental Data (140)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (32)
- Queensland University of Technology - ePrints Archive (131)
- Repositorio Académico de la Universidad Nacional de Costa Rica (2)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (2)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (96)
- SAPIENTIA - Universidade do Algarve - Portugal (1)
- School of Medicine, Washington University, United States (1)
- Universidad del Rosario, Colombia (1)
- Universidad Politécnica de Madrid (11)
- Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP) (2)
- Universitat de Girona, Spain (7)
- Université de Lausanne, Switzerland (5)
- Université de Montréal, Canada (4)
- University of Michigan (108)
- University of Queensland eSpace - Australia (7)
- University of Southampton, United Kingdom (2)
- WestminsterResearch - UK (2)
Resumo:
New hetaryl- and alkylidenerhodanine derivatives 3a-d, 3e, and 4a-d were prepared from heterocyclic aldehydes 1a-d or acetaldehyde 1e. The treatment of several rhodanine derivatives 3a-d and 3e with piperidine or morpholine in THF under reflux, afforded (Z)-5-(hetarylmethylidene)-2-(piperidin-1-yl) thiazol-4(5H)-ones and 2-morpholinothiazol-4(5H)-ones 5a-d, 6a-d, and (Z)-5-ethylidene-2-morpholinothiazol-4(5H)-one (5e), respectively, in good yields. Structures of all compounds were determined by IR, 1D and 2D NMR and mass spectrometry. Several of these compounds were screened by the U.S. National Cancer Institute (NCI) to assess their antitumor activity against 60 different human tumor cell lines. Compound 3c showed high activity against HOP-92 (Non-Small Cell Lung Cancer), which was the most sensitive cell line, with GI(50) = 0.62 mu M and LC50 > 100 mu M from the in vitro assays. In vitro antifungal activity of these compounds was also determined against 10 fungal strains. Compound 3e showed activity against all fungal strains tested, but showed high activity against Saccharomyces cerevisiae (MIC 3.9 mu g/mL).