Deletion Analysis of 15 exons located outside and inside a “Hot Spot” in the Duchenne Muscular Dystrophy gene in Duchenne’s Muscular dystrophy patients

Introduction. Duchenne and Becker Muscular Dystrophies (DMD/DMB) are X-linked recessive diseases characterized by progressive muscle weakness and wasting, loss of motor skills and death after the second decade of life. Deletions are the most prevalent mutations that affect the dystrophin gene, which spans 79 exons.Objective: Identify deletions on the dystrophin gene in 58 patients affected with DMD.Methods: Through multiplex PCR identify deletions on the dystrophin gene in 58 patients with DMD and observe the frequency of this mutation in our population.Results: We found deletions in 1.72% of patients (1 of 58 persons). Deletions were not the principal cause of disease in our population. It is possible that duplications and point mutations caused this illness in our patients.Conclusions: The frequency of deletions in the 15 exons analyzed from the dystrophin gene was low. The predominant types of mutation in our patients` samples were not deletions as has been observed in the literature worldwide, therefore, it is important to determine other types of mutations as are duplications and point mutations.

Modelling official and parallel exchange rates in Colombia under alternative regimes: a non-linear approach

We examine the long-run relationship between the parallel and the official exchange rate in Colombia over two regimes; a crawling peg period and a more flexible crawling band one. The short-run adjustment process of the parallel rate is examined both in a linear and a nonlinear context. We find that the change from the crawling peg to the crawling band regime did not affect the long-run relationship between the official and parallel exchange rates, but altered the short-run dynamics. Non-linear adjustment seems appropriate for the first period, mainly due to strict foreign controls that cause distortions in the transition back to equilibrium once disequilibrium occurs

Evaluating An Alternative To Finance Higher Education: Human Capital Contracts In Colombia.

Se presenta un ejercicio para la valuación de Contratos de Capital Humano (CCH), siguiendo a Palacios (2004), en el cual se utilizan datos del Observatorio Laboral para la Educación y su Encuesta de Seguimiento a Graduados–2007. El análisis se hace a través de un modelo Monteriano y uno de Splines para encontrar los pronósticos determinísticos del ingreso. Se encuentra que los retornos a la educación superior proveen un incentivo para la implementación de CCHs para financiar completamente los programas de las universidades públicas y parcialmente en las universidades privadas. Financiar los programas de las universidades privadas requiere más ayudas para hacer los contratos rentables para los inversionistas y atractivos para los estudiantes.