Nova et Vetera: Edición 3, febrero 3 - 9 de 2014

SISTEMA DE BIBLIOTECAS Y REPOSITORIO – OSCAR DÁVILA ROSARISTA DESTACADO EN ESPAÑA – MEDIO AMBIENTE – HUMEDALES – TORNEO PANAMERICANO DE DEBATE – AGENDA CULTURAL CENTRO DE BOGOTÁ – FACAO GARCÍA – FISIOTERAPIA – UNIDAD DE CUIDADO CRÍTICO – MÉDERI – HISTORIA FACULTAD DE MEDICINA CONFERENCIA UNIVERSIDAD DE SALAMANCA – LA IMPORTANCIA DE SABER INGLÉS

Nova et Vetera: Edición 7, marzo 3 - 9 de 2014

EMPRESARIO DEL AÑO – PARTICIPACIÓN DE LA MUJER EN LAS ELECCIONES AL CONGRESO – EL SOFÁ CON ALEXANDER TORRENEGRA – EMPRENDIMIENTO – CONSEJOS ESTUDIANTILES 2014 – RENDICIÓN PÚBLICA DE CUENTAS RECTORÍA – COLEGIOS OBJETIVO – RESULTADOS ADMISIONES – PERIODISMO TRANSMEDIA – FORO CANDIDATOS AL CONGRESO – POBREZA Y CORRUPCIÓN EN LOS PAÍSES

Synthesis, Antifungal and Antitumor Activity of Novel (Z)-5-Hetarylmethylidene-1,3-thiazol-4-ones and (Z)-5-Ethylidene-1,3-thiazol-4-ones

New hetaryl- and alkylidenerhodanine derivatives 3a-d, 3e, and 4a-d were prepared from heterocyclic aldehydes 1a-d or acetaldehyde 1e. The treatment of several rhodanine derivatives 3a-d and 3e with piperidine or morpholine in THF under reflux, afforded (Z)-5-(hetarylmethylidene)-2-(piperidin-1-yl) thiazol-4(5H)-ones and 2-morpholinothiazol-4(5H)-ones 5a-d, 6a-d, and (Z)-5-ethylidene-2-morpholinothiazol-4(5H)-one (5e), respectively, in good yields. Structures of all compounds were determined by IR, 1D and 2D NMR and mass spectrometry. Several of these compounds were screened by the U.S. National Cancer Institute (NCI) to assess their antitumor activity against 60 different human tumor cell lines. Compound 3c showed high activity against HOP-92 (Non-Small Cell Lung Cancer), which was the most sensitive cell line, with GI(50) = 0.62 mu M and LC50 > 100 mu M from the in vitro assays. In vitro antifungal activity of these compounds was also determined against 10 fungal strains. Compound 3e showed activity against all fungal strains tested, but showed high activity against Saccharomyces cerevisiae (MIC 3.9 mu g/mL).