Nova et Vetera: Edición 4, febrero 10 - 16 de 2014

EXTENSIÓN, RESPONSABILIDAD SOCIAL Y VOLUNTARIADO – RENDICIÓN DE CUENTAS – LECCIÓN INAUGURAL MAESTRÍA DE PERIODISMO – GIRA ACADÉMICA SUDESTE ASIÁTICO – FALLO DE LA HAYA – CHILE Y PERÚ – RICARDO ABELLO, ÁRBITRO CORTE PERMANENTE DE ARBITRAJE DE LA HAYA – CONVENIO UR CON UNIVERSIDAD DE TILBURG – CRÓNICA DE REVUELTAS Y LUCHAS – UR 360 – ÍNDICE DEPARTAMENTAL DE COMPETITIVIDAD – EL ROSARISMO – FIESTA PRO-BECA OSCAR OLIVELLA

Nova et Vetera: Edición 8, marzo 10-16 de 2014

emprendimiento empresarial – concurso nacional de semilleros de investigación – rutas sitp – rendición pública de cuentas rectoría – reformas curriculares – revista ágora convocatorias – maestría en dirección – crisis en ucrania – democracia y desplazamiento – estatua de fray cristóbal de torres – vida artificial e ingeniería

16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus

Background: The 16/6-idiotype (16/6-Id) of the human anti-DNA antibody was found to induce experimental lupus in naive mice, manifested by production of autoantibodies, leukopenia and elevated inflammatory markers, as well as kidney and brain involvement. We assessed behavior and brain pathology of naive mice injected intracerebra-ventricularly (ICV) with the 16/6-Id antibody. Methods: C3H female mice were injected ICV to the right hemisphere with the human 16/6-Id antibody or commercial human IgG antibodies (control). The mice were tested for depression by the forced swimming test (FST), locomotor and explorative activity by the staircase test, and cognitive functions were examined by the novel object recognition and Y-maze tests. Brain slices were stained for inflammatory processes. Results: 16/6-Id injected mice were cognitively impaired as shown by significant differences in the preference for a new object in the novel object recognition test compared to controls (P = 0.012). Similarly, the preference for spatial novelty in the Y-maze test was significantly higher in the control group compared to the 16/6-Id-injected mice (42% vs. 9%, respectively, P = 0.065). Depression-like behavior and locomotor activity were not significantly different between the16/6-Id-injected and the control mice. Immunohistochemistry analysis revealed an increase in astrocytes and microglial activation in the hippocampus and amygdala, in the 16/6-Id injected group compared to the control. Conclusions: Passive transfer of 16/6-Id antibodies directly into mice brain resulted in cognitive impairments and histological evidence for brain inflammation. These findings shed additional light on the diverse mosaic pathophysiology of neuropsychiatric lupus.

Nova et Vetera: Edición 16, Mayo 12 - 18 de 2014

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Interrater reliability of Alberta Infant Motor Scale in term and preterm born infants between 10 to 16 months age from Talca province - Chile

Purpose: To examine the ‘interrater reliability’ of the Alberta Infant Motor Scale (AIMS) in term and preterm born infants between 10 to 16 months age from Talca province, Maule Region - Chile. Subjects: 115 infants between 10 to 16 months age were incorporated to the study; 95 term born infants were attended in the local Health Centre in Talca City, and 20 preterm infants belonged to the Premature Infants Follow-Up Programme of Talca Regional Hospital. Methods: The motor behaviour of each infant was recorded and later it was assessed by two trained assessors using AIMS. It was obtained the total AIMS’ score and also from prone, supine, seated, and stand subscales. For ‘interrater reliability’ analysis it was used the Intraclass Coefficient of Correlation (ICC), the Standard Error of Measurement (SEM) and 95% limits of agreement. Results: The obtained ICC for the total scores AIMS were major than 0.94 (p<0.0002) for term and preterm born infants. The SEM of total scores was less than 3.1 points, higher than what was found in other similar studies. The 95% limits of agreement were +5.3 to -4.1 points and +7.7 to – 3.9 points in term and preterm born, respectively, revealing ‘interrater agreement’. Conclusion: The AIMS showed adequate ‘interrater reliable’ levels when was applied in Chilean term and preterm born from 10 to 16 month’s age.

Editorial y Contenido - Número 16, Junio 2009.

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Archivos Finales Desafíos 16

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16 años de la circunscripción nacional para Senado en Colombia: ¿dónde está el espacio de representación nacional?

Uno de los grandes cambios establecidos en la Constitución de 1991, y el principal dentro del sistema electoral, fue el establecimiento de la circunscripción nacional para la elección del Senado de la República. Como toda norma, tenía unos objetivos claros a la hora de su implementación que eran, sin duda alguna, visibles en las extensas discusiones dentro del proceso constituyente. Este artículo pretende evaluar uno de esos objetivos, específicamente el orientado a la búsqueda manifiesta de hombres y mujeres que forjasen proyectos políticos para todo el colectivo colombiano y que, al hacerlo, buscasen su elección en todo el territorio nacional y se autoconcibieran como líderes de toda la nación, superando el vínculo tradicionalmente regional que la historia ha visto pasar por el Senado en sus extensos 60 años de existencia. Para ello hemos sistematizado, descrito y analizado los resultados de los cinco eventos electorales que se han llevado a cabo para la elección del Senado desde 1991, con la ayuda de una revisión bibliográfica pertinente que permite comprender dichos resultados y ubicarlos en una esfera lógica de comportamiento de los candidatos escogidos en la circunscripción nacional. En este caso la explicación se inscribe dentro de la teoría de elección racional.-----One of the great changes established in the Constitution of 1991, and the main one within the electoral system, was the establishment of National Electoral District for the election of the Senate of the Republic. As with all laws, there were clear objectives at the time of its implementation that are, without doubt, visible in the extensive discussions within the constitutional process. This article intends, therefore, to evaluate one of these objectives, specifically the one focused on the public search for men and women who would forge political projects for Colombia as a whole and by doing so, would seek to be elected across the national territory and to design themselves as leaders of the whole country, thus overcoming the traditional regional links that history has seen pass through the Senate in its extensive 60 yeas of existence. In this light, the electoral results of the five electoral events that have taken place for the election of the Senate since 1991, have been automated, described, and analyzed, with the help of the relevant bibliographic review that allows to understand said results and place them within the logical sphere of the behavior of candidates chosen in the national district; in this case, the explanation is in line with the rational election theory.

Preliminares Desafíos 16

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Editorial Desafíos 16

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