Survival of European patients diagnosed with lymphoid neoplasms in 2000-2002: results of the HAEMACARE project

The European Cancer Registry-based project on hematologic malignancies (HAEMACARE), set up to improve the availability and standardization of data on hematologic malignancies in Europe, used the European Cancer Registry-based project on survival and care of cancer patients (EUROCARE-4) database to produce a new grouping of hematologic neoplasma(defined by the International Classification of Diseases for Oncology, Third Edition and the 2001/2008 World Health Organization classifications) for epidemiological and public health purposes. We analyzed survival for lymphoid neoplasms in Europe by disease group, comparing survival between different European regions by age and sex. Design and Methods Incident neoplasms recorded between 1995 to 2002 in 48 population-based cancer registries in 20 countries participating in EUROCARE-4 were analyzed. The period approach was used to estimate 5-year relative survival rates for patients diagnosed in 2000-2002, who did not have 5 years of follow up. Results: The 5-year relative survival rate was 57% overall but varied markedly between the defined groups. Variation in survival within the groups was relatively limited across European regions and less than in previous years. Survival differences between men and women were small. The relative survival for patients with all lymphoid neoplasms decreased substantially after the age of 50. The proportion of ‘not otherwise specified’ diagnoses increased with advancing age.Conclusions: This is the first study to analyze survival of patients with lymphoid neoplasms, divided into groups characterized by similar epidemiological and clinical characteristics, providing a benchmark for more detailed analyses. This Europe-wide study suggests that previously noted differences in survival between regions have tended to decrease. The survival of patients with all neoplasms decreased markedly with age, while the proportion of ‘not otherwise specified’ diagnoses increased with advancing age. Thus the quality of diagnostic work-up and care decreased with age, suggesting that older patients may not be receiving optimal treatment

La Mise en oeuvre préalable à la construction collaborative d’une séquence d’anglais à l’école élémentaire

La recherche présentée est issue d’une thèse en cours qui étudie la manière dont se nouent les relations entre les compétences culturelles et linguistiques au cours de séances de langue étrangère au cycle 3 de l’école primaire. Notre recherche s’appuie sur des données empiriques quantitatives et qualitatives et sur un cadre théorique articulant des concepts de didactique des langues et cultures (notamment, Aden, 2007; Gruson, 2007; Puren, 2002; Zarate, 1993), mais aussi de didactique des mathématiques dans une perspective comparatiste (entre autres, Brousseau, 1998; Sensevy, Mercier & Schubauer-Leoni, 2000; Sensevy & Mercier, 2007)

De la gestion des tâches à la (re)construction du savoir enseigné. Une analyse de l’activité enseignante en didactique des arts visuels (cours d’observation)

Dans notre effort de comprendre l’action enseignante a travers la relation entre l’objet enseigne et la gestion des taches, nous nous proposons de montrer dans cette contribution en quoi le rapport a un savoir est responsable de la cristallisation de certains gestes enseignants, d’une part, et de quelle façon les interactions en classe rendent compte de ce rapport, d’autre part. Les propriétés classiques de l’action (agentivité, intentionnalité/ causalité, descriptibilité) seront ici articulées a une perspective centrée sur le caractère déterminant de l’action. Nous rejoignons ici le traitement de l’intentionnalité comme « produit du processus interactionnel dans son ensemble » et non pas « comme une propriete des seules manifestations de l’agent » (Filliettaz, 2002: 187)

Combined Analysis of the Short-Term Effects of Photochemical Air Pollutants on Mortality within the EMECAM Project

In recent years, some epidemiologic studies have attributed adverse effects of air pollutants on health not only to particles and sulfur dioxide but also to photochemical air pollutants (nitrogen dioxide and ozone). The effects are usually small, leading to some inconsistencies in the results of the studies. Furthermore, the different methodologic approaches of the studies used has made it difficult to derive generic conclusions. We provide here a quantitative summary of the short-term effects of photochemical air pollutants on mortality in seven Spanish cities involved in the EMECAM project, using generalized additive models from analyses of single and multiple pollutants. Nitrogen dioxide and ozone data were provided by seven EMECAM cities (Barcelona, Gijón, Huelva, Madrid, Oviedo, Seville, and Valencia). Mortality indicators included daily total mortality from all causes excluding external causes, daily cardiovascular mortality, and daily respiratory mortality. Individual estimates, obtained from city-specific generalized additive Poisson autoregressive models, were combined by means of fixed effects models and, if significant heterogeneity among local estimates was found, also by random effects models. Significant positive associations were found between daily mortality (all causes and cardiovascular) and NO2, once the rest of air pollutants were taken into account. A 10 μg/m3 increase in the 24-hr average 1-day NO2 level was associated with an increase in the daily number of deaths of 0.43% [95% confidence interval(CI), –0.003–0.86%] for all causes excluding external. In the case of significant relationships, relative risks for cause-specific mortality were nearly twice as much as that for total mortality for all the photochemical pollutants. Ozone was independently related only to cardiovascular daily mortality. No independent statistically significant relationship between photochemical air pollutants and respiratory mortality was found. The results in this study suggest that, given the present levels of photochemical pollutants, people living in Spanish cities are exposed to health risks derived from air pollution