El Museo de Historia Natural, un espacio para la enseñanza de las ciencias

En la enseñanza de las ciencias con frecuencia se emplean diversas estrategias didácticas con el fin de fortalecer el proceso de aprendizaje de los estudiantes; una de éstas son las visitas a los museos de ciencias. Las visitas escolares a los museos han sido objeto de estudio de diferentes investigaciones, desde la cuales se espera, entre otras cosas, promover el reconocimiento de los museos como un apoyo en el proceso de enseñanza

Synthesis of unusual alpha-amino acids and study of the effect of their incorporation into antimicrobial peptides. Total synthesis of biactive marine natural products and analogues thereof

The principle theme of this thesis was the synthesis of bioactive compounds. To this end, this work was focus on two main projects. The first one, which was carried out in the Department of Chemistry of the University of Girona under the supervision of Dr Montserrat Heras, concerned the synthesis of new unnatural amino acids bearing a pyrimidine ring within their side chain for incorporation into the antimicrobial peptide BP100 following a rational design in order to improve its biological profile. On the other hand, the second chapter of this thesis was developed in collaboration with the Laboratoire de Chimie Organique (ESPCI-ParisTech, Paris, France) under the guidance of Pr Janine Cossy and Dr Arseniyadis. This chapter was centered on the total synthesis of three marine natural products with complex structures and interesting biological activities: acremolide B, (–) bitungolide F and lyngbouilloside.