A Data Mining Approach for the Identification of Adverse Drug Events (ADE) resulting from Drug-Drug Interactions (DDI) to improve pharmacovigilance

In the current study, epidemiology study is done by means of literature survey in groups identified to be at higher potential for DDIs as well as in other cases to explore patterns of DDIs and the factors affecting them. The structure of the FDA Adverse Event Reporting System (FAERS) database is studied and analyzed in detail to identify issues and challenges in data mining the drug-drug interactions. The necessary pre-processing algorithms are developed based on the analysis and the Apriori algorithm is modified to suit the process. Finally, the modules are integrated into a tool to identify DDIs. The results are compared using standard drug interaction database for validation. 31% of the associations obtained were identified to be new and the match with existing interactions was 69%. This match clearly indicates the validity of the methodology and its applicability to similar databases. Formulation of the results using the generic names expanded the relevance of the results to a global scale. The global applicability helps the health care professionals worldwide to observe caution during various stages of drug administration thus considerably enhancing pharmacovigilance

Ontology based Framework for News Extraction in Visual Media

Anticipating the increase in video information in future, archiving of news is an important activity in the visual media industry. When the volume of archives increases, it will be difficult for journalists to find the appropriate content using current search tools. This paper provides the details of the study we conducted about the news extraction systems used in different news channels in Kerala. Semantic web technologies can be used effectively since news archiving share many of the characteristics and problems of WWW. Since visual news archives of different media resources follow different metadata standards, interoperability between the resources is also an issue. World Wide Web Consortium has proposed a draft for an ontology framework for media resource which addresses the intercompatiblity issues. In this paper, the w3c proposed framework and its drawbacks is also discussed