Decreased (x1-Adrenergic Receptor Binding in the Cerebral Cortex and Brain Stem during Pancreatic Regeneration in Rats

purpose of this study was to investigate the role of brain al-adrenergic receptor binding in the rat model of pancreatic regeneration using 60-70% pancre:dectorny. The a, -adrenergic receptors kinetics was studied in the cerebral cor:cx and brain stem of sham operated . 72 It pan- crea(ectoinised and 7 days pancreatectomised rats. Scar chard analysis with I `I I lprazocin in cerebral cartes and brain stein showed a significant decrease (/' < 0.01). (P < 0.05) in maximal binding ( 1),,,,,) with it significant decrease (P < 0.001 ), ( P < 0.01) in the K,,in 72 It pancreatecto- raised rats compared with sham , respectively . Competition analysis in cerebral cortex and brain stem showed it shift in affinity during pancreatic regeneration . The sympathetic activity was decreased as indicated by the significantly de- increased norepinephrine level in the plasma (P < 0.001), cerebral cortex (P < 0.01) and brain stem (P < 0.001) of 72 h pancreatectomised rats compared to sham . Thus, from our results it is suggested that the central a, -adrenergic receptors have a functional role in the pancreatic regenera- Lion mediated through the sympathetic pathway.

Analysis of Fluctuations in the Early Universe Using Fokker-Planck Formalism

The thesis begins with a review of basic elements of general theory of relativity (GTR) which forms the basis for the theoretical interpretation of the observations in cosmology. The first chapter also discusses the standard model in cosmology, namely the Friedmann model, its predictions and problems. We have also made a brief discussion on fractals and inflation of the early universe in the first chapter. In the second chapter we discuss the formulation of a new approach to cosmology namely a stochastic approach. In this model, the dynam ics of the early universe is described by a set of non-deterministic, Langevin type equations and we derive the solutions using the Fokker—Planck formalism. Here we demonstrate how the problems with the standard model, can be eliminated by introducing the idea of stochastic fluctuations in the early universe. Many recent observations indicate that the present universe may be approximated by a many component fluid and we assume that only the total energy density is conserved. This, in turn, leads to energy transfer between different components of the cosmic fluid and fluctuations in such energy transfer can certainly induce fluctuations in the mean to factor in the equation of state p = wp, resulting in a fluctuating expansion rate for the universe. The third chapter discusses the stochastic evolution of the cosmological parameters in the early universe, using the new approach. The penultimate chapter is about the refinements to be made in the present model, by means of a new deterministic model The concluding chapter presents a discussion on other problems with the conventional cosmology, like fractal correlation of galactic distribution. The author attempts an explanation for this problem using the stochastic approach.