1 resultado para H3N8 subtype
em Cochin University of Science
Filtro por publicador
- Aberdeen University (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (13)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (1)
- Aquatic Commons (1)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (12)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (6)
- Aston University Research Archive (25)
- B-Digital - Universidade Fernando Pessoa - Portugal (1)
- Biblioteca de Teses e Dissertações da USP (1)
- Biblioteca Digital | Sistema Integrado de Documentación | UNCuyo - UNCUYO. UNIVERSIDAD NACIONAL DE CUYO. (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (40)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (17)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (3)
- Bioline International (4)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (155)
- Boston University Digital Common (3)
- Brock University, Canada (6)
- Bucknell University Digital Commons - Pensilvania - USA (1)
- CaltechTHESIS (4)
- Cambridge University Engineering Department Publications Database (1)
- CentAUR: Central Archive University of Reading - UK (22)
- Centro Hospitalar do Porto (2)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (13)
- Cochin University of Science & Technology (CUSAT), India (1)
- Coffee Science - Universidade Federal de Lavras (1)
- Collection Of Biostatistics Research Archive (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (5)
- Deakin Research Online - Australia (43)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (1)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Commons at Florida International University (1)
- DigitalCommons@The Texas Medical Center (29)
- DigitalCommons@University of Nebraska - Lincoln (2)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- Duke University (16)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (5)
- FUNDAJ - Fundação Joaquim Nabuco (1)
- Glasgow Theses Service (1)
- Helda - Digital Repository of University of Helsinki (15)
- Indian Institute of Science - Bangalore - Índia (10)
- Instituto Nacional de Saúde de Portugal (7)
- Memorial University Research Repository (1)
- National Center for Biotechnology Information - NCBI (68)
- Publishing Network for Geoscientific & Environmental Data (2)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (74)
- Queensland University of Technology - ePrints Archive (80)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (5)
- Repositório Institucional da Universidade de Aveiro - Portugal (2)
- Repositório Institucional da Universidade de Brasília (1)
- Repositório Institucional da Universidade Federal de São Paulo - UNIFESP (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (116)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (2)
- Savoirs UdeS : plateforme de diffusion de la production intellectuelle de l’Université de Sherbrooke - Canada (1)
- School of Medicine, Washington University, United States (1)
- Scielo España (1)
- Scientific Open-access Literature Archive and Repository (2)
- Universidad de Alicante (2)
- Universidad del Rosario, Colombia (12)
- Universidad Politécnica de Madrid (4)
- Universidade Complutense de Madrid (1)
- Universidade de Lisboa - Repositório Aberto (1)
- Universidade Federal do Pará (24)
- Universidade Federal do Rio Grande do Norte (UFRN) (5)
- Universidade Técnica de Lisboa (1)
- Université de Lausanne, Switzerland (6)
- Université de Montréal (2)
- Université de Montréal, Canada (28)
- University of Connecticut - USA (1)
- University of Queensland eSpace - Australia (35)
- University of Washington (2)
- WestminsterResearch - UK (1)
- Worcester Research and Publications - Worcester Research and Publications - UK (1)
Resumo:
Parasympathetic system plays an important role in insulin secretion from the pancreas. Cholinergic effect on pancreatic beta cells exerts primarily through muscarinic receptors. In the present study we investigated the specific role of muscarinic M1 and M3 receptors in glucose induced insulin secretion from rat pancreatic islets in vitro. The involvement of muscarinic receptors was studied using the antagonist atropine. The role of muscarinic MI and M3 receptor subtypes was studied using subtype specific antagonists. Acetylcholine agonist, carbachol, stimulated glucose induced insulin secretion at low concentrations (10-8-10-5 M) with a maximum stimulation at 10-7 M concentration. Carbachol-stimulated insulin secretion was inhibited by atropine confirming the role of muscarinic receptors in cholinergic induced insulin secretion. Both M1 and M3 receptor antagonists blocked insulin secretion induced by carbachol. The results show that M3 receptors are functionally more prominent at 20 mM glucose concentration when compared to MI receptors. Our studies suggest that muscarinic M1 and M3 receptors function differentially regulate glucose induced insulin secretion, which has clinical significance in glucose homeostasis.