Alterations in brainstem a2 adrenoreceptor activity in pyridoxine-deficient rat model of hypertension

Moderate pyridoxine deficiency in adult male Sprague-Dawley rats results in significant hypertension, associated with a general sympathetic stimulation , including an increase in the turnover of norepinephrine in the heart. Treatment of these rats with pyridoxine reversed blood pressure to normal within 24 h. Treatment of pyridoxine-deficient rats with clonidine or x-methyl dihydroxyphenylalanine (x-methyl DOPA) also reduced the blood pressure of these animals to normal . There was also a significant increase in the Bma, of high and low affinity [3H]p-amino-clonidine binding to crude synaptosomal membrane preparations of the brain stem of deficient rats indicating chronic underexposure of)(, adrenoreceptors to endogenous norepinephrin.

Chronic catheterization using vascular-access-port in rats: blood sampling with minimal stress for plasma catecholamine determination

Chronic catheterization is illustrated using vascular-access-port model SLA where the port is surgically placed subcutaneously on the back of the rat. The catheter is tunnelled to the neck and inserted into the jugular vein . Within 24 h rats showed normal blood pressure and blood samples were collected at intervals with minimal stress to the animals . A comparison of the plasma catecholamine of blood collected from vascular-access-ports with that obtained from decapitation indicates that there was minimal stress to the rats when blood was drawn through the vascular-access-port.

Performance of District Industries Centers in Kerala : An Application of augmented solow Model

This thesis "Entitled performance of district industries centres in kerala :An application of augmented solow model.The first chapter deals with evolution of approaches for promoting small scale production and the growth of small scale industries in india.the developing countries face the problems like sluggish growth capital shortages high levels of unemployment,enoromous rural-urban economic disparities regional inequalities increasing concentration of capital and chronic difficulities in the export sector.Review of literature and methodology of the study are presented in the second chapter. In the third chapter an attempt has been made to make an in-depth study of the emergence and growth of district of district industries centres.In the chapter four an attempt was made to study the organisational structure of DICs functions and responsibilities assigned to the functional managers and performance of the functionaries.