Strial capillary permeability following noise exposure in mice

A study of strial capillary permeability using fluorescent microspheres and immunohistochemistry in mice that do or do not exhibit a reduction in endocochlear potential following a single, intense noise exposure.

Evaluaton of a genetic marker within the organ of Corti of transgenic mice

This paper reviews a study to evaluate a genetic marker within the organ of Corti in transgenic mice for potential use in cell lineage studies.

Effects of antioxidant enzyme inhibitors on free radical levels in mice and possible clinical applications for decreasing ROS damage in the cochlea

This paper examines an experiment to determine if impairment of antioxident protective agents resulted in elevated ROS levels in mice.

Comparison of long term cochlear noise injury and age-related cochlear degeneration in mice

This paper studies and compares age related hearing loss and noise-induced hearing loss in mice, and the different cell types that are affected by aging and noise.

Marginal cell density in young and old CBA/J and CBA/CAJ mice

The goal of the present study was to compare aging characteristics of the cochlear lateral wall in inbred mouse strains (CBA/J and CBA/CaJ) having very different endocochlear potential (EP)-versus-age profiles to see which anatomic differences might predict their EP differences.

Synergistic effects of noise, kanamycin, and hyperoxia on ABR thresholds in CBA/J mice

Young CBA/J mice were exposed to noise, kanamycin, and/or hyperoxia by 30 days post-gestational age in order to determine if a synergistic effect exists on ABR thresholds.

The effects of noise exposure on nitric oxide synthase knockout mice

This paper studies the role of nitric oxide (NOS 1, NOS 2, and NOS 3 genes) in the mouse cochlea and in noise-induced hearing loss (NIHL). Mice genetically deficient of the NOS 2 and NOS 3 genes were protected from NIHL, indicating that one or both of these genes may be responsible for producing nitric oxide that damages the inner ear when exposed to harmful levels of noise.

Genetic influences on early cochlear vulnerability to noise and protection from noise by low-dose kanamycin in hybrid mice

Experiments evaluated both noise vulnerability and the extent of protection from noise by sub-chronic low-dose kanamycin in young F1 hybrids resulting from a cross between C57BL/6J and CBA/J inbred mice.

Cochlear protein expression in kanamycin treated mice

Experiments evaluated cochlear expression of key stress proteins in kanamycin and saline treated C57BL/6J and CBA/J mice using immunocytochemistry. A qualitative approach was used to assess immunoreactivity for HSP70, HSF-1, HO-1, and TNF-α as a function of strain and treatment.