Role of synuclein proteins in auditory function

The recent discovery of synuclein proteins in peripheral auditory tissues has prompted a closer examination of the role of these proteins in hearing. In the present study, auditory brainstem response thresholds of synuclein knockout mice are compared to wild type mice.

Interactions of alpha and beta synuclein proteins in auditory functioning

Alpha-synuclein is found in synaptic terminals at the base of both inner and outer hair cells, while the beta isoform is prominently localized to spiral ganglion neuron cell bodies. The present study assessed the role of beta-synuclein in auditory function, and potential interactions between isoforms.