Receipt from D.W. Bixby, Bookseller, St. Catharines

Receipt from D.W. Bixby, Bookseller, St. Catharines for payment on account, March 1887.

Receipt from D.W. Beadle Nursery Co. for payment on account

Receipt from D.W. Beadle Nursery Co. for payment on account, Oct. 5, 1887.

Letter to H.H. Collier of the Auditor’s Office in Austin, Texas from D.W. Fitch, publisher of the Houston Star Newspaper

Letter to H.H. Collier of the Auditor’s Office in Austin, Texas from D.W. Fitch (3 pages, handwritten), publisher of the Houston Star Newspaper. The letter is about newspaper business and personal matters. It is stated that Henry might go to Austin. This letter has been torn and taped. This does not affect the text, Feb. 28, 1841.

John O. McKellar (ship) certificates, 1952-1983.

The John O. McKellar was a ship that belonged to the Scott Misener fleet. The first ship named after McKellar was launched on Januaray 25, 1929, from Wallsend, England, and was bound for Sault St. Marie, Ontario. This ship became part of the Colonial Steamship Company in 1950, and in 1952 was renamed the J.G. Irwin when construction of a new John O. McKellar was completed. John Oscar McKellar was born on June 28, 1878 in Lobo Township, Middlesex County, west of London, Ont. He worked as a marine engineer, and became acquainted with Robert Scott Misener when the two were shipmates serving with the Algoma central fleet. In 1919, the two men joined forces to run a shipping company. Together, they purchased the wooden steamer "Simon Langell", and worked together on the ship for the next three years. Throughout his career with Misener's company, John McKellar served as Chief Engineer, then Marine Superintendent, and finally Secretary-Treasurer. He died on September 19, 1951.

Board of Trustees

Left to Right in clockwise fashion (Seated) B.P.R. Newman, C. Bruce Hill, Alan J. Earp (Provost), I.D. Buchanan, W.J. Marshall, Patrick Beard, H.C. Blenkhorn, H.W.M. Smith, Dr. James A. Gibson (President), D.W. Lathrop (69/70 chairman), E.R. Davey (68/69 chairman), Dr. C.A. Sankey (Chancellor), E.E. Mitchelson (Secretary), Dan Biggar, Mrs. J.J. Bench, M.L. Stwart, W.D. Chisholm, W.A. Thomas Left to Right (Standing) R.M. Schmon (Vice Chairman 69/70), E.S. Howard (Vice Chairman 69/70), S.S. MacInnes, QC (Vice Chairman 69/70)

Coat of Arms Patent

Dr. Gibson receiving the Letters Patent. l to right E.R. Davey, retiring Chairman of the Board of Trustees Dr. James Gibson, President D.W. Lathrop, Chairman of the Board of Trustees C.A. Sankey, Chancellor

Synthesis of fluorescent analogues of a-tocopherol as ligands for the human a-tocopherol transfer protein (a-TTP) /

To further understand in vivo localization and trafficking of a-tocopherol (a-Toe), the most biologically active form of vitamin E, between lipid environments, tocopherols are required that can be followed by teclu1iques such as confocal microscopy and fluorescence resonance energy transfer (FRET) assays. To this end, sixteen fluorescent analogues of a-tocopherol (la-d [(1)anthroy loxy -a-tocopherols, A O-a-Toes], 2a-d [w-nitro benzoxadiazole-a-tocopherols, NBD-aToes], 3a-d [w-dansyl-a-tocopherols, DAN-a-Toes], and 4a-d [w-N-methylanthranilamide-atocopherols, NMA-a-TocsD were prepared by substituting fluorescent labels at the terminus of w-functionalized alkyl chains extending from C-2 of the chroman ring while retaining key binding features of the natural ligand. These compounds were prepared starting from (S)-Trolox® acid VIa esterification, protection, and reduction producing the silyl-protected (S)-Trolox aldehyde that was coupled using Wittig chemistry to different w-hydroxyalkylphosphonium bromides. Reduction of the alkene generated the w-hydroxy functionalized 2-n-alkyl intermediates 9a-d having the necessary 2R stereochemistry. A series of functional group manipulations including mesylation, substitution with azide, and hydride reduction provided w-amino functionalized intermediates 12a-d as well. Coupling intermediates 9a-d and 12a-d with the selected fluorophores (9- anthracene carboxylic acid, 4-chloro-7-nitrobenz-2-oxa-l,3-diazole, 5- dimethylaminonapthalene-l-sulfonyl chloride, and I-methyl-2H-3,1-benzoxazine-2,4(1H)dione), followed by deprotection of the phenolic silyl group, gave the desired fluorescent ligands la-d, 2a-d, 3a-d and 4a-d in good yield. Assessment of their binding affinities with recombinant human a-tocopherol transfer protein (ha-TTP) utilizing fluorescent titration binding assays identified competent ligands for further use in protein studies. Compounds Id (C9-AO-a-Toc) and 2d (C9-NBD-a-Toc) both having nonyl alkyl chain extensions between the chromanol and fluorophore were shown to bind specifically to ha-TTP with dissociation constants (KdS) of approximately 280 nM and 55 nM respectively, as compared to 25 nM for the natural ligand 2R,4'R,^'R-a-tocophQxoL.

David William Smith House correspondence, 1798 [transcription]

The correspondence from D.W. [David William] Smith to President Peter Russell regarding Smith’s desire to sell a certain piece of property in Newark (now Niagara-on-the-Lake, Ont.) to be used as a location for a common grammar school. The notice gives a description of the building situated on the property as being adaptable for the use of a school. The Board of Survey convened in December 1798 to examine Smith’s property and gave an appropriate valuation of the properties and buildings Smith was offering for sale. Smith was the deputy surveyor general of lands for Upper Canada.

Niagara Parks Commission School of Gardening Graduation Program, 1956

The Niagara Parks Commission School of Gardening was organized in 1935 in order to help fill the Commission’s need for skilled gardeners to maintain the extensive parkland owned by the Commission. In 1959 the School was renamed the Niagara Parks Commission School of Horticulture. The name changed again in 1990 to the Niagara Parks Botanical Gardens and School of Horticulture to better reflect the development of the program.

Magazine article - Ice Brawl: A New Beverage Prompts a battle

An article from The Economist, May 22nd, 2004, discussing the ice wine industry. The article focuses on those producing ice cider as a rival to ice wine. Mr. Ziraldo is quoted when discussing rules and regulations associated with ice wine. There is also a handwritten note on the article that reads: "D. Ziraldo Donald I am very impressed. Ian Davidson"

Photograph - Robert DeVeaux Woodruff Band as a child in floral frame

Black and white photograph, 4 cm x 3 ½ cm, of Robert Band as a young child. This photograph is encased in a floral frame with a brass back. The back of the photo is inscribed with “Robert D. W. Band���.

Brass Surveying Compass

Brass Surveying Compass with a 6 1/2 inch diameter silvered brass dial signed E. and G.W. Blunt of New York. There is a fleur-de-lis at the north point and the outer needle ring is engraved 0-90 in four quadrants. There is an engraved central pattern, blue steel hand and brass lifter, shaped limbs and a brass dial cover. This belonged to Samuel DeVeaux Woodruff who was a Civil Engineer. It also belonged to R.D.W. Band who was also a Civil Engineer. Also, One 13 cm. brass spindle taper for the surveying compass, n.d