Indenture of Sale from Adam Hutt and wife Dorothy to Mathias Cairns, 1806

Indenture of bargain and sale from Adam Hutt and his wife Dorothy of Lincoln County regarding 27 acres to Mathias Cairns, of Stamford Township beginning at the northeast angle of Lot 29 of Stamford Township. This was registered on May 16, 1839 in Book U, folio 239 - instrument no. 12448, January 17, 1806.

Significance of DNA base excision repair in the maintenance of mitochondrial function in Saccharomyces cerevisiae /

Mitochondria have an important role in cell metabolism, being the major site of ATP production via oxidative phosphorylation (OXPHOS). Accumulation of mtDNA mutations have been linked to the development of respiratory dysfunction, apoptosis, and aging. Base excision repair (BER) is the major and the only certain repair pathway existing in mitochondria that is in responsible for removing and repairing various base modifications as well as abasic sites (AP sites). In this research, Saccharomyces cerevisiae (S. cerevisiae) BER gene knockout strains, including 3 single DNA glycosylase gene knockout strains and Ap endonuclease (Apn 1 p) knockout strain were used to examine the importance of this DNA repair pathway to the maintenance of respiratory function. Here, I show that individual DNA glycosylases are nonessential in maintenance of normal function in yeast mitochondria, corroborating with previous research in mammalian experimental models. The yeast strain lacking Apn 1 p activity exhibits respiratory deficits, including inefficient and significantly low intracellular ATP level, which maybe due to partial uncoupling of OXPHOS. Growth of this yeast strain on respiratory medium is inhibited, but no evidence was found for increased ROS level in Apn 1 p mitochondria. This strain also shows an increased cell size, and this observation combined with an uncoupled OXPHOS may indicate a premature aging in the Apnlp knockout strain, but more evidence is needed to support this hypothesis. However, the BER is necessary for maintenance of mitochondrial function in respiring S.cerevisiae.

Photograph - Dorothy Wetherald Rungeling, 1915

This photograph is of Dorothy Wetherald Rungeling in 1915. She is approximately 4 years old in this image. Dorothy is the adopted daughter of Canadian poet Agnes Ethelwyn Wetherald.

Photograph - Ethelwyn Wetherald, Dorothy Wetherald Rungeling and others in Treehouse, (c. 1916)

The photograph is of the "house in the trees" which was built on the Wetherald property by Ethelwyn's brother Sam sometime around 1911. The treehouse known as "Camp Shelbi" was a place of inspiration for Ethelwyn's poetry. A storm in 1921 caused the tree branch to break and the treehouse was destroyed.

Dorothy Rungeling fonds, 1887-2013, n.d.

Dorothy Rungeling was born in 1911 and raised in Fenwick, Ontario, by her adopted mother, Ethelwyn Wetherald. After graduating high school, she attended Fort Erie business College. She worked briefly in Toronto and then Hamilton, but eventually took a job with Brown Brothers’ Nursery in Pelham to be closer to home. Dorothy pursued many interests, learning to play the violin, saxophone and clarinet. She met her husband Charles at a local dance where she was playing. In 1939, they opened an automobile and farm machinery business in Welland. In their spare time, they were active in skeet and trap shooting, for which Dorothy won many trophies. In the early 1940s, Dorothy developed a passion for horses, training and showing them in addition to teaching riding at the Welland Riding Club, as well as judging at horse shows. By the late 1940s her interest in horses was waning, but she soon after discovered and pursued a new interest: flying. She joined the Welland Flying Club, obtained a flying licence, and in 1949 purchased her first plane. She proceeded to obtain a Commercial Pilot Licence in 1951, an Instructor’s Licence in 1953, and a Senior Commercial Licence in 1954. She participated in many air races in the 1950s, including the All Women’s International Air Races, the Women’s Transcontinental Air Races, and the Canadian Governor-General’s Cup Air Race. Some of the most notable races were the 1954 International Air Race, where Dorothy met with President Batista of Cuba, and the Governor-General’s Cup Air Race, where she won 1st place in 1953 and 1956 (and was the only woman competing). In 1958, she was also the first Canadian woman to solo pilot a helicopter. That same year she obtained her Airline Transport Licence. She also wrote several articles on aviation, contributing to publications such as Canadian Aviation and Air Facts, a U.S. aviation magazine. In addition to these articles, Dorothy authored several books about her life, as well as a selection of poems and articles by Ethelwyn Wetherald. As planes became more expensive, Dorothy spent less time flying, instead pursuing an interest in sailing. She and her husband bought a sailboat and became members of the Niagara-on-the-Lake Sailing Club. In 2003, Dorothy was awarded the Order of Canada for her accomplishments. She also wrote a regular column for the Voice of Pelham in 2012-2013, called A Century in Pelham. Dorothy celebrated her 100th birthday in 2011, and remains an active member of the community.

The Order of Canada Investiture Ceremony Program (Selection of Pages)

A selection of pages from the program for the Order of Canada Investiture Ceremony in 2003 when Dorothy Wetherald Rungeling was a recipient.

Letter - Adrienne Clarkson to Dorothy Wetherald Rungeling, 2003

A letter from Governor General of Canada, Adrienne Clarkson, to Dorothy Wetherald Rungeling. This correspondence is in response to a letter Dorothy Wetherald Rungeling had sent to Adrienne Clarkson. In the letter, Clarkson thanks Wetherald Rungeling for a copy her book "It's Fun to Grow Old!" and mentions "it was wonderful to hear you speak about your experiences as a pilot at the Order of Canada ceremony. I can assure you that you have had as great an impact on others (myself included) as we have had on you."

Letter - Jean Chretien to Dorothy Wetherald Rungeling, 2003

A letter from Prime Minister Jean Chretien to Dorothy Wetherald Rungeling, in congratulations of her appointment as a Member of the Order of Canada.

Letter - Premier Leslie M. Frost to Dorothy Rungeling, 1955

A letter from Premier Leslie M. Frost to Dorothy Rungeling wishing her the best in her upcoming All-Woman International Air Race from Washington, D.C. to Havana, Cuba. Mrs. Rungeling is the only Canadian entered in the race. Premier Frost also mentions that Mrs. Rungeling will likely have the chance to meet President Batista of Cuba.

Diagram of a Horse

A diagram of a horse, labelled and illustrated by Dorothy Rungeling.

Article - "Dorothy First at Wichita in 'Powder Puff' Derby"

An article in the Toronto Star written by Dorothy Rungeling during the 'Powder Puff' Derby. She is reporting from the Wichita, Kansas leg of the race and remarks about her time in California.

Photograph - Dorothy Rungeling with Plane

A photograph of Dorothy Rungeling in front of a plane with the Mack Trucks and Buses logo. This photograph is from her personal scrapbooks, the page is labelled "1956 International Air Race Hamilton to Havana".

Article - "Pelham's New Councillor A Woman of Many 'Firsts'", 1963

An article in the St. Catharines Standard announcing Dorothy Rungeling as a new member of council for Pelham Township. The article states, "She is the first woman to be nominated and elected to Pelham township council since it was formed in 1850,"

Photograph - Dorothy Rungeling and others at Airplane Hangar

A photograph of five men and Dorothy Rungeling standing at the entrance of an airplane hangar.

Article - "Stamp of Approval", 2010

An article discussing the accomplishments of Dorothy Rungeling and the announcement of a Canada Post stamp in her honour. Dorothy Rungeling is 99 at the time of the interview.