Dr. Roberta Robb

Professor of Economics

Letter which bears the letterhead ���Tisdale, Livingstone and Robb, Barristers, Simcoe, Ontario���

Letter which bears the letterhead ���Tisdale, Livingstone and Robb, Barristers, Simcoe, Ontario��� (3 pages, handwritten). It was sent to John I Mackenzie regarding contracts on work to be done at Long Point. The lawyers suggest that John Glover (contractor) speak to S.D. Woodruff. There is a note on the back to S.D. Woodruff from Mr. Mackenzie stating that he has no more to add but he notes that the fisherman are starting a petition. There is an envelope addressed to S.D. Woodruff with this letter, Feb. 5, 1875.

1998 Brock Baseball Team

1998 Brock Badger men's baseball team photo. Front Row (L to R): Bill Gillen, Ryan Villers, Greg Arbour, Mark Cheeseman, Andrew Tinnish, Rick Bottomley, Matt Fletcher, Brad Namtzu, Darryl Presley, Dan Pino, Grant Giffen, Mike Caruso, Mark Reilly Back Row (L to R): Jeff Lounsbury (Head Coach), Jayar Green, Creston Rudolph, Ryan Fisher, Jamie Trull, Stefan Strecker, Andrew Robb, Jeremy Walker, Ryan Johns, Matt Stezycki, Steve Lester, Fabio Del Rio, Jarrod Haase, Jess Dixon, Rick Falconer (Pitching Coach) Absent: Marc Purdy, Ian Bala, Marc LePage (Asst. Coach), Waybe Briggs-Jude (Asst. Coach)

Cellular Mechanisms of Resveratrol's Interaction with Mitochondrial Reactive Oxygen Species Metabolism

Resveratrol, a polyphenol found naturally in red wines, has attracted great interest in both the scientific community and the general public for its reported ability to protect against many of the diseases facing Western society today. While the purported health effects of resveratrol are well characterized, details of the cellular mechanisms that give rise to these observations are unclear. Here, the mitochondrial antioxidant enzyme Mn superoxide dismutase (MnSOD) was identified as a proximal target of resveratrol in vitro and in vivo. MnSOD protein and activity levels increase significantly in cultured cells treated with resveratrol, and in the brain tissue of mice given resveratrol in a high fat diet. Preventing the increase in MnSOD levels eliminates two of resveratrol���s more interesting effects in the context of human health: inhibition of proliferative cell growth and cytoprotection. Thus, the induction of MnSOD is a critical step in the molecular mechanism of resveratrol. Mitochondrial morphology is a malleable property that is capable of impeding cell cycle progression and conferring resistance against stress induced cell death. Using confocal microscopy and a novel ���cell free��� fusion assay it was determined that concurrent with changes in MnSOD protein levels, resveratrol treatment leads to a more fused mitochondrial reticulum. This observation may be important to resveratrol���s ability to slow proliferative cell growth and confer cytoprotection. Resveratrol's biological activities, including the ability to increase MnSOD levels, are strikingly similar to what is observed with estrogen treatment. Resveratrol fails to increase MnSOD levels, slow proliferative cell growth and confer cytoprotection in the presence of an estrogen receptor antagonist. Resveratrol's effects can be replicated with the specific estrogen receptor beta agonist diarylpropionitrile, and are absent in myoblasts lacking estrogen receptor beta. Four compounds that are structurally similar to resveratrol and seven phytoestrogens predicted to bind to estrogen receptor beta were screened for their effects on MnSOD, proliferative growth rates and stress resistance in cultured mammalian cells. Several of these compounds were able to mimic the effects of resveratrol on MnSOD levels, proliferative cell growth and stress resistance in vitro. Thus, I hypothesize that resveratrol interacts with estrogen receptor beta to induce the upregulation of MnSOD, which in turn affects cell cycle progression and stress resistance. These results have important implications for the understanding of RES���s biological activities and potential applications to human health.

Official Programme of the Niagara Falls Park Opening Celebration, 1885

Niagara Falls State Park is the oldest state park in the United States. It is also referred to as the State Reservation (this title appears on page 2 of the program). Frederick Olmstead was the landscape architect of the park and he also designed Central Park in New York City. In July 1885, the state of New York passed laws to issue bonds for the establishment of the Niagara Reservation. This park is a National Historic Landmark and covers over 400 acres. Close to 140 acres of that land is under water. In attendance at the opening were: the Governor of the State of New York, the officers of the State, members of the Niagara Falls Association of New York City and civil and military personnel. The commissioners at the time of the opening were: William Dorsheimer, Andrew H. Green, Martin B. Anderson, T. Hampden Robb and Sherman S. Rogers.

A. C. Thorburn Prescription Ledger

The gift plate in the front of the book indicates that the book is from Walker���s Drug Store, Niagara Falls, Ontario. Walker���s Drug Company was founded in 1925 by Ivan T. Walker. The dates of this book indicate that it is more likely to have come from A.C. Thorburn, Chemist and Druggist. A.C. Thorburn purchased Smith���s Pharmacy and Pursel and Company Dry Goods Store at the corner of Main Street and Lundy���s Lane in Niagara Falls, Ontario. In 1900, Pursel moved out and Thorburn���s Drug Store came into being. Ivan T. Walker, founder of Walker���s Drugs was employed by Thorburn Drugs in his teen years. The local doctors whose prescriptions are in the book include: J. H. McGarry; F.W.E. Wilson; C. F. Abraham; W.E. Olmsted; W.W. Thompson; Dr. Robb, dentist; Horace R. Elliot, physician and surgeon and Dr. Sutherland, eye, ear nose and throat specialist

Social competence following mild head injury and moderate traumatic brain injury: Investigating the neuropsychological relationships between arousal, social decision-making and depression

Client-directed long-term rehabilitative goals and life satisfaction following head injury emphasize the importance of social inclusion, rather than cognitive or physical, outcomes. However, very little research has explored the socio-emotional factors that pose as barriers to social reintegration following injury. This study investigates social barriers following head injury (i.e., decision-making - Iowa Gambling Task [IGT] and mood ��� depression) and possible amelioration of those challenges (through treatment) in both highly functioning university students with and without mild head injury (MHI) and in individuals with moderate traumatic brain injury (TBI). An arousal manipulation using emotionally evocative stimuli was introduced to manipulate the subject���s physiological arousal state. Seventy-five university students (37.6% reporting a MHI) and 11 patients with documented moderate TBI were recruited to participate in this quasi-experimental study. Those with head injury were found to be physiologically underaroused (on measures of electrodermal activation [EDA] and pulse) and were less sensitive to the negative effects of punishment (i.e., losses) in the gambling task than those without head injury, with greater impairment being observed for the moderate TBI group. The arousal manipulation, while effective, was not able to maintain a higher state of arousal in the injury groups across trials (i.e., their arousal state returned to pre-manipulation levels more quickly than their non-injured cohort), and, subsequently, a performance improvement was not observed on the IGT. Lastly, head injury was found to contribute to the relationship between IGT performance and depressive symptom acknowledgment and mood status in persons with head injury. This study indicates the possible important role of physiological arousal on socio- emotional behaviours (decision-making, mood) in persons with even mild, non-complicated head injuries and across the injury severity continuum.