Letter to J. Bradley from B.C.A. Gogy

Letter to J. Bradley from B.C.A. Gogy in the Office of the Adjutant General of Militia, Montreal (1 page, printed) regarding Bradley’s desire to obtain commission as a captain in the Quebec Artillery, Aug. 25, 1845

Letter to J.P. Bradley from B.C.A. Gogy

Letter to J.P. Bradley from B.C.A. Gogy in the Office of the Adjutant General of Militia, Montreal regarding procedures for applying for a captain’s commission in the militia (2 ½ pages, handwritten), Dec. 23, 1845.

Comparative study of bovine heart and bacillus subtilis cytochrome c oxidase vesicles and the influence of bulk pH on cytochrome c oxidase components

Studies on the steady state behavior of soluble cytochrome c oxidase are extensive. These studies have examined the influence of ionic strength and pH and may provide answers to questions such as the link between proton translocation and charge separation. The present study examined the influence of external bulk pH on ApH formation, biphasic kinetics, and steady state reduction of cytochromes c and a of cytochrome c oxidase in proteoliposomes. Bulk pH has an appreciable effect on ApH formation and steady state reduction levels of cytochromes c and 8. Bulk pH affected total Vmax and Km at the low affinity binding site of cytochrome c. This study also examined the influence of bovine serum albumin and free fatty acids on proton pumping activity in bovine heart proteoliposomes. Proton pumping activity decreased after treatment with BSA, and was subsequently reinstated after further treatment with FFA. Much study in the superfamily of haem/copper oxidases has recently been devoted to the bacterial oxidases. The present study has examined some protein composition characteristics and bioenergetic features of Bacillus subtilis cytochrome caa3 oxidase. Results provide evidence for the structural composition of the enzyme in relation to the covalently bound cytochrome c to the oxidas~. Bioenergetically, caa3 COV showed appreciable proton pumping activity. Steady state analysis of the caa3 COV showed significantly different cytochrome c and a reduction characteristics compared to the bovine enzyme.

Chemoenzymatic synthesis of amaryllidaceae alkaloids and their C-1 analogues : symmetry based approach to total synthesis of thebaine

Described herein is the chemoenzymatic total synthesis of several Amaryllidaceae constituents and their unnatural C-I analogues. A new approach to pancratistatin and related compounds will be discussed along with the completed total synthesis of 7 -deoxypancratistatin and trans-dihydrolycoricidine. Evaluation of all new C-l analogues as cancer cell growth inhibitory agents is described. The enzymatic oxidation of dibromobenzenes by Escherichia coli 1M 109 (pDTG60 1) is presented along with conversion of their metabolites to (-)-conduritol E. Investigation into the steric and functional factors governing the enzymatic dihydroxylation of various benzoates by the same organism is also discussed. The synthetic utility of these metabolites is demonstrated through their conversion to pseudo-sugars, aminocyclitols, and complex bicyclic ring systems. The current work on the total synthesis of some morphine alkaloids is also presented. Highlighted will be the synthesis of several model systems related to the efficient total synthesis of thebaine.

Photograph - B Squadron of the G.G.B.G. [Governor General’s Body Guard] at Niagara

Black and white photograph, mounted on board, 13 cm x 20 cm of the B Squadron of the G.G.B.G. [Governor General’s Body Guard] at Niagara.

Letter to Colonel Robert Nelles, Commander of the 4th Regiment of Lincoln Militia from Colonel Nathaniel Coffin of York

Letter to Colonel Robert Nelles, Commander of the 4th Regiment of Lincoln Militia from Colonel Nathaniel Coffin of York. His is enquiring about the post of collector at Niagara for his son-in-law Edward Pilkington. There is a small hole in this letter which affects the text slightly, Aug. 28, 1820.

Letter to Lieutenant Colonel Robert Nelles of the 4th Lincoln Militia from his daughter Mary Pilkington

Letter to Lieutenant Colonel Robert Nelles of the 4th Lincoln Militia from his daughter Mary Pilkington regarding family matters (1 page, double-sided, handwritten), Feb. 3, 1824.

Letter to Colonel R. Nelles, Commander of the 4th Lincoln Militia from Brook Young, Lieutenant Colonel at the Brigade Office in Drummondville

Letter to Colonel R. Nelles, Commander of the 4th Lincoln Militia from Brook Young, Lieutenant Colonel at the Brigade Office in Drummondville regarding instructions that he received from Colonel Kerley for the sedentary militia in this district to hold themselves in readiness to act at a moment’s warning if called to do so, May 27, 1838.

Letter to Lieutenant Colonel Brook Young, Brigade Major, Drummondville from H. Nelles, Lieutenant Colonel of the 4th Lincoln Militia

Letter to Lieutenant Colonel Brook Young, Brigade Major, Drummondville from H. Nelles, Lieutenant Colonel of the 4th Lincoln Militia stating that Colonel R. Nelles has requested him to say that most of the men did cheerfully comply and would be ready to act at a moment’s notice in defense of their Queen and country, June 12, 1838.

Letter to Colonel Nelles of the 4th Lincoln Militia in Grimsby from Apt. Military Secrets, Quebec

Letter to Colonel Nelles of the 4th Lincoln Militia in Grimsby from Apt. Military Secrets, Quebec. When this envelope is unfolded it contains the printed words “On his Majesty’s service” “The Ordnance Storekeeper” and “Military Secretary”. This item is badly stained and torn but text is not affected, Jan. 9, 1839.