Photograph - Lorenzo Lamas, Laura Dickson, Donald Ziraldo

A photograph of Lorenzo Lamas, Laura Dickson and Donald Ziraldo at the Winetasting Inn on the Park November 1986.

Human skeletal muscle pyruvate dehydrogenase phosphatase activity and expression : the effect of aerobic capacity

Activation of pyruvate dehydrogenase (PDH), which converts pyruvate into acetyl-CoA, is accomplished by a pair of specific phosphatases (PDP 1 & 2). A cross-sectional study investigating the effect of aerobic capacity on PDP activity and expression found that: 1) PDP activity and PDP! protein expression were positively correlated with most aerobic capacity measures in males (n=lS), but not females (n=12); 2) only males showed a positive correlation between PDP activity and PDPl protein expression (r=0.47; p=O.05), indicating that the increase in PDP activity in males is largely explained by increased PDPl protein expression, but that females rely on another level for PDP activity regulation; and 3) PDP} and Ela protein expression increase in unison when expressed relative to the E2 core. These data suggest that with increased aerobic capacity there is an increased capacity for carbohydrate oxidation through PDH, via El a, and an increased ability to activate PDH, via PDP, when exercising maximally.

Truman Raymond, Esq., M.D. - Obituary

An obituary describing the life of Dr. Truman Raymond of Welland County. The article recounts the many accomplishments of Dr. Raymond and his involvement in the Temperance movement. His sons are mentioned, including the predeceased Erastus B. Raymond, Esq., and his eldest son Lorenzo D. Raymond , Esq, who is appointed to the office of Clerk of Peace for Welland County. Dr. Raymond resided with his son Lorenzo at the time of his death.