Dr. Michael Hornyansky

Professor of English Language and Literatre, Michael Hornyansky, in 1989. Dr. Hornyansky was one of the original Brock faculty members.

Dr. Michael Hornyansky

Professor of English Language and Literatre, Michael Hornyansky, in 1989. Dr. Hornyansky was one of the original Brock faculty members.

Michael Hornyansky

Michael Hornyansky was head of the Department of English at Brock and was one of the first 7 faculty members.

Towards the enantioselective synthesis of lycoricidine alkaloids /

Two efficient, regio- and stereo controlled synthetic approaches to the synthesis of racemic analogs of pancratistatin have been accomplished and they serve as the model systems for the total synthesis of optically active 7-deoxy-pancratistatin. In the Diels-Alder approach, an efficient [4+2] cycloaddition of 3,4-methylenedioxyco- nitrostyrene with Danishefsky's diene to selectively form an exo-nitro adduct has been developed as the key step in the construction of the C-ring of the target molecule. In the Michael addition approach, the key step was a conjugate addition of an organic zinc-cuprate to the 3,4-methylenedioxy-(B-nitrostyrene, followed by a diastereocontroUed closure to form the cyclohexane C-ring of the target molecule via an intramolecular nitro-aldol cyclization on a neutral alumina surface. A chair-like transition state for such a cyclization has been established and such a chelation controlled transition state can be useful in the prediction of diastereoselectivity in other related 6-exo-trig nitroaldol reactions. Cyclization of the above products fi^om both approaches by using a Bischler-Napieralski type reaction afforded two lycoricidine derivatives 38 and 50 in good yields. The initial results from the above modeling studies as well as the analysis of the synthetic strategy were directed to a chiral pool approach to the total synthesis of optically active 7-deoxy-pancratistatin. Selective monsilylation and iodination of Ltartaric acid provided a chiral precursor for the proposed key Michael transformation. The outlook for the total synthesis of 7-deoxy-pancratistatin by this approach is very promising.A concise synthesis of novel designed, optically pure, Cz-symmetrical disulfonylamide chiral ligands starting from L-tartaric acid has also been achieved. This sequence employs the metallation of indole followed by Sfj2 replacement of a dimesylate as the key step. The activity for this Cz-symmetric chiral disulfonamide ligand in the catalytic enantioselective reaction has been confirmed by nucleophilic addition to benzaldehyde in the disulfonamide-Ti (0-i-Pr)4-diethylzinc system with a 48% yield and a 33% e.e. value. Such a ligand tethered with a suitable metal complex should be also applicable towards the total synthesis of 7-deoxy-pancratistatin.

Michael Hogue fonds

Michael H. [Henry] Hogue (1878-1963) was the son of Lemuel and Frances Hogue of Wainfleet Township, Welland County. In 1901 Michael Hogue was married to Margaret Case and they had five sons, William, Lemuel, Harry, Ross and Frank. In the 1911 Census of Canada he is residing in Welland and working as a blacksmith for Howard H. Lymburner. At Lymburner’s retirement, Hogue purchased the business and moved it from 15 Niagara Street, Welland to 12 Frazer Street, Welland. Mr. Hogue’s blacksmith activities included work with various industries in Welland including the expansion of blacksmithing work into the automobile industry. Mr. Hogue also worked for subcontractors Canadian Dredge & Dock and G.L. Campbell. These jobs included work related to the Welland Ship Canal in 1923. The business ceased operation in 1956.

Welland Canal Survey of Lands Michael and Jacob Silverthorn, 1834

Survey map and description of Michael and Jacob Silverthorn's land created by The Welland Canal Company. Included is a written description of the land along with a drawing of the land. Noteable features include; line between Burger and Silverthorn's land, reservoir, wood land, road leading to Quaker settlement, line between Jacob and Michael Silverthorn's land. The deeds for both lands are dated September 25, 1834. Surveyor notes are seen in pencil on the map.

Michael Hornyansky Fonds,

Michael Sands Hornyansky was the son of well-known artist, Nicholas Hornyansky and a cellist. He attended Oakwood Collegiate, Toronto; University College in Toronto and Merton College, Oxford where he was a Rhodes scholar. He won the Newdigate prize for poetry in 1951. Dr. Hornyansky taught English Language and Literature at Carleton University, Ottawa for 10 years before moving to Niagara in 1964. He was the founding chairman of the English Department of Brock University where he remained until his retirement in 1993. Some of his achievements include:The Golden Phoenix, a retelling of French Canadian folk tales and the publishing of papers on children’s literature and the discriminating use of the English language. He also reviewed poetry for the University of Toronto Quarterly. Michael Hornyansky died on May 14th, 2008 in Alberta at the age of 81. The annual Michael Hornyansky prize for creative writing was established at Brock University.

Photograph - Mr. & Mrs. Michael Henry (nee Almedie Mann)

A photograph of Mr. & Mrs. Michael Henry (nee. Almedie Mann) taken by G.F. Maitland, photographer, St. Paul Street, St. Catharines.

Letter- Michael H. Wilson to Donald Ziraldo, 1993

A letter from Michael H. Wilson, Minister of Industry, Science and Technology and Minister of International Trade, dated 7 May, 1993. He discusses the achievements of Inniskillin in the "Vinitaly" wine exhibition. Wilson also remarks on the great accomplishments of Mr. Ziraldo as chairman of the Ontario Vintners Quality Alliance (VQA).

Letter - Michael D. Harris to Donald Ziraldo, 2000

A letter from Premier Mike Harris to Donald Ziraldo 15 June, 2000. The correspondence discusses the possibility of agricultural preserve in Niagara.

Letter - R.Michael Mondavi to Donald Ziraldo, 1997

A letter from R. Michael Mondavi of Robert Mondavi Winery congratulating Donald Ziraldo on the release of his book Anatomy of a Winery and thanking him for the copy he was sent. He comments on the beautiful images and compares the beauty of the photographs with the landscape of Napa Valley. 2 May, 1997

Photograph - Donald Ziraldo, Michael Budman, Ross Rebagliati & others in Aspen, CO

A photograph of five people, some are identifiable, such as Donald Ziraldo, Roots Co-founder Michael Budman and Ross Rebagliati, Canadian professional snowboarder and Olympic gold medal winner for Men's Snowboarding at the 1998 Winter Olympics. On the back it is noted that this is Aspen Colorado in 1998. This may relate to the 1998 Winter Games as two people in the picture are wearing the Roots hat designed for that event.

Synthesis of a 7-Membered Biaryl Guanidine Catalyst and its Use in the Vinylogous Aldol Reaction

The present thesis outlines the preparation of a 7-membered guanidine. Initial efforts to obtain this guanidine via 2-chloro-1,3-dimethylimidazolinium chloride induced ring forming chemistry failed to provide the target in a reproducible fashion. Changing strategies, we were able to obtain the desired guanidine through CuCl mediated amination of a 7-membered thiourea intermediate to arrive at the target. In addition, the catalytic activity of this compound was evaluated in a vinylogous aldol reaction of dibromofuranone and four aromatic aldehydes to generate chiral γ-butenolides with modest to good enantiomeric excess. It was found that electron-poor aldehydes resulted in higher, 81% ee, whereas electron rich aldehydes led to low, 41% ee, levels of enantiomeric excess.

DFT Studies of the Organocatalytic Aldol Reaction and a Frustrated Lewis Pair

The computational study, and in particular the density functional theory (DFT) study of the organocatalytic α-chlorination-aldol reaction and the chiral backbone Frustrated Lewis Pair (FLP) system served as a valuable tool for experimental purposes. This thesis describes methods to consider different transition states of the proline- catalyzed α-chlorination aldol reaction to determine the reasonable transition state in the reaction between the enamine and α-chloro aldehydes. Moreover, the novel intramolecular Frustrated Lewis pair based on a chiral backbone for the asymmetric hydrogenation of imines and enamines was designed and the ability of hydrogen splitting by this new FLP system was examined by computational modeling and calculating the hydrogen activation energy barrier.

Letter to Henry Nelles from Michael Harris of the Perth Military Settlement

Letter to Henry Nelles from Michael Harris of the Perth Military Settlement (3 pages, handwritten). He is married to Mary Fanning, sister of Henry Nelles but is having marital troubles as he says he “may have to be on the lookout for another wife”. He thinks that his wife Mary may have departed for the United States, Apr. 6, 1821.