3 resultados para Glycogen accumulating organism (gao)

em Brock University, Canada


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The pyruvate dehydrogenase (PDH) complex regulates the oxidation of carbohydrates in mammals. Decreased activation of PDH following exhaustive exercise may aid the resynthesis of glycogen through increased activity of PDH kinase-4 (PDK4), one of four kinases that decrease the activity of the PDH complex. The purpose of this study was to examine the role of PDK4 in post-exercise glycogen resynthesis. Wild-type (WT) and PDK4-knockout (PDK4-KO mice) were exercised to exhaustion and were sampled at rest (Rest), at exercise exhaustion (Exh), and after two-hours post-exercise (Rec). Differences in feeding post-exercise led to the addition of a PDK4-KO group, pair-fed (PF) with WT mice. Glycogen fully recovered in all Rec groups in muscle however remained low in the PF group in liver. Flux through PDH was elevated in PDK4-KO muscle with feeding and low in the PF group in both tissues. This suggests PDK4 may fine-tune flux through PDH during exercise recovery.

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Brown sediment with clasts ranging from small to large in a sandy matrix. Clast shape ranges from angular to rounded. The clasts are mainly well dispersed. Rotation structures are common in this sample, along with grain crushing. Some lineations can also be seen in this sample.

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Brown sediment with clasts ranging from small to large. Clast shape ranges from angular to sub-rounded. The sample is dominated with a sandy matrix. Some lineations can be seen throughout the sample. Rotation structures can also be seen in minor amounts.