Esther Summers Niagara militia collection,

Butler's Rangers were disbanded in 1784. In 1788, British officials organized the Nassau Militia. Nassau was one of the Districts of Upper Canada, Niagara being only part of the district. The Nassau Militia was a military presence from 1788-1793. With the reorganization of the province into sixteen counties in 1792, Lincoln County (with 20 townships) came into existence. The militia was renamed as the Lincoln Militia. At the outbreak of the War of 1812, the Lincoln Militia was organized into five regiments. Later, members of the Lincoln Militia were called out for duty to track and subdue insurgents during the 1837 Rebellions. In 1846, Lincoln County divided into Lincoln and Welland counties, and militia regiments were reformed. This changed many times until 1936 when they became known as The Lincoln and Welland Regiment.

A Survey of hMLH1 mRNA Splicing Profiles in Human Cell Lines: Comparing Primary Cultured Fibroblasts Before and After Oxidative Stress and Transiently versus Stably Demethylated Colon Cancer Derived Cell Lines

Most human genes undergo alternative splicing and loss of splicing fidelity is associated with disease. Epigenetic silencing of hMLH 1 via promoter cytosine methylation is causally linked to a subset of sporadic non-polyposis colon cancer and is reversible by 5-aza-2' -deoxycytidine treatment. Here I investigated changes in hMLHI mRNA splicing profiles in normal fibroblasts and colon cancer-derived human cell lines. I established the types and frequencies of hMLHI mRNA transcripts generated under baseline conditions, after hydrogen peroxide induced oxidative stress, and in acutely 5-aza-2' -deoxycytidine-treated and stably derepressed cancer cell lines. I found that hMLHI is extensively spliced under all conditions including baseline (50% splice variants), the splice variant distribution changes in response to oxidative stress, and certain splice variants are sensitive to 5- aza-2' -deoxycytidine treatment: Splice variant diversity and frequency of exon 17 skipping correlates with the level of hMLHI promoter methylation suggesting a link between promoter methylation and mRNA splicing.

Oliver Rising Sr. Diary, 1797-1851

Oliver Rising (1775-1855) lived in Herkimer County, New York. He is buried in Cedar Lake Cemetery, Cedar Lake (part of the town of Litchfield) in Herkimer County, with his wife Hannah (1780-1855) and his son Oliver Rising Jr. (1817-1861).

A research capacity strengthening project for infectious diseases in Honduras: experience and lessons learned

Background: In Honduras, research capacity strengthening (RCS) has not received sufficient attention, but an increase in research competencies would enable local scientists to advance knowledge and contribute to national priorities, including the Millennium Development Goals (MDGs). Objective: This project aimed at strengthening research capacity in infectious diseases in Honduras, focusing on the School of Microbiology of the National Autonomous University of Honduras (UNAH). The primary objective was the creation of a research-based graduate program for the continued training of researchers. Parallel objectives included institutional strengthening and the facilitation of partnerships and networks. Methods: Based on a multi-stakeholder consultation, an RCS workplan was designed and undertaken from 2007 to 2012. Due to unexpected adverse circumstances, the first 2 years were heavily dedicated to implementing the project's flagship, an MSc program in infectious and zoonotic diseases (MEIZ). In addition, infrastructure improvements and demand-driven continuing education opportunities were facilitated; biosafety and research ethics knowledge and practices were enhanced, and networks fostering collaborative work were created or expanded. Results: The project coincided with the peak of UNAH's radical administrative reform and an unprecedented constitutional crisis. Challenges notwithstanding, in September 2009, MEIZ admitted the first cohort of students, all of whom undertook MDG-related projects graduating successfully by 2012. Importantly, MEIZ has been helpful in expanding the School of Microbiology's traditional etiology-based, disciplinary model to infectious disease teaching and research. By fulfilling its objectives, the project contributed to a stronger research culture upholding safety and ethical values at the university. Conclusions: The resources and strategic vision afforded by the project enhanced UNAH's overall research capacity and its potential contribution to the MDGs. Furthermore, increased research activity and the ensuing improvement in performance indicators at the prime Honduran research institution invoke the need for a national research system in Honduras.

Diary of Oliver Rising Senior,1797-1851

A diary and account book of Oliver Rising Senior, of Herkimer County, New York. The diary includes a black and white photograph of Esther Rising Myers and one of Rev. John Myers pasted onto the pages. Oliver recounts his travels into Canada through Chippawa, Niagara Falls, and the garrison at Little York in 1797 (p. 61-62). He also describes the British invasion of Sacket’s Harbour in 1812 (p. 100).