Letter from George W. Campbell, esq., late Secretary of the Treasury, to the Chairman of the Committee appointed to inquire into the causes and particulars of the invasion of the City of Washington, and the neighboring town of Alexandria, in the month of August last. --

Laid before the House by the Chairman of the said Committee, and ordered to be printed January 2, 1815.

Probate of the Last Will and Testament of Joseph Clement

Probate of the Last Will and Testament of Joseph Clement of the Township of Niagara, May 14, 1810 but it is noted that this is a copy of the original will and this copy was filed on Feb. 26, 1815, Nov. 25, 1875. This is accompanied by an envelope addressed to Sheriff Woodruff and postmarked Hamilton, Nov. 25, 1875.

Letter from George W. Campbell the Chairman of the Committee appointed to inquire into the causes and particulars of the invasion of the City of Washington

Full Title: Letter from George W. Campbell, esq., late Secretary of the Treasury, to the Chairman of the Committee appointed to inquire into the causes and particulars of the invasion of the City of Washington, and the neighboring town of Alexandria, in the month of August last Laid before the House by the Chairman of the said Committee, and ordered to be printed January 2, 1815. 13th Congress, 3rd Session. House. Doc. 38. Printed by Roger C. Weightman

Indenture Land Sold by Thomas Clark to Lewis Clement, 1817

Indenture regarding land sold by Thomas Clark of Stamford Township to Lewis Clement of Niagara Township. The land includes 50 acres in the northern half of Lot 58 in Niagara Township - instrument no. 5356, January 17, 1817.

Indenture between John Baptist Clement and William Woodruff

Indenture of bargain and sale between John Baptist Clement of Niagara and William Woodruff of St. Davids for part of Lot no. 90 in St. Davids. Instrument no. 9050, February 23, 1833.

Niagara churches collection, 1937, 1968-1994

This collection contains 7 church programs and brochures, ranging in date from 1937 to 1994. There are programs for church services at Knox Presbyterian Church, St. Catharines (May 9, 1937); St. Catherine of Alexandria Cathedral, St. Catharines (July 28, 1968) ; Memorial United Church, Ridgeway (October 15, 1972); Salem Chapel, British Methodist Episcopal Church, St. Catharines (November 30, 1986); and Ridley College Memorial Chapel, St. Catharines (December 3 & 4, 1994). There is also a brochure of activities offered at St. Paul Street United Church, St. Catharines (1986), and a development fund appeal brochure for the Cathedral of St. Catherine, St. Catharines (1985).

Indenture between Jacob Canniff and Susan Canniff

Indenture (vellum) of bargain and sale between Jacob Canniff and Susan Canniff of Niagara to Lewis Clement of Niagara, the south half of Lot 69 Town of Niagara - Instrument no. 7072, June 21, 1827.

Family Record of the Clement Family

Family Record of the Clement Family (1 printed page) listing Clement family members born from 1750 – 1808, n.d.

Family Record of the Clement Family (on fabric)

Family Record of the Clement Family (1 printed page) exactly as above, but printed on fabric, n.d.

Statement signed by Hume Blake who has read the will of Joseph Clement and the will of Mary M. Clement

Statement signed by Hume Blake of Toronto (2 ½ pages) who has read the will of Joseph Clement dated May 14, 1810 and has also read the will of Mary M. Clement dated Sept. 10, 1842. He states that the devise to James D. Clement and Joseph Clement is void. “The executor therefore take the personal estate … and the lands devised to James and Joseph Clement descend unencumbered to the heir of the testator Joseph Clement.” This document is slightly burned on the edges but text is not affected. The outer page says “Mr. Hume Blake for Brock Woodruff, May 9, 1845.

Estimate of work done by Alexander Cook, Andrew Mains, Frederick Holmes, Louis Clement, Patrick Roche and Thomas Baird

Estimate of work done by Alexander Cook, Andrew Mains, Frederick Holmes, Louis Clement, Patrick Roche and Thomas Baird, signed by S.D. Woodruff, Feb. 26, 1855.

Engineer services in the marsh lands drainage to the 28th of April inclusive to Frederick Holmes, Louis Clement and Thomas Baird

Engineer services in the marsh lands drainage to the 28th of April inclusive to Frederick Holmes, Louis Clement and Thomas Baird. Signed by S.D. Woodruff, April 28, 1855.

Amplification of the DFR1 gene in Saccaromyces cerevisiae

A new system was employed to study amplification of t,he DHF'R gene DFB,1 ) in Sa<,:;charoillYCB§. .Q~~Yi...S!i<;1~. . This system consists of a series of yeast strains containing a casset,te which encodes t he yeast, D..ERl gene ttghtly linked tjO a f usion of the yeast 1EU2. regulat,ory region wi tJ1 the LAQZ str ctural gene from E. cO.1-1 (,) . M. Clement , unpubl i,::;hed) . Th's casset;t e was shown t.o be integrat,ed int o a unj que chromosomal l ocati on in each strain . Yeast cells were se l ected for MTX-resistance and overproduction of ~ galac t osi d se ( B-gal ). Since the inserted DF'Rl and ~ACZ genes are independently regulated, it was thought that cel l s with this phenotype probably contain e d ampl if ications of the cassette. A lar ge variat ion in the f requn y o f MTX-resistance was found between the di ff e r ent str ains. These freqlen c ~ es r anged from about 2 x 10 - 7 fo r a population of cells containing the cassette integrated at, the BI J2.l gene in t,he middle of the long arm of chromosome V, to about 5 x 10-4 for a strain with the cassette i nserted in the r DNA cluster Abo It 85% of the MTX- res i stcmt iso l ates examined showed enhanced B·-gal act i v ity rel a t ive t o the parental strain . For the ma jorit y of strains, the mean B- gal activity in drug-r sistant clones was about 3 times that o f the parent following a single se l ect i on step . I n con t r ast, primary MTX-resistant derivat~ves of cells with the cassette inserted 3 at the rDNA cluster showed inc r eases in B- gal activity ranging from 9 - 14 f old r elative to the parent. Analysis of the latte r s train by Southe rn hybr idization indicated that the cassette was inde e d amplified several fold in MTX-re sistant derivatives. A sing l e strain, in which the cassette was inserted at the !lEA;], loc u.s , was used to examine in more detai 1 , the parameters affecting DFRl gene amplificat~ion in yeast . The mean B- gal activity in drug-resistant derivatives of this strain could be increased from 3 to 6 or 7 fold relative to the parent, by stepwise sel ection using increasing MTX concentrations. B-gal overproduction was found to be un stable in all primary and highly -resistant isolates examined. There was no indication, h owever, of a decrease i n growth r a t e in MTX-res i s tant cells which overproduced B - gal.

An Address of members of the House of Representatives of the Congress of the United States, to their constituents, on the subject of the war with Great Britain. --

Signed by George Sullivan and thirty-three other Federalist members.