William B. Rollason fonds, 1930-1934, 1936, 1941-1947, 1950-1952, 1956-1958.

William B. Rollason was a businessman from St. Catharines. His business interests included insurance sales, real estate and housing development. He was an active Rotarian, serving as president from 1945 to 1946. He served on the Niagara Parks Commission Board from 1944 until his death in 1959. Mr. Rollason was the president of the St. Catharines Chamber of Commerce, president of the Lincoln County Conservative Association, a member of the Navy Island Peace Capital Group, vice chairman of the War Savings Committee and part owner of the Welland House Hotel in St. Catharines.

Identification of renin progenitors in the mouse bone marrow that give rise to B-cell leukaemia

cell of origin and triggering events for leukaemia are mostly unknown. Here we show that the bone marrow contains a progenitor that expresses renin throughout development and possesses a B-lymphocyte pedigree. This cell requires RBP-J to differentiate. Deletion of RBP-J in these renin-expressing progenitors enriches the precursor B-cell gene programme and constrains lymphocyte differentiation, facilitated by H3K4me3 activating marks in genes that control the pre-B stage. Mutant cells undergo neoplastic transformation, and mice develop a highly penetrant B-cell leukaemia with multi-organ infiltration and early death. These reninexpressing cells appear uniquely vulnerable as other conditional models of RBP-J deletion do not result in leukaemia. The discovery of these unique renin progenitors in the bone marrow and the model of leukaemia described herein may enhance our understanding of normal and neoplastic haematopoiesis.

HG 244.40-244.55-B Thin Section

Coarse grained sample with sub-angular to sub-rounded clasts ranging from small-large in size. Rotation structures, grain crushing and lineations were seen throughout the sample.

Indenture between Joseph Jackson and William Woodruff (B)

Indenture of bargain and sale between Joseph Jackson of Buffalo, New York and William Woodruff of St. Davids regarding Lot no. 90 in Niagara Township. This was registered in the County of Lincoln on April 30, 1842 in Book B, folio 299. The instrument no. is 732. It was written 17 March 1842.

Indenture between William and Ann Waters and William B. Winterbottom

Indenture of mortgage with dower between William and Ann Waters of Niagara to William B. Winterbottom of Niagara regarding the easterly half of Lot no. 265 in Niagara. This was recorded in the Register of Forms of Niagara on April 13, 1850, Book A, folios 207-208 - instrument no. 2093, April 1, 1850.

Letter to S.D. Woodruff from J.J.B. in Saginaw, Michigan.

Letter (1 handwritten, double sided page) to S.D. Woodruff from J.J.B. in Saginaw, Michigan. J.J.B. says that he doesn’t want any money for his information. He explains where the pine is, and encloses a crudely drawn map. He says the Mr. Woodruff can correspond with him, but to please keep this a secret, Jan. 23, 1880.

Receipt from B. Davis, Toronto for ice bowl

Receipt from D. Davis, Toronto for ice bowl, July 2, 1887.

Letter to Henry Nelles from S.B. Ritchie

Letter to Henry Nelles from S.B. Ritchie (1 page, double-sided) wondering what the prospects for the Welland Canal will be in the next season. This letter is somewhat stained. This does not affect the text. This is accompanied by an envelope, Feb. 3, 1834.

Letter to J. Bradley from B.C.A. Gogy

Letter to J. Bradley from B.C.A. Gogy in the Office of the Adjutant General of Militia, Montreal (1 page, printed) regarding Bradley’s desire to obtain commission as a captain in the Quebec Artillery, Aug. 25, 1845

Letter to J.P. Bradley from B.C.A. Gogy

Letter to J.P. Bradley from B.C.A. Gogy in the Office of the Adjutant General of Militia, Montreal regarding procedures for applying for a captain’s commission in the militia (2 ½ pages, handwritten), Dec. 23, 1845.

Appointment of John B. Parkynn [Parkin] (J.P. Bradley’s brother) to be an Ensign of the 1st Company of the Royal Quebec Volunteers

Appointment of John B. Parkynn [Parkin] (J.P. Bradley’s brother) to be an Ensign of the 1st Company of the Royal Quebec Volunteers. This is signed by the Governor General, the Earl of Gosford and Governor General, Secretary J. Walcott, Nov. 27, 1837.