Predicting the Risk of Lung Cancer in Never-smokers

Despite being considered a disease of smokers, approximately 10-15% of lung cancer cases occur in never-smokers. Lung cancer risk prediction models have demonstrated excellent ability to discriminate cases from non-cases, and have been shown to be more efficient at selecting individuals for future screening than current criteria. Existing models have primarily been developed in populations of smokers, thus there was a need to develop an accurate model in never-smokers. This study focused on developing and validating a model using never-smokers from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Cox regression analysis, with six-year follow-up, was used for model building. Predictors included: age, body mass index, education level, personal history of cancer, family history of lung cancer, previous chest X-ray, and secondhand smoke exposure. This model achieved fair discrimination (optimism corrected c-statistic = 0.6645) and good calibration. This represents an improvement on existing neversmoker models, but is not suitable for individual-level risk prediction.

Letter to S.D. Woodruff

Letter which is postmarked Buffalo, April 15 and Queenston, April 15 and is addressed to S.D. Woodruff. This letter instructs Mr. Woodruff to send his fees in care of Thompson and Co. The signature is illegible, April 13, 1846.

History of the Late War between Great Britain and the United States of America

History of the Late War between Great Britain and the United States of America by David Thompson, late of the Royal Scots, Niagara U.C. , 1832. There is an inscription in the front of the book which says “[illegible] Nelles, Grimsby and it is signed by Joseph Williams [?]” The book is stained from dampness, but this does not affect the text, 1832.

Identifying, Engaging, and Supporting 21st Century Reluctant Readers

Reading is becoming nearly inseparable from life in the 21st century. Moore, Bean, Birdyshaw, and Rycik (1999) suggest that “adolescents entering the adult world in the 21st century will read and write printed text or alphabetical text more than at any other time in human history” (p. 99). However, engaging with text and reading activities is unappealing to many students in today’s classrooms. This major research paper analyzed contemporary research on reading reluctance and the factors that contribute to this reluctance. Additionally, the study examined previous research to better understand the characteristics of students reluctant to read in grades 4-6. This information has provided the foundation for a handbook designed to help educators identify and engage students who experience a reluctance to read.