Cell-selective modulation of the neuromuscular system in Drosophila

The capacity for all living cells to sense and interact with their environment is a necessity for life. In highly evolved, eukaryotic species, like humans, signalling mechanisms are necessary to regulate the function and survival of all cells in the organism. Synchronizing systemic signalling systems at the cellular, organ and whole-organism level is a formidable task, and for most species requires a large number of signalling molecules and their receptors. One of the major types of signalling molecules used throughout the animal kingdom are modulatory substances (e.x. hormones and peptides). Modulators can act as chemical transmitters, facilitating communication at chemical synapses. There are hundreds of circulating modulators within the mammalian system, but the reason for so many remains a mystery. Recent work with the fruit fly, Drosophila melanogaster demonstrated the capacity for peptides to modulate synaptic transmission in a neuron-specific manner, suggesting that peptides are not simply redundant, but rather may have highly specific roles. Thus, the diversity of peptides may reflect cell-specific functions. The main objective of my doctoral thesis was to examine the extent to which neuromodulator substances and their receptors modulate synaptic transmission at a cell-specific level using D. melanogaster. Using three different modulatory substances, i) octopamine - a biogenic amine released from motor neuron terminals, ii) DPKQDFMRFa - a neuropeptide secreted into circulation, and iii) Proctolin - a pentapeptide released both from motor neuron terminals and into circulation, I was able to investigate not only the capacity of these various substances to work in a cell-selective manner, but also examine the different mechanisms of action and how modulatory substances work in concert to execute systemic functionality . The results support the idea that modulatory substances act in a circuit-selective manner in the central nervous system and in the periphery in order to coordinate and synchronize physiologically and behaviourally relevant outputs. The findings contribute as to why the nervous system encodes so many modulatory substances.

Accounting for Human Rights Violations Risk: Conflict Minerals Mandatory Disclosures under the Dodd Frank Act

This paper examines the equity market response to firms’ disclosure of human rights violation risk with regard to conflict mineral usage as required by Section 1502 of the Dodd-Frank Act (the Act). This paper assesses the aggregate equity market response to regulatory events leading to the passage of the Act, the equity market reaction to voluntary early disclosures and mandatory disclosures of conflict mineral information in Form SD, as well as the determinants of the equity market response. Using a sample of 4,399 US registrants from January 1, 2008 to September 30, 2014, we document a significant negative stock market reaction to the passage of the Act and to conflict minerals disclosures on Form SD. The equity market reaction is more negative and limited to companies that source their minerals from conflict zones, companies with human rights violations, and companies with ambiguous disclosures. Taken together, the results of this study provide an economic justification for companies with poor conflict minerals practices to improve in order to avoid high costs that will arise if firms are forced to disclose human rights abuses. This paper also provides preliminary evidence that Form SD is successful in reducing the governance gap that exposes investors to unnecessary sanction, litigation and reputation risk from firms’ activities in conflict minerals usage.

Certificate for Six Shares of Capital Stock in Gove Motor Car Company, Detroit, Michigcan

Certificate for 6 shares of common capital stock in Gove Motor Car Company, Detroit, Michigan to Hamilton K. Woodruff, June 13, 1921.

Certificate for Two Shares of Preferred Capital Stock in Gove Motor Car Company, Detroit, Michigan

Certificate for 2 shares of preferred capital stock in Gove Motor Car Company, Detroit, Michigan to Hamilton K. Woodruff, June 13, 1921.

Printed Blank Regarding the Insolvent Act of 1864 from James McWhirter to S.D. Woodruff

Printed blank regarding the Insolvent Act of 1864, this was sent to S. D. Woodruff in the matter of William Little, an insolvent. There was to be a meeting on the 10th day of October for public examination of the insolvent. The document was signed by James McWhirter, official assignee, Sept. 20, 1866.

Act to incorporate the Long Point Company

Act to incorporate the Long Point Company. This is a 4 page document, printed on vellum. It was printed by Malcolm Cameron, Law Printer to the Queen, Aug. 15, 1866.

An act to consolidate and amend the laws for protection of game and fur-bearing animals in Ontario

An act to consolidate and amend the laws for protection of game and fur-bearing animals in Ontario (1 double-sided page of printed material), 1871.

Amendment to the Act of Incorporation, chapter 122 of the Long Point Company

Amendment to the Act of Incorporation, chapter 122 of the Long Point Company. This is put out by John I. Mackenzie, secretary, treasurer (2 printed pages), Feb. 18, 1885.

Bill no. 2: An act to amend an act entitled “An Act to Incorporate the Long Point Company”

Bill no. 2: An act to amend an act entitled “An Act to Incorporate the Long Point Company” (1 printed page), 1885.

Bill no. 20: An act to amend the acts relating to the Long Point Company

Bill no. 20: An act to amend the acts relating to the Long Point Company (2 ¼ printed pages), 1887.

Bill no.71: An act respecting the Public Works of Ontario

Bill no.71: An act respecting the Public Works of Ontario (10 ½ pages, printed). S.D. Woodruff has signed this copy of the bill and has made a note in pension “regulations for management”, 1868.