49 resultados para Emory and Henry College
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Crick, Henry A., includes Application for Loan, Jan. 8, 1885 and Mortgage Loan Envelope no. 637 for Jan. 1, 1885 – Jan. 1, 1890.
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The exact mechanistic understanding of various organocatalytic systems in asymmetric reactions such as Henry and aza-Henry transformations is important for developing and designing new synthetic organocatalysts. The focus of this dissertation will be on the use of density functional theory (DFT) for studying the asymmetric aza-Henry reaction. The first part of the thesis is a detailed mechanistic investigation of a poorly understood chiral bis(amidine) (BAM) Brønsted acid catalyzed aza-Henry reaction between nitromethane and N-Boc phenylaldimine. The catalyst, in addition to acting as a Brønsted base, serves to simultaneously activate both the electrophile and the nucleophile through dual H-bonding during C-C bond formation and is thus essential for both reaction rate and selectivity. Analysis of the H-bonding interactions revealed that there was a strong preference for the formation of a homonuclear positive charge-assisted H-bond, which in turn governed the relative orientation of substrate binding. Attracted by this well-defined mechanistic investigation, the other important aspect of my PhD research addressed a detailed theoretical analysis accounting for the observed selectivity in diastereoselective versions of this reaction. A detailed inspection of the stereodetermining C-C bond forming transition states for monoalkylated nitronate addition to a range of electronically different aldimines, revealed that the origins of stereoselectivity were controlled by a delicate balance of different factors such as steric, orbital interactions, and the extent of distortion in the catalyst and substrates. The structural analysis of different substituted transition states established an interesting dependency on matching the shape and size of the catalyst (host molecule) and substrates (guest molecules) upon binding, both being key factors governing selectivity, in essence, offering an analogy to positive cooperative binding effect of catalytic enzymes and substrates in Nature. In addition, both intra-molecular (intra-host) and inter-molecular (host-guest, guest-guest) stabilizing interactions play a key role to the high π-facial selectivity. The application of dispersion-corrected functionals (i.e., ωB97X-D and B3LYP-D3) was essential for accurately modeling these stabilizing interactions, indicating the importance of dispersion effects in enantioselectivity. As a brief prelude to more extensive future studies, the influence of a triflate counterion on both reactivity and selectivity in this reaction was also addressed.
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Time on marsh lands for the months of January, February, March and April for Fred Holmes, Joseph Simpson, Duncan Davidson, Rose Osborne, Henry Wilson and William Baird. This is signed by Fred Holmes, April 28, 1857.
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Engineering services in marsh lands drainage for the months of January, February, March and April for Fred Holmes, Joseph Simpson, D. Davidson, Rose Osborne, Henry Wilson and William Baird. This is signed by S.D. Woodruff, May 1, 1857.
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Indenture of bargain and sale between Henry and Mary Miller of the Town of Niagara to Joseph Augustus Woodruff of the Town of Niagara for 50 acres in the east half of Lot no. 15 in the 1st Concession in the Township of Southwold in Elgin County, April 2, 1853.
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Receipt from Henry Carlisle, Importer of Dry Goods and Millinery, St. Catharines for hats, Dec. 31, 1886.
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Receipt from Henry O’Laughlin, dealer in Anthracite and Bituminous Coals, St. Catharines for payment on account, Nov. 15, 1887.
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Letter to Henry Nelles from Montreal merchants Gillespie and Moffatt (1 ½ pages, handwritten) regarding supplies from Europe. This letter is quite stained and torn. This does affect a good portion of the text, Oct. 11, 1824.
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Letter to Henry Nelles from Gillespie and Moffatt regarding the rising costs of goods, especially flour, Oct. 3, 1828.
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Letter to Henry Nelles from Gillespie and Moffat (3 pages, handwritten) regarding wheat and an account of flour consigned to J. McPerson, Feb. 26, 1829.
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Letter to Henry Nelles from Gillespie and Moffatt (2 pages) regarding the price of wheat, Oct. 19 (1 double-sided page, handwritten), 1829.
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Letter (copy) in three sections (1 ½ pages, handwritten). The first part is addressed to Henry Nelles from M. Douglass in which Mr. Douglass says he has enclosed $50. This section is dated Feb. 8, 1830. The second part is also addressed to Henry Nelles and is signed Mr. D. This is the section that says “your letter has just come stating that you had received a letter but the $50 was not in the letter. There was $50 in it when it left this post office. This is dated Feb. 14, 1830. The third part is addressed to Mr. Griffen from George M. Richardson. It says that this is to certify that Mr. Douglass did mail $50 on the 18th of this month. This letter is stained and slightly torn. Some of the text is affected. [This letter has to do with the case about the missing money which is included in this collection], Feb. 8, 1830.
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List of goods shipped to Henry Nelles of Grimsby by Gerrard, Gillespie and Moffat Co. of Montreal (6 ½ page list, handwritten) for blankets, food, clothing and other items Sept. 14, 1821.
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Appointment of Phyn Ellices and Inglis to be the lawful attorneys of Henry W. Nelles, June 20, 1788.
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Questions put to, and answered by Henry Nelles (1 double-sided page, handwritten). The pages are stained and contain some holes. This affects the text slightly, 1830.