Last will and testament - Peter Wright

The last will and testament of Peter Wright, dated December 18th, 1812. He was the father of Mary Wright, the first wife of Thomas Wilson (third generation). In the will, Peter states his executors as Lawrence Lemon, George Garner, and his wife Susannah Wright. There is also a transcript of the handwritten will.

Thomas Young reward claim, October 30, 1875

Transcript: Sir I understand that a reward of fifty dollars has been offered by the County of Haldimand for the arrest of any person convicted of horse stealing. I beg to state that I arrested Albert Hucker charged with having stolen a bay mare the property of Eward Hodges in the Township of Walpole Co. of Haldimand and that the said Albert Hucker has been convicted of the offence by A.G. Hill, Esq. police magistrate of the Town of Clifton County of Welland, and sentenced to three years servitude in the provincial penitentiary. I beg therefore to ask of I am entitled to the aforesaid reward and if so what steps are necessary to procure it. I am Sir, Yours respectfully, Thomas H. Young Ontario Police Clifton

Preliminary characterization of VmTPT2, a putative monoterpene indole alkaloid (MIA) transporter from Vinca minor L. (Apocynaceae)

The various steps of monoterpene indole alkaloid (MIA) biosynthesis are known to occur in specialized cell types and subcellular compartments. Numerous MIAs display powerful biological activities that have led to their use as pharmaceutical treatments for cancer, hypertension and malaria. Many of these compounds accumulate on the leaf surface of medicinally important Apocynaceae plants, which led to the recent discovery and characterization of an ABC transporter (CrTPT2) that was shown to mobilize catharanthine from its site of biosynthesis in epidermal cells to the leaf surface of Catharanthus roseus. Bioinformatic analysis of transcriptomes from several geographically distant MIA-producing species led to the identification of proteins with high amino acid sequence identity to CrTPT2. Molecular cloning of a similar transporter (VmTPT2) from Vinca minor was carried out and expressed in a yeast heterologous system for transport experiments and functional characterization. In planta studies involved transcript expression analysis of the early MIA biosynthetic gene VmTDC and putative transporter VmTPT2, and alkaloid profile analyses. RT-qPCR results showed that VmTPT2 expression increased 15-fold between the first two leaf pairs, and high levels were maintained across older leaves. The alkaloid accumulation profile on leaf surfaces matched that of VmTPT2 expression, especially for the MIAs vincadifformine and vincamine. Gene expression and alkaloid profile analyses suggest that the functional protein may act as a similar transporter to CrTPT2. However, although VmTPT2 had 88.4% identity at the amino acid level to CrTPT2, it displayed an altered expression pattern in planta across developing leaves, and functional characterization using a previously developed yeast heterologous system was unsuccessful due to difficulties with reproducibility of transport assays.

Letter to David Therburn [Thorburn] from W. Woodruff

Letter outlining the firsthand account of the Battle of Queenston Heights describing the day that General Brock was killed [a copy of this letter (taken from Mr. Thorburn’s files) has been published in the book The Story of Laura Secord and Canadian Reminiscences by Emma A. Currie and it is also printed in History of the Campaign upon the Niagara Frontier in the year 1812 by Lieutenant Colonel E. Cruikshank] (7 handwritten pages) written by W. Woodruff and addressed to David Therburn [Thorburn] of Queenston. There are 3 handwritten copies of this account. A transcript of this letter has been included in the file, July 29, 1840.

Letter to the Editor of the Globe

Letter Regarding the Burning of St. Davids (3 ½ handwritten pages) A letter to the editor of the Globe regarding the lack of historical knowledge displayed by the Globe’s correspondent regarding the descendants of those who fought at Queenston Heights and the burning of St. Davids in 1813 or 1814 [July 18, 1814]. The letter also mentions the “friendly Indians” who encamped in St. Davids. The letter is not signed nor dated. A transcript of the letter is enclosed, [The burning of St. Davids by the American troops on July 19, 1814 was an unjustifiable act. The officer who led the attack was court-martialed and dismissed from the service.] n.d.