The road to peace, commerce, wealth, and happiness /

Attributed to John Lowell. Cf. NUC pre-1956 imprints.

The road to peace, commerce, wealth, and happiness

Attributed to John Lowell. Cf. NUC pre-1956 imprints. Caption title. Shaw and Shoemaker

Toward Peace - Spring Concert St. Catharines Public Schools Programme, 1945

A spring concert programme by the St. Catharines Public Schools on May 4, 1945. The concert is titled "Toward Peace" and features the students of the following schools: Alexandra, Cavell, Central, Connaught, Memorial, Robertson, Victoria, Court St., Prince of Wales, St. Andrew's Ward, Glen Ridge, St. Paul's Ward, Queen Elizabeth.

Myosin Regulatory Light Chain Phosphorylation and Its Effect on the Contractile Economy of Mouse Fast Muscle

Activated by elevations in myoplasmic calcium concentration, myosin light chain kinase (skMLCK) phosphorylates the regulatory light chains (RLCs) of fast muscle myosin. This covalent modification potentiates force production, but requires an investment of ATP. Our objective was to investigate the effect of RLC phosphorylation on the contractile economy (mechanical output:metabolic input) of fast twitch skeletal muscle. Extensor digitorum longus muscles isolated from Wildtype and skMLCK-/- mice mounted in vitro (25°C) were subjected to repetitive low-frequency stimulation (10Hz,15s) known to cause activation of skMLCK, and staircase potentiation of force. With a 3-fold increase in RLC phosphate content, Wildtype generated 44% more force than skMLCK-/- muscles over the stimulation period (P = .002), without an accompanied increase in energy cost (P = .449). Overall, the contractile economy of Wildtype muscles, with an intact RLC phosphorylation mechanism, was 73% greater than skMLCK /- muscles (P = .043), demonstrating an important physiological function of skMLCK during repetitive contractile activity.

Indenture of deed of bargain and sale between Samuel Rock of Crowland Township and Samuel Street of the Town of Niagara

Indenture of deed of bargain and sale between Samuel Rock of Crowland Township and Samuel Street of the Town of Niagara for 1 acre in Lot no. 179 in the Town of Niagara – instrument no. 13070. A memorial of this record was made on Feb. 21, 1856, List B, Folio 169. An envelope addressed to Joseph Woodruff, Clerk of the Peace and postmarked Jan. 1857 was included with this document, July 17, 1840.