Welland Canal Survey of Lands Estate of Hall Davis and Jeremiah Adley 1834

Survey map and description of the Estate of Hall Davis and Jeremiah Adley's land created by The Welland Canal Company. Included is a written description of the land along with a drawing of the land. Noteable features include; Holland road, Adley's house, waste weir. The total land for the Estate of Hall Davis is 27 acres and 2 perches. The total land for Adley is 3 acres. The deed for the Estate of Hall Davis is dated August 16th 1834 and contains Samuel Swayze's name. Swayze's name is also written under Hall Davis' name. The deed for Adley's land is dated December 1st 1827. Surveyor notes are seen in pencil on the map.

Walker Hall - Vignette

A vignette of Walker Hall, John S. Walker, Esq. Clinton Township.

Transposable Elements Are a Significant Contributor to Tandem Repeats in the Human Genome

Sequence repeats are an important phenomenon in the human genome, playing important roles in genomic alteration often with phenotypic consequences. The two major types of repeat elements in the human genome are tandem repeats (TRs) including microsatellites, minisatellites, and satellites and transposable elements (TEs). So far, very little has been known about the relationship between these two types of repeats. In this study, we identified TRs that are derived from TEs either based on sequence similarity or overlapping genomic positions. We then analyzed the distribution of these TRs among TE families/subfamilies. Our study shows that at least 7,276 TRs or 23% of all minisatellites/satellites is derived from TEs, contributing ∼0.32% of the human genome. TRs seem to be generated more likely from younger/more active TEs, and once initiated they are expanded with time via local duplication of the repeat units. The currently postulated mechanisms for origin of TRs can explain only 6% of all TE-derived TRs, indicating the presence of one or more yet to be identified mechanisms for the initiation of such repeats. Our result suggests that TEs are contributing to genome expansion and alteration not only by transposition but also by generating tandem repeats.

HUMAN GENOME VARIATIONS AND EVOLUTION WITH A FOCUS ON THE ANALYSIS OF TRANSPOSABLE ELEMENTS

Genome sequence varies in numerous ways among individuals although the gross architecture is fixed for all humans. Retrotransposons create one of the most abundant structural variants in the human genome and are divided in many families, with certain members in some families, e.g., L1, Alu, SVA, and HERV-K, remaining active for transposition. Along with other types of genomic variants, retrotransponson-derived variants contribute to the whole spectrum of genome variants in humans. With the advancement of sequencing techniques, many human genomes are being sequenced at the individual level, fueling the comparative research on these variants among individuals. In this thesis, the evolution and functional impact of structural variations is examined primarily focusing on retrotransposons in the context of human evolution. The thesis comprises of three different studies on the topics that are presented in three data chapters. First, the recent evolution of all human specific AluYb members, representing the second most active subfamily of Alus, was tracked to identify their source/master copy using a novel approach. All human-specific AluYb elements from the reference genome were extracted, aligned with one another to construct clusters of similar copies and each cluster was analyzed to generate the evolutionary relationship between the members of the cluster. The approach resulted in identification of one major driver copy of all human specific Yb8 and the source copy of the Yb9 lineage. Three new subfamilies within the AluYb family – Yb8a1, Yb10 and Yb11 were also identified, with Yb11 being the youngest and most polymorphic. Second, an attempt to construct a relation between transposable elements (TEs) and tandem repeats (TRs) was made at a genome-wide scale for the first time. Upon sequence comparison, positional cross-checking and other relevant analyses, it was observed that over 20% of all TRs are derived from TEs. This result established the first connection between these two types of repetitive elements, and extends our appreciation for the impact of TEs on genomes. Furthermore, only 6% of these TE-derived TRs follow the already postulated initiation and expansion mechanisms, suggesting that the others are likely to follow a yet-unidentified mechanism. Third, by taking a combination of multiple computational approaches involving all types of genetic variations published so far including transposable elements, the first whole genome sequence of the most recent common ancestor of all modern human populations that diverged into different populations around 125,000-100,000 years ago was constructed. The study shows that the current reference genome sequence is 8.89 million base pairs larger than our common ancestor’s genome, contributed by a whole spectrum of genetic mechanisms. The use of this ancestral reference genome to facilitate the analysis of personal genomes was demonstrated using an example genome and more insightful recent evolutionary analyses involving the Neanderthal genome. The three data chapters presented in this thesis conclude that the tandem repeats and transposable elements are not two entirely distinctly isolated elements as over 20% TRs are actually derived from TEs. Certain subfamilies of TEs themselves are still evolving with the generation of newer subfamilies. The evolutionary analyses of all TEs along with other genomic variants helped to construct the genome sequence of the most recent common ancestor to all modern human populations which provides a better alternative to human reference genome and can be a useful resource for the study of personal genomics, population genetics, human and primate evolution.

Slide - Inniskillin Hall at Brock University

Mr. Ziraldo was instrumental in establishing the Cool Climate Oenology and Viticulture Institute (CCOVI) at Brock University which focuses on excellence in winemaking. Brock University named the building that houses CCOVI, Inniskillin Hall. The hall opened in the year 1999.

Bettelheim, Tinbergen and Hall fonds, 1972-1981

Elizabeth Hall was a managing editor of Psychology Today, who on separate occasions interviewed Oxford ethologist Nikolaas Tinbergen (1907-1988) and psychologist Bruno Bettelheim (1903-1990). Her 1973 interview with Tinbergen, conducted at his vacation home in the Cumberland region of northern England, was published later that year in Psychology Today. She left the magazine in 1976 to run the journal Human Nature, but left this position in 1979. She continued to contribute articles to various magazines, but most notably to Psychology Today. Her interview with Bruno Bettelheim appeared in that magazine in 1981.

Photograph - Samuel DeVeaux Woodruff at DeVeaux Hall

21 ½ cm x 13 ½ cm photograph of Samuel DeVeaux Woodruff taken in October of 1891 at DeVeaux Hall in St. Catharines. Mr. Woodruff is carrying a rifle and has caught 6 woodcock and 2 quail. The photograph was described by R. Band of Toronto in 1977 and is included.

Photograph - Woodruff Children, Wisteria Arbour at DeVeaux Hall

Black and white, 9 ½ cm x 12 cm photograph, mounted on board, of Margaret Julia Woodruff, William Alfred Woodruff, Gladys Caroline Woodruff and Samuel DeVeaux Woodruff II in front of the Wisteria arbour at DeVeaux Hall in St. Catharines in front of the grapery house.

Photograph - Thomas Woodruff and Julia Cleveland Woodruff at DeVeaux Hall

Black and white, 12 cm x 17 cm photograph, mounted on board, of DeVeaux Hall in St. Catharines, Ontario. It was built by Samuel DeVeaux Woodruff. Shown in this photo are Thomas Woodruff and Julia Cleveland Woodruff. This photo was described by R.W. Band in 1973 and is included.

Photograph - DeVeaux Hall

Black and white, 12 cm x 17 cm photograph, mounted on board, of DeVeaux Hall in St. Catharines. Thomas Woodruff is shown in this photo. The photo was described by R.W. Band in 1973 and is included.

Postcard - W.D. Woodruff Homestead, DeVeaux Hall, St. Catharines, Ontario

A black and white postcard of the W.D. Woodruff homestead, DeVeaux Hall, St. Catharines, Ontario. See reverse for note.

Masonic photo album collection, Eureka Lodge #20, Prince Hall, Toronto, ca. 1970s-1980s

The collection consists of two photo albums from Eureka Lodge #20, Prince Hall, Toronto, Ontario. The first album consists of 57 colour photographs of Black Shriners and Masons, some featuring a trip to Puerto Rico, circa 1970. Several loose items are enclosed, including photographs, news clippings, and a certificate. The second album contains 26 colour photographs, and 9 loose photographs, circa 1980. Includes photographs of Arthur Downes, one of Canada’s first Black Canadian Grand Masters and Joe Halstead (Order of Canada). Most of the photographs feature members in the lodge interior.

Payment for the Hall account

Payment for the Hall account, May 28, 1883.