Receipt from E.C. Staples, proprietor of Old Orchard House, Old Orchard Beach,

Receipt from E.C. Staples, proprietor of Old Orchard House, Old Orchard Beach, Maine for bath house and laundry, Aug. 15, 1887.

The effects of R(+)-lipoic acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase

This thesis investigated whole body glucose disposal and the adaptive changes in skeletal muscle carbohydrate metabolism following 28 d of supplementation with 1000 mg R(+)-lipoic acid in young sedentary males (age, 22.1 ± 0.67 yr, body mass, 78.7 ± 10.3 kg, n=9). In certain individuals, lipoic acid decreased the 180-min area under the glucose concentration and insulin concentration curve during an oral glucose tolerance test (OGTT) (n=4). In the same individuals, lipoic acid supplementation decreased pyruvate dehydrogenase kinase activity (PDK) (0.09 ± 0.024 min"^ vs. 0.137 ± 0.023 min'\ n=4). The fasting levels of the activated form of pyruvate dehydrogenase (PDHa) were decreased following lipoic acid (0.42 ± 0.13 mmol-min'kg'^ vs. 0.82 ± 0.32 mmolrnin'^kg"\ n=4), yet increased to a greater extent during the OGTT (1.21 ± 0.34 mmol-min'kg"' vs. 0.81 ±0.13 mmolmin"'kg'\ n=4) following hpoic acid supplementation. No changes were demonstrated in the remaining subjects (n=5). It was concluded that improved glucose clearance during an OGTT following lipoic acid supplementation is assisted by increased muscle glucose oxidation through increased PDHa activation and decreased PDK activity in certain individuals.

Niagara Parks Commission annual report, March 1885.

Printed by Order of the Legislative Assembly of Ontario.

Brief memories of Niagara : its rapids, falls, and whirlpool /

On cover and spine: Memories of Niagara.

Niagara Parks Commission annual report, September 1885.

Printed by Order of the Legislative Assembly of Ontario.

Niagara Parks Commission annual report, 1886.

Printed by Order of the Legislative Assembly of Ontario.

Niagara Parks Commission annual report, 1895.

Printed by Order of the Legislative Assembly of Ontario.

Niagara Parks Commission annual report, 1896.

Printed by Order of the Legislative Assembly of Ontario.

Niagara Parks Commission annual report, 1897.

Printed by Order of the Legislative Assembly of Ontario.

Niagara Parks Commission annual report, 1898.

Printed by Order of the Legislative Assembly of Ontario.

Niagara Parks Commission annual report, 1899.

Printed by Order of the Legislative Assembly of Ontario.

Niagara Parks Commission annual report, 1900.

Printed by Order of the Legislative Assembly of Ontario.

Niagara Parks Commission annual report, 1901.

Printed by Order of the Legislative Assembly of Ontario.

Niagara Parks Commission annual report, 1902.

Printed by Order of the Legislative Assembly of Ontario.

Niagara Parks Commission annual report, 1903.

Printed by Order of the Legislative Assembly of Ontario.