5 resultados para menstrual irregularity
em Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland
Resumo:
The trend of concentrating to core competencies leads to outsourcing of non-core activities. One such activity is logistics, where the responsibility is given to third-party service providers. This means the service provider acts as an intermediary between the buyer and the end customer. This thesis concentrates on depicting the operational environment of one such service provider, Swissport Finland Ltd, and the improvement of their checked baggage irregularity service. The tools used for this work were service blueprinting, an illustrative method for service mapping, and failure modes and effects analysis. The theoretical part of the thesis offers a framework for using these tools for logistics services, while the empirical part consists of a study mostly qualitative in nature. Action research method was used for the service improvement research. According to the results of this study the combination of service blueprinting and FMEA can be used successfully for irregularity service improvement. The most important result was an enhanced irregularity process that has been found to alleviate earlier problems.
Resumo:
Adolescence is an important time for acquiring high peak bone mass. Physical activity is known to be beneficial to bone development. The effect of estrogen-progestin contraceptives (EPC) is still controversial. Altogether 142 (52 gymnasts, 46 runners, and 42 controls) adolescent women participated in this study, which is based on two 7-year (n =142), one 6-year (n =140) and one 4-year (n =122) follow-ups. Information on physical activity, menstrual history, sexual maturation, nutrition, living habits and health status was obtained through questionnaires and interviews. The bone mineral density (BMD) and content (BMC) of lumbar spine (LS) and femoral neck (FN) were measured by dual- energy X-ray absoptiometry. Calcaneal sonographic measurements were also made. The physical activity of the athletes participating in this study decreased after 3-year follow-up. High-impact exercise was beneficial to bones. LS and FN BMC was higher in gymnasts than in controls during the follow-up. Reduction in physical activity had negative effects on bone mass. LS and FN BMC increased less in the group having reduced their physical activity more than 50%, compared with those continuing at the previous level (1.69 g, p=0.021; 0.14 g, p=0.015, respectively). The amount of physical activity was the only significant parameter accounting for the calcaneal sonography measurements at 6-year follow-up (11.3%) and reduced activity level was associated with lower sonographic values. Long-term low-dose EPC use seemed to prevent normal bone mass acquisition. There was a significant trend towards a smaller increase in LS and FN BMC among long-term EPC users. In conclusion, this study confirms that high-impact exercise is beneficial to bones and that the benefits are partly maintained even after a clear reduction in training level at least for 4 years. Continued exercise is needed to retain all acquired benefits. The bone mass gained and maintained can possibly be maximized in adolescence by implementing high-impact exercise for youngsters. The peak bone mass of the young women participating in the study may be reached before the age of 20. Use of low-dose EPCs seems to suppress normal bone mass acquisition.
Resumo:
Endometriosis is a common hormone-dependent gynecological disease leading to severe menstrual and/or chronic pelvic pain with or without subfertility. The disease is defined by the presence of endometrium-like tissue outside the uterine cavity, primarily on the pelvic peritoneum, ovaries and infiltrating organs of the peritoneal cavity. The current tools for diagnosis and treatment of endometriosis need to be improved to ensure reliable diagnosis and effective treatment. In addition, endometriosis is associated with increased risk of ovarian cancer and, therefore, the differential diagnosis between the benign and malignant ovarian cysts is of importance. The long-term objective of the present study was to support the discovery of novel tools for diagnosis and treatment of endometriosis. This was approached by exploiting genome-wide expression analysis of endometriosis specimens. A novel expression profiling -based classification of endometriosis indicated specific subgroups of lesions partially consistent with the clinical appearance, but partially according to unknown factors. The peritoneum of women with endometriosis appeared to be altered in comparison to that of healthy control subjects, suggesting a novel aspect on the pathogenesis of the disease. The evaluation of action and metabolism of sex hormones in endometrium and endometriosis tissue indicated a novel role of androgens in regulation of the tissues. In addition, an enzyme involved in androgen and neurosteroid metabolism, hydroxysteroid (17beta) dehydrogenase 6, was found to be highly up-regulated in endometriosis tissue as compared to healthy endometrium. The enzyme may have a role in the pathogenesis of endometriosis or in the endometriosis associated pain generation. Finally, a new diagnostic biomarker, HE4, was discovered distinguishing patients with ovarian endometriotic cysts from those with malignant ovarian cancer. The information acquired in this study enables deeper understanding of endometriosis and facilitates the development of improved diagnostic tools and more specific treatments of the disease
Resumo:
Isännöintiala on tämän päivän Suomessa yhä suurempien haasteiden edessä asiakkaiden ja yhteiskunnan asettamien vaatimusten kasvaessa mutta samalla käytössä olevien resurssien niukentuessa. Tämä työ toimii osana kokonaisvaltaisempaa asiantuntijapalveluprosessien kehittämiseen keskittyvää projektia, jonka keskipisteessä ovat isännöintipalvelut ja niiden kehittäminen kohdeyrityksen tarpeiden mukaisesti. Diplomityössä keskitytään isännöintipalveluiden kehittämiseen palveluiden paketoimisen ja hinnoittelun sekä asiakassegmentoinnin näkökulmasta. Työn tavoitteena oli löytää uusia ratkaisumalleja vastaamaan kohdeyrityksen tulevaisuuden tavoitteisiin samalla huomioiden toimintaympäristön muuttuvat tarpeet. Projekti jakautui kahteen osaan; nykytila-analyysiin ja sen pohjalta rakennettaviin ratkaisuehdotuksiin. Nykytila-analyysin avulla haluttiin löytää nykyisen toiminnan keskeisimmät ongelmakohdat, joihin haettiin sittemmin ratkaisua palveluiden uudelleenpaketoimisen myötä. Merkittävimpiä havaittuja ongelmatekijöitä olivat työn kuormittavuuden epätasainen jakautuminen ja se, ettei kuormittavuutta huomioitu tavassa tuottaa tai hinnoitella palveluita. Kuormittavuuden epätasainen jakautuminen otettiin lähtökohdaksi asiakassegmentoinnin ja palveluiden uudelleenpaketoinnin toteuttamisessa.