Measuring mobile WAP protocol based services

WAP tulee olemaan tulevaisuudessa tärkeässä roolissa, kun etsitään sopivaa tiedonsiirtoprotokollaa uusille mobiilipalveluille. Vaikka WAP jollain tavalla epäonnistui ensimmäisessä tulemisessaan sen suosio varmasti tulevaisuudessa tulee kasvamaan. WAP:in heikko suosio ei johtunut niinkään protokollan tiedonsiirto ominaisuuksista, vaan WAP-palveluiden kehittymättömyydestä. Tulevaisuuden palvelut kuitenkin ovat kehittyneempiä ja WAP:in suosio tulee kasvamaan. Viimeisimpänä WAP:ia käyttävänä palveluna on esitelty MMS. Kun uudet WAP:iin pohjautuvat palvelut yleistyvät, asettaa se uusia vaatimuksia myös WAP gateway:lle. Työssä tarkastellaan erilaisia mahdollisuuksia mitata mobiilisti WAP palvelujen palvelun tasoa. Työssä myös toteutetaan mobiili WAP palveluiden mittauskomponentti, joka toimii osana laajempaa ohjelmistoa. Tarkoituksena on toteuttaa mittauskomponentti, joka emuloi mahdollisimman hyvin todellista loppukäyttäjää.

Probiotic interventions in infancy: Benefit and Safety Assessment of Extended Applications

Immaturity of the gut barrier system in the newborn has been seen to underlie a number of chronic diseases originating in infancy and manifesting later in life. The gut microbiota and breast milk provide the most important maturing signals for the gut-related immune system and reinforcement of the gut mucosal barrier function. Recently, the composition of the gut microbiota has been proposed to be instrumental in control of host body weight and metabolism as well as the inflammatory state characterizing overweight and obesity. On this basis, inflammatory Western lifestyle diseases, including overweight development, may represent a potential target for probiotic interventions beyond the well documented clinical applications. The purpose of the present undertaking was to study the efficacy and safety of perinatal probiotic intervention. The material comprised two ongoing, prospective, double-blind NAMI (Nutrition, Allergy, Mucosal immunology and Intestinal microbiota) probiotic interventions. In the mother-infant nutrition and probiotic study altogether 256 women were randomized at their first trimester of pregnancy into a dietary intervention and a control group. The intervention group received intensive dietary counselling provided by a nutritionist, and were further randomized at baseline, double-blind, to receive probiotics (Lactobacillus rhamnosus GG and Bifidobacterium lactis) or placebo. The intervention period extended from the first trimester of pregnancy to the end of exclusive breastfeeding. In the allergy prevention study altogether 159 women were randomized, double-blind, to receive probiotics (Lactobacillus rhamnosus GG) or placebo 4 weeks before expected delivery, the intervention extending for 6 months postnatally. Additionally, patient data on all premature infants with very low birth weight (VLBW) treated in the Department of Paediatrics, Turku University Hospital, during the years 1997 - 2008 were utilized. The perinatal probiotic intervention reduced the risk of gestational diabetes mellitus (GDM) in the mothers and perinatal dietary counselling reduced that of fetal overgrowth in GDM-affected pregnancies. Early gut microbiota modulation with probiotics modified the growth pattern of the child by restraining excessive weight gain during the first years of life. The colostrum adiponectin concentration was demonstrated to be dependent on maternal diet and nutritional status during pregnancy. It was also higher in the colostrum received by normal-weight compared to overweight children at the age of 10 years. The early perinatal probiotic intervention and the postnatal probiotic intervention in VLBW infants were shown to be safe. To conclude, the findings in this study provided clinical evidence supporting the involvement of the initial microbial and nutritional environment in metabolic programming of the child. The manipulation of early gut microbial communities with probiotics might offer an applicable strategy to impact individual energy homeostasis and thus to prevent excessive body-weight gain. The results add weight to the hypothesis that interventions aiming to prevent obesity and its metabolic consequences later in life should be initiated as early as during the perinatal period.

SDN in an ISP Environment

As computer networks grow larger and more complex there is a need for a new, simpler kind of approach to configuring them. Software Defined Networking (SDN) takes the control plane away from individual nodes and centralizes the network control by utilizing a flow based traffic management. In this thesis the suitability of SDN in a small ISP (Internet Service Provider) network is considered for an alternative to the current traditional core network and access network OSSs (Operations Support System), mainly to simplify the network management but also to see what else would SDN offer for such an environment. Combining information learned from a theoretical study on the matter to a more practical experiment of SDN network simulation using Mininet simulation software and OpenDayLight SDN controller software does this. Although the simulation shows that SDN is able to provide the functionality needed for the network, the immaturity of the technology suggests that for a small ISP network there is no need to utilize SDN just yet. For when SDN becomes more commonplace a brief transition plan is introduced.

Central auditory processing and the acquisition of phonology in 2-year-old children with recurrent acute otitis media

Middle ear infections (acute otitis media, AOM) are among the most common infectious diseases in childhood, their incidence being greatest at the age of 6–12 months. Approximately 10–30% of children undergo repetitive periods of AOM, referred to as recurrent acute otitis media (RAOM). Middle ear fluid during an AOM episode causes, on average, 20–30 dB of hearing loss lasting from a few days to as much as a couple of months. It is well known that even a mild permanent hearing loss has an effect on language development but so far there is no consensus regarding the consequences of RAOM on childhood language acquisition. The results of studies on middle ear infections and language development have been partly discrepant and the exact effects of RAOM on the developing central auditory nervous system are as yet unknown. This thesis aims to examine central auditory processing and speech production among 2-year-old children with RAOM. Event-related potentials (ERPs) extracted from electroencephalography can be used to objectively investigate the functioning of the central auditory nervous system. For the first time this thesis has utilized auditory ERPs to study sound encoding and preattentive auditory discrimination of speech stimuli, and neural mechanisms of involuntary auditory attention in children with RAOM. Furthermore, the level of phonological development was studied by investigating the number and the quality of consonants produced by these children. Acquisition of consonant phonemes, which are harder to hear than vowels, is a good indicator of the ability to form accurate memory representations of ambient language and has not been studied previously in Finnish-speaking children with RAOM. The results showed that the cortical sound encoding was intact but the preattentive auditory discrimination of multiple speech sound features was atypical in those children with RAOM. Furthermore, their neural mechanisms of auditory attention differed from those of their peers, thus indicating that children with RAOM are atypically sensitive to novel but meaningless sounds. The children with RAOM also produced fewer consonants than their controls. Noticeably, they had a delay in the acquisition of word-medial consonants and the Finnish phoneme /s/, which is acoustically challenging to perceive compared to the other Finnish phonemes. The findings indicate the immaturity of central auditory processing in the children with RAOM, and this might also emerge in speech production. This thesis also showed that the effects of RAOM on central auditory processing are long-lasting because the children had healthy ears at the time of the study. An effective neural network for speech sound processing is a basic requisite of language acquisition, and RAOM in early childhood should be considered as a risk factor for language development.