Allocation of added selenium in lettuce and its impact on roots

Selostus: Seleenin jakautuminen salaatin versoihin ja vaikutus juuriin

The fear of openness : an essay on friendship and the roots of morality

Det förefaller självklart att begrepp som lojalitet, respekt, rättigheter eller altruism beskriver något entydigt gott. Men tänk om det i själva verket är så att de aktualiseras bara där vi avvisat godheten? Tänk om vår moral och hela vårt liv genomsyras av en djup förvirring, av en ovilja att se vad som egentligen pågår mellan oss? I min avhandling ställer jag de här obekväma frågorna. Utgångspunkten är en diskussion om vänskap, som jag beskriver som en förbehållslös, helhjärtad öppenhet mellan människor. Denna öppenhet – som lika väl kan kallas godhet eller kärlek – är det svåraste som finns. Samtidigt finns öppenheten alltid där mellan oss, om så bara som en anad möjlighet som skrämmer oss, som vi sluter oss för och inte vill veta av. Vi lever i en ständig spänning mellan öppenhet och avvisande, och denna spänning yttrar sig i allt vi gör, känner och tänker. Det är vad jag vill visa. Bland de filosofer jag diskuterar kan nämnas Aristoteles, Kant, Kierkegaard, Nietzsche och Emmanuel Levinas.

The Roots of Neurofibromas in Neurofibromatosis 1 — A Question of Multipotency, Differentiation and Hiding

Neurofibromatosis type 1 (NF1) is an autosomal dominant cancer predisposition syndrome that affects about 1 in 3500 individuals worldwide. NF1 is caused by mutations in the NF1 gene that encodes the tumor suppressor protein neurofibromin, an inactivator of the Ras oncogene. The hallmarks of NF1 include pigmentary lesions of the skin, Lisch nodules of the iris and cutaneous neurofibromas. Cutaneous neurofibromas are benign tumors composed of all the cell types of normal peripheral nerve. The traditional view of neurofibroma development has been that cutaneous neurofibromas arise from the disruption of the small nerve tributaries of the skin and subsequent proliferation of the resident cells. The second hit mutation in the NF1 gene has been considered as a prerequisite for neurofibroma development. The second hit is detectable in a subpopulation of primary Schwann cells cultured from neurofibromas. This thesis challenges the traditional concept of neurofibroma development. The results show that cutaneous neurofibromas are intimately associated with hair follicular structures and contain multipotent precursor cells (NFPs), suggesting that neurofibromas may arise from the multipotent cells which reside in hair follicles. Furthermore, this study presents that neurofibroma-derived Schwann cells that harbor bi-allelic inactivation in the NF1 gene express HLA class II genes and may act as nonprofessional antigen presenting cells. The CD4- and FoxP3-positive cells detected in cutaneous neurofibromas suggest that these cells may represent regulatory T cells (Tregs) which interact with HLA II –positive cells and aid the tumor cells in hiding from the immune system and are thus mediators of immune tolerance. This thesis also investigated neurofibroma development in the oral cavity and the use of different biomarkers to characterize cellular differentiation in neurofibromas. The results revealed that oral neurofibromas are not rare, but they usually appear as solitary lesions contrary to multiple cutaneous neurofibromas and present high heterogeneity within and between tumors. The use of class III beta-tubulin as a marker for neuronal differentiation led to an unexpected finding showing that multiple cell types express class III beta-tubulin during mitosis. The increased understanding of the multipotency of tumor cells, cellular differentiation and ability to hide from immune system will aid in the development of future treatments. Specifically, targeting Tregs in NF1 patients could provide a novel therapeutic approach to interfere with the development of neurofibromas.

Incest aversion : the evolutionary roots of individual regulation

Den evolutionära förklaringen till den allmänt utbredda incestaversionen, dvs. motviljan för sex med nära släktingar, försöker besvara såväl frågan om varför incestaversionen gynnats i det naturliga urvalet som frågan om hur denna aversion regleras på individuell nivå. Eftersom inavlade barn har en försämrad biologisk duglighet än andra barn, medför kostnaderna av denna icke-optimala reproduktion ett selektionstryck mot inavel. I en serie studier visade vi att eftersom kvinnor i allmänhet satsar mer biologiska resurser på sina barn än vad män gör, känner kvinnor starkare incestaversion än män och eftersom det endast är fertila kvinnor som riskerar satsa resurser i en inavlad avkomma har även fertila kvinnor högre incestaversion än icke-fertila kvinnor. Vi visade också att de biologiska kostnaderna av inavel inte begränsas till enbart de individer som har incest. Eftersom alla våra biologiska släktingar sannolikt delar våra alleler speglar incestaversionen även de biologiska kostnader som incest mellan våra släktingar medför åt oss. Den psykologiska mekanism med vilken incestsituationer bedöms har hittills varit okänd. I våra studier testades teorin om självreflekterande empati. Enligt den teorin bedöms sådana situationer emotionellt genom att man själv föreställer sig ha sex med motsvarande släkting och känslan som väcks i denna process ger därefter emotionell information till bedömningen av andras incest. I tre delstudier fann vi att självreflektion var positivt associerat med styrkan av aversion gentemot andras incest, vilket stöder teorin om självreflekterande empati.

Luovuus näyttelijäntyössä

This thesis considers creativity in acting and performing. The original question is how to construct roles creatively. The thesis also considers the quality of creativity at a general level. In addition, the question expands to consider directing and, briefly, the ethics of making theatre. The first section discusses acceptation as a tool for opening the blocks that restrain creativity. It also discusses what the use of acceptation causes and what challenges it brings when creativity begins. The second and the third sections deal with two productions that have changed the author's view of creativity and theatre. The first production is "Medeia Goes Karaoke". This section considers the influence of listening and being in contact when making the role of Medeia. The second production is about directing, "My Roots are Water and Blood". This section considers revising performing and directing and especially the influence of the Alexander-technique. The last section concerns the definition of what good acting is. It also discusses the differences between performing and acting and presents the author's opinions concerning the ethics of acting. The aim of this work is to define creativity in acting, performing and theatre-making, through the author' s personal experiences.

Naiskomiikka : huumorista stand upiin, naurusta valtaan

The final project deals with the question of female comedy and the comedy made by women. Comedy has traditionally been made by men and the woman has been the one who laughs. A funny woman has been a rare phenomenon. Although times have changed and gender roles have become more flexible, female comedians still remain in a minority compared to their male colleagues. The essay reviews the social and historical structures that influence the position of women in general and on the field of comedy in particular. The teoretical basis to this is feminist theory. Female comedy and humour have features of their own, that are being examined in the essay. It also makes a difference between feminine comedy and feminist comedy. Largely the project handles stand up comedy. The popularity of stand up comedy has changed the field of professional entertainment and brought a number of widely gifted comedians to a common knowledge. Stand up has an opportunity to be a political tool, which is essential for marginal comedians, which also includes female comedians. One of the fundamental subjects of the project is the political character of comedy. The essay also portrays the historical roots of stand up comedy in the Finnish and in the American tradition. It reflects on the fore mothers of the modern female comedian. The reasons that make a woman become a comedian are under consideration, as well as the strategies that help her to get her voice and message delivered. Since a woman is still held in the marginal, it gives female comedy a feature of its own. This way comedy can become a tool for a feminist battle.

Kaksoiselämäni teatteritaiteen palveluksessa : ammatti-identiteettini rakennuselementit

In my thesis I discuss the elements of my professional identity from the perspective of an actor, a director and a team. What are acting and directing to me? What are the problems in the symbiosis of acting and directing? What are the difficulties in acting and directing and how important are the issues related to responsibility, power, trust and confidence in my work? I also discuss the consept of self-confidence. Behind all of this, there is also the thought of my ancestry and its dualism, how my roots from my father's and mother's side are struggling against each other or supporting each other, and how they affect my professional identity. The basic idea in the present thesis is the perspective of the traditional theatre and a professional team. Also the childhood influence on my professional identity is being considered. Education is discussed at the end. Moreover, a discussion on the kind of future theatre maker I want to be considered as, is included. I also try to handle all these topics through Harri Virtanen's Kiinteistövälittäjä vastoin tahtoaan (2005), which I directed, and my latest role in Arto Paasilinna's and Kristian Smeds' Jäniksen vuosi (2006). The conclusion of the present thesis is that it is very important for me to be a member of different communities, in which I can express my professional identity. My professional identity is formed by many elements that support each other. Such elements in their own right form an inticate relationship, which at the end, makes me what I am. In conclusion, I am a theatre maker, who in an alternative field of theater has opportunities to form the professional identity, as different situations and projects require.

Reflections on pre-Uralic and the "Saami-Finnic protolanguage"

Vastine Pekka Sammallahden artikkeliin Language and roots Congressus internationalis Fenno-Ugristarum (1995): Congressus octavus internationalis Fenno-Ugristarum, Jyväskylä 10.-15.8.1995. - Jyväskylä : Moderatores. ISBN 952-90-6684-8. Pars 1 : Orationes plenariae et conspectus quinquennales, s. 143-153